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Indications and Limits of Surgery for Spinal Metastases Derived from Lung Cancer: A Single-Center Experience

Lung cancer is the second most frequently diagnosed cancer in the world, and surgery is an integral part of the treatment for spinal metastases. The aims of this retrospective study were to assess the overall survival of surgically treated patients affected by lung cancer spinal metastases and ident...

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Autores principales: Terzi, Silvia, Trentin, Federica, Griffoni, Cristiana, Carretta, Elisa, Bandiera, Stefano, Ferrari, Cristina, Vita, Fabio, Righi, Alberto, Maioli, Margherita, De Biase, Dario, Monetta, Annalisa, Barbanti Brodano, Giovanni, Evangelisti, Gisberto, Girolami, Marco, Pipola, Valerio, Gambarotti, Marco, Gasbarrini, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296811/
https://www.ncbi.nlm.nih.gov/pubmed/37370988
http://dx.doi.org/10.3390/diagnostics13122093
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author Terzi, Silvia
Trentin, Federica
Griffoni, Cristiana
Carretta, Elisa
Bandiera, Stefano
Ferrari, Cristina
Vita, Fabio
Righi, Alberto
Maioli, Margherita
De Biase, Dario
Monetta, Annalisa
Barbanti Brodano, Giovanni
Evangelisti, Gisberto
Girolami, Marco
Pipola, Valerio
Gambarotti, Marco
Gasbarrini, Alessandro
author_facet Terzi, Silvia
Trentin, Federica
Griffoni, Cristiana
Carretta, Elisa
Bandiera, Stefano
Ferrari, Cristina
Vita, Fabio
Righi, Alberto
Maioli, Margherita
De Biase, Dario
Monetta, Annalisa
Barbanti Brodano, Giovanni
Evangelisti, Gisberto
Girolami, Marco
Pipola, Valerio
Gambarotti, Marco
Gasbarrini, Alessandro
author_sort Terzi, Silvia
collection PubMed
description Lung cancer is the second most frequently diagnosed cancer in the world, and surgery is an integral part of the treatment for spinal metastases. The aims of this retrospective study were to assess the overall survival of surgically treated patients affected by lung cancer spinal metastases and identify any factors related to a better survival rate. We recruited 56 consecutive patients (34 male and 22 female) surgically treated for metastatic lung cancer in the spine from 2009 to 2019. Surgical indications were based on a previously published and validated flow chart following a multidisciplinary evaluation. We assessed the localization of vertebral metastases, the presence of other bone or visceral metastases, neurological status according to the Frankel score, ambulatory autonomy, and general status, measured with the Karnofsky performance scale. The expected prognosis was retrospectively assessed according to the revised Tokuhashi score. The median survival was 8.1 months, with over a third of patients surviving more than 1 year. We observed a global improvement in all clinical parameters after surgical treatment. The Tokuhashi predictive score did not correlate with survival after surgery. The results of this study suggest that the surgical treatment of symptomatic spinal metastases from lung cancer can improve quality of life, even in patients with a shorter life expectancy, by controlling pain and improving autonomy.
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spelling pubmed-102968112023-06-28 Indications and Limits of Surgery for Spinal Metastases Derived from Lung Cancer: A Single-Center Experience Terzi, Silvia Trentin, Federica Griffoni, Cristiana Carretta, Elisa Bandiera, Stefano Ferrari, Cristina Vita, Fabio Righi, Alberto Maioli, Margherita De Biase, Dario Monetta, Annalisa Barbanti Brodano, Giovanni Evangelisti, Gisberto Girolami, Marco Pipola, Valerio Gambarotti, Marco Gasbarrini, Alessandro Diagnostics (Basel) Article Lung cancer is the second most frequently diagnosed cancer in the world, and surgery is an integral part of the treatment for spinal metastases. The aims of this retrospective study were to assess the overall survival of surgically treated patients affected by lung cancer spinal metastases and identify any factors related to a better survival rate. We recruited 56 consecutive patients (34 male and 22 female) surgically treated for metastatic lung cancer in the spine from 2009 to 2019. Surgical indications were based on a previously published and validated flow chart following a multidisciplinary evaluation. We assessed the localization of vertebral metastases, the presence of other bone or visceral metastases, neurological status according to the Frankel score, ambulatory autonomy, and general status, measured with the Karnofsky performance scale. The expected prognosis was retrospectively assessed according to the revised Tokuhashi score. The median survival was 8.1 months, with over a third of patients surviving more than 1 year. We observed a global improvement in all clinical parameters after surgical treatment. The Tokuhashi predictive score did not correlate with survival after surgery. The results of this study suggest that the surgical treatment of symptomatic spinal metastases from lung cancer can improve quality of life, even in patients with a shorter life expectancy, by controlling pain and improving autonomy. MDPI 2023-06-16 /pmc/articles/PMC10296811/ /pubmed/37370988 http://dx.doi.org/10.3390/diagnostics13122093 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Terzi, Silvia
Trentin, Federica
Griffoni, Cristiana
Carretta, Elisa
Bandiera, Stefano
Ferrari, Cristina
Vita, Fabio
Righi, Alberto
Maioli, Margherita
De Biase, Dario
Monetta, Annalisa
Barbanti Brodano, Giovanni
Evangelisti, Gisberto
Girolami, Marco
Pipola, Valerio
Gambarotti, Marco
Gasbarrini, Alessandro
Indications and Limits of Surgery for Spinal Metastases Derived from Lung Cancer: A Single-Center Experience
title Indications and Limits of Surgery for Spinal Metastases Derived from Lung Cancer: A Single-Center Experience
title_full Indications and Limits of Surgery for Spinal Metastases Derived from Lung Cancer: A Single-Center Experience
title_fullStr Indications and Limits of Surgery for Spinal Metastases Derived from Lung Cancer: A Single-Center Experience
title_full_unstemmed Indications and Limits of Surgery for Spinal Metastases Derived from Lung Cancer: A Single-Center Experience
title_short Indications and Limits of Surgery for Spinal Metastases Derived from Lung Cancer: A Single-Center Experience
title_sort indications and limits of surgery for spinal metastases derived from lung cancer: a single-center experience
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296811/
https://www.ncbi.nlm.nih.gov/pubmed/37370988
http://dx.doi.org/10.3390/diagnostics13122093
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