Cargando…

Peritumoural Strain Elastography of Newly Diagnosed Breast Tumours: Does Maximum Peritumoural Halo Depth Correlate with Tumour Differentiation and Grade?

To evaluate the diagnostic utility of the maximum ultrasound strain elastography (SE) halo depth in newly diagnosed and histologically confirmed breast lesions, a retrospective study approval was granted by the local Ethical Review Board. Overall, the maximum strain elastography peritumoural halos (...

Descripción completa

Detalles Bibliográficos
Autores principales: Gruber, Leonhard, Deeg, Johannes, Egle, Daniel, Soleiman, Afschin, Ladenhauf, Valentin, Luger, Anna, Amort, Birgit, Daniaux, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296787/
https://www.ncbi.nlm.nih.gov/pubmed/37370959
http://dx.doi.org/10.3390/diagnostics13122064
_version_ 1785063730142248960
author Gruber, Leonhard
Deeg, Johannes
Egle, Daniel
Soleiman, Afschin
Ladenhauf, Valentin
Luger, Anna
Amort, Birgit
Daniaux, Martin
author_facet Gruber, Leonhard
Deeg, Johannes
Egle, Daniel
Soleiman, Afschin
Ladenhauf, Valentin
Luger, Anna
Amort, Birgit
Daniaux, Martin
author_sort Gruber, Leonhard
collection PubMed
description To evaluate the diagnostic utility of the maximum ultrasound strain elastography (SE) halo depth in newly diagnosed and histologically confirmed breast lesions, a retrospective study approval was granted by the local Ethical Review Board. Overall, the maximum strain elastography peritumoural halos (SEPHmax)—the maximum distance between the SE stiffening area and the B-mode lesion size—in 428 cases with newly diagnosed breast lesions were retrospectively analysed alongside patient age, affected quadrant, tumour echogenicity, size, acoustic shadowing, and vascularity. Statistical analysis included an ordinary one-way ANOVA to compare the SEPHmax between BI-RADS 2, 3, and 5 groups and between tumour grades 1, 2, and 3. A binary regression analysis was used to determine the correlation between tumour malignancy and the above-mentioned demographic and imaging factors. SEPHmax was significantly higher in BI-RADS 5 tumours (5.5 ± 3.9 mm) compared to BI-RADS 3 (0.9 ± 1.7 mm, p < 0.0001) and 2 (0.6 ± 1.4 mm, p < 0.0001). The receiver operating characteristic area under the curve was 0.933 for the detection of BI-RADS 5 lesions. Furthermore, tumour grades 2 (5.6 ± 3.6 mm, p = 0.001) and 3 (6.8 ± 4.2 mm, p < 0.0001) exhibited significantly higher SEPHmax than grade 1 tumours (4.0 ± 3.9 mm). Similarly, St. Gallen Ki67-stratified low-risk (p = 0.005) and intermediate-risk (p = 0.013) tumours showed smaller SEPHmax than high-risk tumours. Multivariate analysis revealed a significant correlation between malignant differentiation and SEPHmax (standardized regression coefficient 3.17 [95% confidence interval (CI) 2.42–3.92], p < 0.0001), low tumour echogenicity (1.68 [95% CI 0.41–3.00], p = 0.03), and higher patient age (0.89 [95% CI 0.52–1.26], p < 0.0001). High SEPHmax is a strong predictor for tumour malignancy and a higher tumour grade and can be used to improve tumour characterisation before histopathological evaluation. It may also enable radiologists to identify lesions warranting observation rather than immediate biopsy.
format Online
Article
Text
id pubmed-10296787
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102967872023-06-28 Peritumoural Strain Elastography of Newly Diagnosed Breast Tumours: Does Maximum Peritumoural Halo Depth Correlate with Tumour Differentiation and Grade? Gruber, Leonhard Deeg, Johannes Egle, Daniel Soleiman, Afschin Ladenhauf, Valentin Luger, Anna Amort, Birgit Daniaux, Martin Diagnostics (Basel) Article To evaluate the diagnostic utility of the maximum ultrasound strain elastography (SE) halo depth in newly diagnosed and histologically confirmed breast lesions, a retrospective study approval was granted by the local Ethical Review Board. Overall, the maximum strain elastography peritumoural halos (SEPHmax)—the maximum distance between the SE stiffening area and the B-mode lesion size—in 428 cases with newly diagnosed breast lesions were retrospectively analysed alongside patient age, affected quadrant, tumour echogenicity, size, acoustic shadowing, and vascularity. Statistical analysis included an