Cargando…

Systematic Review of Calcineurin Inhibitors and Incidence of Skin Malignancies after Kidney Transplantation in Adult Patients: A Study of 309,551 Cases

The purpose of this systematic review and meta-analysis was to compare the risk of non-melanoma skin cancer (NMSC) and melanoma development in renal transplant recipients who receive calcineurin inhibitors to that of patients treated with other immunosuppressive agents, and investigate the possible...

Descripción completa

Detalles Bibliográficos
Autores principales: Kulbat, Aleksandra, Richter, Karolina, Stefura, Tomasz, Kołodziej-Rzepa, Marta, Kisielewski, Michał, Wojewoda, Tomasz, Wysocki, Wojciech M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296938/
https://www.ncbi.nlm.nih.gov/pubmed/37366913
http://dx.doi.org/10.3390/curroncol30060430
_version_ 1785063766060171264
author Kulbat, Aleksandra
Richter, Karolina
Stefura, Tomasz
Kołodziej-Rzepa, Marta
Kisielewski, Michał
Wojewoda, Tomasz
Wysocki, Wojciech M.
author_facet Kulbat, Aleksandra
Richter, Karolina
Stefura, Tomasz
Kołodziej-Rzepa, Marta
Kisielewski, Michał
Wojewoda, Tomasz
Wysocki, Wojciech M.
author_sort Kulbat, Aleksandra
collection PubMed
description The purpose of this systematic review and meta-analysis was to compare the risk of non-melanoma skin cancer (NMSC) and melanoma development in renal transplant recipients who receive calcineurin inhibitors to that of patients treated with other immunosuppressive agents, and investigate the possible association between the type of maintenance immunosuppression and the incidence of NSMC and melanoma in this group of patients. The authors searched databases such as PubMed, Scopus, and Web of Science for articles that would help establish the influence of calcineurin inhibitors on skin cancer development. The inclusion criteria for the study consisted of randomized clinical trials, cohort studies, and case-control studies that compared patients who received kidney transplants and were treated with a calcineurin inhibitor (CNI), such as cyclosporine A (CsA) or tacrolimus (Tac), to those who received alternative immunosuppressants and did not receive a CNI. Seven articles were analyzed overall. The results revealed a correlation between CNI treatment in renal transplant recipients and increased total skin cancer risk (OR 1.28; 95% CI: 0.10–16.28; p < 0.01), melanoma risk (OR 1.09; 95% CI: 0.25–4.74; p < 0.01), and NMSC risk (OR 1.16; 95% CI: 0.41–3.26; p < 0.01). In conclusion, the calcineurin inhibitors used after kidney transplantation are associated with a higher risk of skin cancer—both non-melanoma and melanoma—when compared with other immunosuppressive therapies. This finding suggests that careful monitoring for skin lesions in post-transplant patients must be conducted. However, the decision on the kind of immunotherapy used should always be considered on an individual basis for each renal transplant recipient.
format Online
Article
Text
id pubmed-10296938
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102969382023-06-28 Systematic Review of Calcineurin Inhibitors and Incidence of Skin Malignancies after Kidney Transplantation in Adult Patients: A Study of 309,551 Cases Kulbat, Aleksandra Richter, Karolina Stefura, Tomasz Kołodziej-Rzepa, Marta Kisielewski, Michał Wojewoda, Tomasz Wysocki, Wojciech M. Curr Oncol Systematic Review The purpose of this systematic review and meta-analysis was to compare the risk of non-melanoma skin cancer (NMSC) and melanoma development in renal transplant recipients who receive calcineurin inhibitors to that of patients treated with other immunosuppressive agents, and investigate the possible association between the type of maintenance immunosuppression and the incidence of NSMC and melanoma in this group of patients. The authors searched databases such as PubMed, Scopus, and Web of Science for