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Detection of Biomarker Using Aptasensors to Determine the Type of Diabetes

Diabetes mellitus (DM) is a metabolic disorder characterized by elevated blood glucose levels. This disease is so serious that many experts refer to it as the “silent killer”. The early detection of diabetes mellitus, whether type 1, type 2 or mitochondrial, is crucial because it can improve the suc...

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Autores principales: Mulyani, Dinda Exelsa, Maksum, Iman Permana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297103/
https://www.ncbi.nlm.nih.gov/pubmed/37370930
http://dx.doi.org/10.3390/diagnostics13122035
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author Mulyani, Dinda Exelsa
Maksum, Iman Permana
author_facet Mulyani, Dinda Exelsa
Maksum, Iman Permana
author_sort Mulyani, Dinda Exelsa
collection PubMed
description Diabetes mellitus (DM) is a metabolic disorder characterized by elevated blood glucose levels. This disease is so serious that many experts refer to it as the “silent killer”. The early detection of diabetes mellitus, whether type 1, type 2 or mitochondrial, is crucial because it can improve the success of treatment and the quality of life for patients. Aptamer-based biosensor diagnosis methods have been widely developed because they have high sensitivity and selectivity in detecting biomarkers of various diseases. Aptamers are short sequences of oligonucleotides or proteins that recognize specific ligands and bind to various target molecules, ranging from small ions to large proteins. They are promising diagnostic molecules due to their high sensitivity and selectivity, ease of modification, low toxicity, and high stability. This article aims to summarize the progress of detection methods, including detection principles, sensitivity, selectivity, and the performance of detection devices, to distinguish between types of diabetes mellitus using electrochemical aptasensors with biomarkers such as glucose, insulin, HbA1c, GHSA, and ATP.
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spelling pubmed-102971032023-06-28 Detection of Biomarker Using Aptasensors to Determine the Type of Diabetes Mulyani, Dinda Exelsa Maksum, Iman Permana Diagnostics (Basel) Review Diabetes mellitus (DM) is a metabolic disorder characterized by elevated blood glucose levels. This disease is so serious that many experts refer to it as the “silent killer”. The early detection of diabetes mellitus, whether type 1, type 2 or mitochondrial, is crucial because it can improve the success of treatment and the quality of life for patients. Aptamer-based biosensor diagnosis methods have been widely developed because they have high sensitivity and selectivity in detecting biomarkers of various diseases. Aptamers are short sequences of oligonucleotides or proteins that recognize specific ligands and bind to various target molecules, ranging from small ions to large proteins. They are promising diagnostic molecules due to their high sensitivity and selectivity, ease of modification, low toxicity, and high stability. This article aims to summarize the progress of detection methods, including detection principles, sensitivity, selectivity, and the performance of detection devices, to distinguish between types of diabetes mellitus using electrochemical aptasensors with biomarkers such as glucose, insulin, HbA1c, GHSA, and ATP. MDPI 2023-06-12 /pmc/articles/PMC10297103/ /pubmed/37370930 http://dx.doi.org/10.3390/diagnostics13122035 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mulyani, Dinda Exelsa
Maksum, Iman Permana
Detection of Biomarker Using Aptasensors to Determine the Type of Diabetes
title Detection of Biomarker Using Aptasensors to Determine the Type of Diabetes
title_full Detection of Biomarker Using Aptasensors to Determine the Type of Diabetes
title_fullStr Detection of Biomarker Using Aptasensors to Determine the Type of Diabetes
title_full_unstemmed Detection of Biomarker Using Aptasensors to Determine the Type of Diabetes
title_short Detection of Biomarker Using Aptasensors to Determine the Type of Diabetes
title_sort detection of biomarker using aptasensors to determine the type of diabetes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297103/
https://www.ncbi.nlm.nih.gov/pubmed/37370930
http://dx.doi.org/10.3390/diagnostics13122035
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