ordinary one-way ANOVA to compare the SEPHmax between BI-RADS 2, 3, and 5 groups and between tumour grades 1, 2, and 3. A binary regression analysis was used to determine the correlation between tumour malignancy and the above-mentioned demographic and imaging factors. SEPHmax was significantly higher in BI-RADS 5 tumours (5.5 ± 3.9 mm) compared to BI-RADS 3 (0.9 ± 1.7 mm, p < 0.0001) and 2 (0.6 ± 1.4 mm, p < 0.0001). The receiver operating characteristic area under the curve was 0.933 for the detection of BI-RADS 5 lesions. Furthermore, tumour grades 2 (5.6 ± 3.6 mm, p = 0.001) and 3 (6.8 ± 4.2 mm, p < 0.0001) exhibited significantly higher SEPHmax than grade 1 tumours (4.0 ± 3.9 mm). Similarly, St. Gallen Ki67-stratified low-risk (p = 0.005) and intermediate-risk (p = 0.013) tumours showed smaller SEPHmax than high-risk tumours. Multivariate analysis revealed a significant correlation between malignant differentiation and SEPHmax (standardized regression coefficient 3.17 [95% confidence interval (CI) 2.42–3.92], p < 0.0001), low tumour echogenicity (1.68 [95% CI 0.41–3.00], p = 0.03), and higher patient age (0.89 [95% CI 0.52–1.26], p < 0.0001). High SEPHmax is a strong predictor for tumour malignancy and a higher tumour grade and can be used to improve tumour characterisation before histopathological evaluation. It may also enable radiologists to identify lesions warranting observation rather than immediate biopsy. MDPI 2023-06-14 /pmc/articles/PMC10296787/ /pubmed/37370959 http://dx.doi.org/10.3390/diagnostics13122064 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gruber, Leonhard
Deeg, Johannes
Egle, Daniel
Soleiman, Afschin
Ladenhauf, Valentin
Luger, Anna
Amort, Birgit
Daniaux, Martin
Peritumoural Strain Elastography of Newly Diagnosed Breast Tumours: Does Maximum Peritumoural Halo Depth Correlate with Tumour Differentiation and Grade?
title Peritumoural Strain Elastography of Newly Diagnosed Breast Tumours: Does Maximum Peritumoural Halo Depth Correlate with Tumour Differentiation and Grade?
title_full Peritumoural Strain Elastography of Newly Diagnosed Breast Tumours: Does Maximum Peritumoural Halo Depth Correlate with Tumour Differentiation and Grade?
title_fullStr Peritumoural Strain Elastography of Newly Diagnosed Breast Tumours: Does Maximum Peritumoural Halo Depth Correlate with Tumour Differentiation and Grade?
title_full_unstemmed Peritumoural Strain Elastography of Newly Diagnosed Breast Tumours: Does Maximum Peritumoural Halo Depth Correlate with Tumour Differentiation and Grade?
title_short Peritumoural Strain Elastography of Newly Diagnosed Breast Tumours: Does Maximum Peritumoural Halo Depth Correlate with Tumour Differentiation and Grade?
title_sort peritumoural strain elastography of newly diagnosed breast tumours: does maximum peritumoural halo depth correlate with tumour differentiation and grade?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296787/
https://www.ncbi.nlm.nih.gov/pubmed/37370959
http://dx.doi.org/10.3390/diagnostics13122064
work_keys_str_mv AT gruberleonhard peritumouralstrainelastographyofnewlydiagnosedbreasttumoursdoesmaximumperitumouralhalodepthcorrelatewithtumourdifferentiationandgrade
AT deegjohannes peritumouralstrainelastographyofnewlydiagnosedbreasttumoursdoesmaximumperitumouralhalodepthcorrelatewithtumourdifferentiationandgrade
AT egledaniel peritumouralstrainelastographyofnewlydiagnosedbreasttumoursdoesmaximumperitumouralhalodepthcorrelatewithtumourdifferentiationandgrade
AT soleimanafschin peritumouralstrainelastographyofnewlydiagnosedbreasttumoursdoesmaximumperitumouralhalodepthcorrelatewithtumourdifferentiationandgrade
AT ladenhaufvalentin peritumouralstrainelastographyofnewlydiagnosedbreasttumoursdoesmaximumperitumouralhalodepthcorrelatewithtumourdifferentiationandgrade
AT lugeranna peritumouralstrainelastographyofnewlydiagnosedbreasttumoursdoesmaximumperitumouralhalodepthcorrelatewithtumourdifferentiationandgrade
AT amortbirgit peritumouralstrainelastographyofnewlydiagnosedbreasttumoursdoesmaximumperitumouralhalodepthcorrelatewithtumourdifferentiationandgrade
AT daniauxmartin peritumouralstrainelastographyofnewlydiagnosedbreasttumoursdoesmaximumperitumouralhalodepthcorrelatewithtumourdifferentiationandgrade