Unconventional Source of Neurotoxic Protein Aggregation from Organelle Off-Target Bax∆2 in Alzheimer’s Disease

Protein aggregates are a hallmark of Alzheimer’s disease (AD). Extensive studies have focused on β-amyloid plaques and Tau tangles. Here, we illustrate a novel source of protein aggregates in AD neurons from organelle off-target proteins. Bax is a mitochondrial pore-forming pro-death protein. What h...

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Detalles Bibliográficos
Autores principales: Yao, Qi, Mascarenhas dos Santos, Anne Caroline, Zhang, Huaiyuan, Mañas, Adriana, Hussaini, Ammarah, Kim, Ujin, Xu, Congtai, Basheer, Sana, Tasaki, Shinya, Xiang, Jialing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296721/
https://www.ncbi.nlm.nih.gov/pubmed/37371550
http://dx.doi.org/10.3390/biom13060970

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296721/
https://www.ncbi.nlm.nih.gov/pubmed/37371550
http://dx.doi.org/10.3390/biom13060970

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