articles that would help establish the influence of calcineurin inhibitors on skin cancer development. The inclusion criteria for the study consisted of randomized clinical trials, cohort studies, and case-control studies that compared patients who received kidney transplants and were treated with a calcineurin inhibitor (CNI), such as cyclosporine A (CsA) or tacrolimus (Tac), to those who received alternative immunosuppressants and did not receive a CNI. Seven articles were analyzed overall. The results revealed a correlation between CNI treatment in renal transplant recipients and increased total skin cancer risk (OR 1.28; 95% CI: 0.10–16.28; p < 0.01), melanoma risk (OR 1.09; 95% CI: 0.25–4.74; p < 0.01), and NMSC risk (OR 1.16; 95% CI: 0.41–3.26; p < 0.01). In conclusion, the calcineurin inhibitors used after kidney transplantation are associated with a higher risk of skin cancer—both non-melanoma and melanoma—when compared with other immunosuppressive therapies. This finding suggests that careful monitoring for skin lesions in post-transplant patients must be conducted. However, the decision on the kind of immunotherapy used should always be considered on an individual basis for each renal transplant recipient. MDPI 2023-06-13 /pmc/articles/PMC10296938/ /pubmed/37366913 http://dx.doi.org/10.3390/curroncol30060430 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Kulbat, Aleksandra
Richter, Karolina
Stefura, Tomasz
Kołodziej-Rzepa, Marta
Kisielewski, Michał
Wojewoda, Tomasz
Wysocki, Wojciech M.
Systematic Review of Calcineurin Inhibitors and Incidence of Skin Malignancies after Kidney Transplantation in Adult Patients: A Study of 309,551 Cases
title Systematic Review of Calcineurin Inhibitors and Incidence of Skin Malignancies after Kidney Transplantation in Adult Patients: A Study of 309,551 Cases
title_full Systematic Review of Calcineurin Inhibitors and Incidence of Skin Malignancies after Kidney Transplantation in Adult Patients: A Study of 309,551 Cases
title_fullStr Systematic Review of Calcineurin Inhibitors and Incidence of Skin Malignancies after Kidney Transplantation in Adult Patients: A Study of 309,551 Cases
title_full_unstemmed Systematic Review of Calcineurin Inhibitors and Incidence of Skin Malignancies after Kidney Transplantation in Adult Patients: A Study of 309,551 Cases
title_short Systematic Review of Calcineurin Inhibitors and Incidence of Skin Malignancies after Kidney Transplantation in Adult Patients: A Study of 309,551 Cases
title_sort systematic review of calcineurin inhibitors and incidence of skin malignancies after kidney transplantation in adult patients: a study of 309,551 cases
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296938/
https://www.ncbi.nlm.nih.gov/pubmed/37366913
http://dx.doi.org/10.3390/curroncol30060430
work_keys_str_mv AT kulbataleksandra systematicreviewofcalcineurininhibitorsandincidenceofskinmalignanciesafterkidneytransplantationinadultpatientsastudyof309551cases
AT richterkarolina systematicreviewofcalcineurininhibitorsandincidenceofskinmalignanciesafterkidneytransplantationinadultpatientsastudyof309551cases
AT stefuratomasz systematicreviewofcalcineurininhibitorsandincidenceofskinmalignanciesafterkidneytransplantationinadultpatientsastudyof309551cases
AT kołodziejrzepamarta systematicreviewofcalcineurininhibitorsandincidenceofskinmalignanciesafterkidneytransplantationinadultpatientsastudyof309551cases
AT kisielewskimichał systematicreviewofcalcineurininhibitorsandincidenceofskinmalignanciesafterkidneytransplantationinadultpatientsastudyof309551cases
AT wojewodatomasz systematicreviewofcalcineurininhibitorsandincidenceofskinmalignanciesafterkidneytransplantationinadultpatientsastudyof309551cases
AT wysockiwojciechm systematicreviewofcalcineurininhibitorsandincidenceofskinmalignanciesafterkidneytransplantationinadultpatientsastudyof309551cases