YES1 Kinase Mediates the Membrane Removal of Rescued F508del-CFTR in Airway Cells by Promoting MAPK Pathway Activation via SHC1

Recent developments in CFTR modulator drugs have had a significant transformational effect on the treatment of individuals with Cystic Fibrosis (CF) who carry the most frequent F508del-CFTR mutation in at least one allele. However, the clinical effects of these revolutionary drugs remain limited by...

Descripción completa

Detalles Bibliográficos
Autores principales: Barros, Patrícia, Matos, Ana M., Matos, Paulo, Jordan, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296715/
https://www.ncbi.nlm.nih.gov/pubmed/37371529
http://dx.doi.org/10.3390/biom13060949

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296715/
https://www.ncbi.nlm.nih.gov/pubmed/37371529
http://dx.doi.org/10.3390/biom13060949

Ejemplares similares