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The Impact of O6-Methylguanine-DNA Methyltransferase (MGMT) Promoter Methylation on the Outcomes of Patients with Leiomyosarcoma Treated with Dacarbazine

Dacarbazine is an important drug in the therapeutic landscape of leiomyosarcoma (LMS). Alkylating agents are subjected to resistance mechanisms based on anti-apoptotic pathways and repair mechanisms, including the DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT). In this retrospective...

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Detalles Bibliográficos
Autores principales:	Cannella, Lucia, Della Monica, Rosa, Marretta, Antonella Lucia, Iervolino, Domenico, Vincenzi, Bruno, De Chiara, Anna Rosaria, Clemente, Ottavia, Buonaiuto, Michela, Barretta, Maria Luisa, Di Mauro, Annabella, Di Marzo, Massimiliano, Guida, Michele, Badalamenti, Giuseppe, Chiariotti, Lorenzo, Tafuto, Salvatore
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296876/ https://www.ncbi.nlm.nih.gov/pubmed/37371106 http://dx.doi.org/10.3390/cells12121635

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