A β-Arrestin 2-Biased Dopamine Receptor Type 2 (DRD2) Agonist Is More Efficacious Than Cabergoline in Reducing Cell Proliferation in PRL-Secreting but Not in Non-Functioning Pituitary Tumor Cells

SIMPLE SUMMARY: Dopamine receptor type 2 (DRD2) mediates antitumoral effects in different types of pituitary tumors with variable efficacy. DRD2′s functionally selective agonists are able to preferentially activate the canonical G-protein-mediated signaling arm or the β-arrestin 2 pathway, which hav...

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Detalles Bibliográficos
Autores principales: Di Muro, Genesio, Mangili, Federica, Esposito, Emanuela, Barbieri, Anna Maria, Catalano, Rosa, Treppiedi, Donatella, Marra, Giusy, Nozza, Emma, Lania, Andrea G. A., Ferrante, Emanuele, Locatelli, Marco, Arosio, Maura, Peverelli, Erika, Mantovani, Giovanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296728/
https://www.ncbi.nlm.nih.gov/pubmed/37370829
http://dx.doi.org/10.3390/cancers15123218

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296728/
https://www.ncbi.nlm.nih.gov/pubmed/37370829
http://dx.doi.org/10.3390/cancers15123218

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