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GPCR Binding and JNK3 Activation by Arrestin-3 Have Different Structural Requirements

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Arrestins bind active phosphorylated G protein-coupled receptors (GPCRs). Among the four mammalian subtypes, only arrestin-3 facilitates the activation of JNK3 in cells. In available structures, Lys-295 in the lariat loop of arrestin-3 and its homologue Lys-294 in arrestin-2 directly interact with t...

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Detalles Bibliográficos
Autores principales:	Zheng, Chen, Weinstein, Liana D., Nguyen, Kevin K., Grewal, Abhijeet, Gurevich, Eugenia V., Gurevich, Vsevolod V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296906/ https://www.ncbi.nlm.nih.gov/pubmed/37371033 http://dx.doi.org/10.3390/cells12121563

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