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Recent Progress in Diboronic-Acid-Based Glucose Sensors
Non-enzymatic sensors with the capability of long-term stability and low cost are promising in glucose monitoring applications. Boronic acid (BA) derivatives offer a reversible and covalent binding mechanism for glucose recognition, which enables continuous glucose monitoring and responsive insulin...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296726/ https://www.ncbi.nlm.nih.gov/pubmed/37366983 http://dx.doi.org/10.3390/bios13060618 |
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author | Nan, Ke Jiang, Yu-Na Li, Meng Wang, Bing |
author_facet | Nan, Ke Jiang, Yu-Na Li, Meng Wang, Bing |
author_sort | Nan, Ke |
collection | PubMed |
description | Non-enzymatic sensors with the capability of long-term stability and low cost are promising in glucose monitoring applications. Boronic acid (BA) derivatives offer a reversible and covalent binding mechanism for glucose recognition, which enables continuous glucose monitoring and responsive insulin release. To improve selectivity to glucose, a diboronic acid (DBA) structure design has been explored and has become a hot research topic for real-time glucose sensing in recent decades. This paper reviews the glucose recognition mechanism of boronic acids and discusses different glucose sensing strategies based on DBA-derivatives-based sensors reported in the past 10 years. The tunable pK(a), electron-withdrawing properties, and modifiable group of phenylboronic acids were explored to develop various sensing strategies, including optical, electrochemical, and other methods. However, compared to the numerous monoboronic acid molecules and methods developed for glucose monitoring, the diversity of DBA molecules and applied sensing strategies remains limited. The challenges and opportunities are also highlighted for the future of glucose sensing strategies, which need to consider practicability, advanced medical equipment fitment, patient compliance, as well as better selectivity and tolerance to interferences. |
format | Online Article Text |
id | pubmed-10296726 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102967262023-06-28 Recent Progress in Diboronic-Acid-Based Glucose Sensors Nan, Ke Jiang, Yu-Na Li, Meng Wang, Bing Biosensors (Basel) Review Non-enzymatic sensors with the capability of long-term stability and low cost are promising in glucose monitoring applications. Boronic acid (BA) derivatives offer a reversible and covalent binding mechanism for glucose recognition, which enables continuous glucose monitoring and responsive insulin release. To improve selectivity to glucose, a diboronic acid (DBA) structure design has been explored and has become a hot research topic for real-time glucose sensing in recent decades. This paper reviews the glucose recognition mechanism of boronic acids and discusses different glucose sensing strategies based on DBA-derivatives-based sensors reported in the past 10 years. The tunable pK(a), electron-withdrawing properties, and modifiable group of phenylboronic acids were explored to develop various sensing strategies, including optical, electrochemical, and other methods. However, compared to the numerous monoboronic acid molecules and methods developed for glucose monitoring, the diversity of DBA molecules and applied sensing strategies remains limited. The challenges and opportunities are also highlighted for the future of glucose sensing strategies, which need to consider practicability, advanced medical equipment fitment, patient compliance, as well as better selectivity and tolerance to interferences. MDPI 2023-06-04 /pmc/articles/PMC10296726/ /pubmed/37366983 http://dx.doi.org/10.3390/bios13060618 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Nan, Ke Jiang, Yu-Na Li, Meng Wang, Bing Recent Progress in Diboronic-Acid-Based Glucose Sensors |
title | Recent Progress in Diboronic-Acid-Based Glucose Sensors |
title_full | Recent Progress in Diboronic-Acid-Based Glucose Sensors |
title_fullStr | Recent Progress in Diboronic-Acid-Based Glucose Sensors |
title_full_unstemmed | Recent Progress in Diboronic-Acid-Based Glucose Sensors |
title_short | Recent Progress in Diboronic-Acid-Based Glucose Sensors |
title_sort | recent progress in diboronic-acid-based glucose sensors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296726/ https://www.ncbi.nlm.nih.gov/pubmed/37366983 http://dx.doi.org/10.3390/bios13060618 |
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