Cargando…

YES1 Kinase Mediates the Membrane Removal of Rescued F508del-CFTR in Airway Cells by Promoting MAPK Pathway Activation via SHC1

Recent developments in CFTR modulator drugs have had a significant transformational effect on the treatment of individuals with Cystic Fibrosis (CF) who carry the most frequent F508del-CFTR mutation in at least one allele. However, the clinical effects of these revolutionary drugs remain limited by...

Descripción completa

Detalles Bibliográficos
Autores principales:	Barros, Patrícia, Matos, Ana M., Matos, Paulo, Jordan, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296715/ https://www.ncbi.nlm.nih.gov/pubmed/37371529 http://dx.doi.org/10.3390/biom13060949

Ejemplares similares

Treatment of Polarized Cystic Fibrosis Airway Cells With HGF Prevents VX-661-Rescued F508del-CFTR Destabilization Caused by Prolonged Co-exposure to VX-770
por: Matos, Ana M., et al.
Publicado: (2021)

Prolonged co-treatment with HGF sustains epithelial integrity and improves pharmacological rescue of Phe508del-CFTR
por: Matos, Ana M., et al.
Publicado: (2018)

Extracellular phosphate enhances the function of F508del-CFTR rescued by CFTR correctors
por: Saint-Criq, Vinciane, et al.
Publicado: (2021)

Full Rescue of F508del-CFTR Processing and Function by CFTR Modulators Can Be Achieved by Removal of Two Regulatory Regions
por: Uliyakina, Inna, et al.
Publicado: (2020)

The CFTR Amplifier Nesolicaftor Rescues TGF-β1 Inhibition of Modulator-Corrected F508del CFTR Function
por: Bengtson, Charles, et al.
Publicado: (2022)

Functional Rescue of F508del-CFTR Using Small Molecule Correctors
por: Molinski, Steven, et al.
Publicado: (2012)

ΔF508 CFTR interactome remodeling promotes rescue of Cystic Fibrosis
por: Pankow, Sandra, et al.
Publicado: (2015)

c-Cbl reduces stability of rescued ∆F508-CFTR in human airway epithelial cells: Implications for cystic fibrosis treatment
por: Cihil, Kristine M., et al.
Publicado: (2013)

Partial Rescue of F508del-CFTR Stability and Trafficking Defects by Double Corrector Treatment
por: Capurro, Valeria, et al.
Publicado: (2021)

Elexacaftor Mediates the Rescue of F508del CFTR Functional Expression Interacting with MSD2
por: Bongiorno, Roberta, et al.
Publicado: (2023)

Molecular Structures Reveal Synergistic Rescue of Δ508 CFTR by Trikafta Modulators
por: Fiedorczuk, Karol, et al.
Publicado: (2022)

Production of CFTR-ΔF508 Rabbits
por: Yang, Dongshan, et al.
Publicado: (2021)

Analysis of multiple gene co-expression networks to discover interactions favoring CFTR biogenesis and ΔF508-CFTR rescue
por: Strub, Matthew D., et al.
Publicado: (2021)

Is CFTR-delF508 Really Absent from the Apical Membrane of the Airway Epithelium?
por: Borthwick, Lee A., et al.
Publicado: (2011)

Tgf-β1 Inhibits Cftr Biogenesis and Prevents Functional Rescue of ΔF508-Cftr in Primary Differentiated Human Bronchial Epithelial Cells
por: Snodgrass, Steven M., et al.
Publicado: (2013)

Ouabain Mimics Low Temperature Rescue of F508del-CFTR in Cystic Fibrosis Epithelial Cells
por: Zhang, Donglei, et al.
Publicado: (2012)

The Primary Folding Defect and Rescue of ΔF508 CFTR Emerge during Translation of the Mutant Domain
por: Hoelen, Hanneke, et al.
Publicado: (2010)

Calpain Inhibition Promotes the Rescue of F(508)del-CFTR in PBMC from Cystic Fibrosis Patients
por: Averna, Monica, et al.
Publicado: (2013)

Rescue of Murine F508del CFTR Activity in Native Intestine by Low Temperature and Proteasome Inhibitors
por: Wilke, Martina, et al.
Publicado: (2012)

Phosphorylation of the Chaperone-Like HspB5 Rescues Trafficking and Function of F508del-CFTR
por: Degrugillier, Fanny, et al.
Publicado: (2020)

SFPQ rescues F508del-CFTR expression and function in cystic fibrosis bronchial epithelial cells
por: Kumar, Parameet, et al.
Publicado: (2021)

KDM2A and KDM3B as Potential Targets for the Rescue of F508del-CFTR
por: D’Amore, Claudio, et al.
Publicado: (2022)

Abnormal spatial diffusion of Ca(2+ )in F508del-CFTR airway epithelial cells
por: Antigny, Fabrice, et al.
Publicado: (2008)

Recovery of ΔF508-CFTR Function by Citrate
por: Borkenhagen, Beatrice, et al.
Publicado: (2022)

Defective Fluid Secretion from Submucosal Glands of Nasal Turbinates from CFTR(-/-) and CFTR(ΔF508/ΔF508) Pigs
por: Cho, Hyung-Ju, et al.
Publicado: (2011)

Targeting DNAJB9, a novel ER luminal co-chaperone, to rescue ΔF508-CFTR
por: Huang, Yunjie, et al.
Publicado: (2019)

Molecular Docking and QSAR Studies as Computational Tools Exploring the Rescue Ability of F508del CFTR Correctors
por: Righetti, Giada, et al.
Publicado: (2020)

Integrative chemogenomic analysis identifies small molecules that partially rescue ΔF508‐CFTR for cystic fibrosis
por: Hodos, Rachel A., et al.
Publicado: (2021)

Characterization of Nasal Potential Difference in cftr Knockout and F508del-CFTR Mice
por: Saussereau, Emilie Lyne, et al.
Publicado: (2013)

Short-term consequences of F508del-CFTR thermal instability on CFTR-dependent transepithelial currents in human airway epithelial cells
por: Froux, Lionel, et al.
Publicado: (2019)

Stabilizing Rescued Surface-Localized ΔF508 CFTR by Potentiation of Its Interaction with Na(+)/H(+) Exchanger Regulatory Factor 1
por: Arora, Kavisha, et al.
Publicado: (2014)

Correction of F508del CFTR in airway epithelium using nanoparticles delivering triplex-forming PNAs
por: McNeer, Nicole Ali, et al.
Publicado: (2015)

Benzbromarone Stabilizes ΔF508 CFTR at the Cell Surface
por: Loo, Tip W., et al.
Publicado: (2011)

In vivo model for modulators of CFTR(ΔF508) misfolding
Publicado: (2012)

Correctors modify the bicarbonate permeability of F508del-CFTR
por: Fiore, Michele, et al.
Publicado: (2020)

Integrative genomic meta-analysis reveals novel molecular insights into cystic fibrosis and ΔF508-CFTR rescue
por: Hodos, Rachel A., et al.
Publicado: (2020)

Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation
por: Stefano, Daniela De, et al.
Publicado: (2014)

High-Content Surface and Total Expression siRNA Kinase Library Screen with VX-809 Treatment Reveals Kinase Targets that Enhance F508del-CFTR Rescue
por: Perkins, Lydia A., et al.
Publicado: (2018)

Understanding protein kinase CK2 mis-regulation upon F508del CFTR expression
por: Venerando, Andrea, et al.
Publicado: (2011)

CFTR-F508 pigs provide new clues to cystic fibrosis
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_agfnnv94dpg0aefaj5ekpq7vk2