Phospholipid Encapsulation of an Anti-Fibrotic Endopeptide to Enhance Cellular Uptake and Myocardial Retention

Background: Cardioprotective effects of N-acetyl-ser-asp-lys-pro (Ac-SDKP) have been reported in preclinical models of myocardial remodeling. However, the rapid degradation of this endogenous peptide in vivo limits its clinical use. Method: To prolong its bioavailability, Ac-SDKP was encapsulated by...

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Detalles Bibliográficos
Autores principales: Sonkawade, Swati D., Xu, Shirley, Kim, Minhyung, Nepali, Sarmila, Karambizi, Victoire-Grace, Sexton, Sandra, Turowski, Steven G., Li, Kunpeng, Spernyak, Joseph A., Lovell, Jonathan F., George, Anthony, Suwal, Sujit, Sharma, Umesh C., Pokharel, Saraswati
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296995/
https://www.ncbi.nlm.nih.gov/pubmed/37371059
http://dx.doi.org/10.3390/cells12121589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296995/
https://www.ncbi.nlm.nih.gov/pubmed/37371059
http://dx.doi.org/10.3390/cells12121589

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