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Intrathymic Localization of Melanoma: A Brief Report of Two Cases and a Review of the Literature
Intrathymic localizations of melanoma represent a very rare entity, with fewer than ten cases of intrathymic melanoma described in the literature. Herein, we describe two cases of patients who underwent surgical removal of a thymic mass at our thoracic surgery department between 2015 and 2022. The f...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297109/ https://www.ncbi.nlm.nih.gov/pubmed/37370911 http://dx.doi.org/10.3390/diagnostics13122017 |
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author | Cannone, Giorgio Verzeletti, Vincenzo Fortarezza, Francesco Pezzuto, Federica Polverosi, Roberta Faccioli, Eleonora Comacchio, Giovanni Maria Dell’Amore, Andrea Rea, Federico Schiavon, Marco Calabrese, Fiorella |
author_facet | Cannone, Giorgio Verzeletti, Vincenzo Fortarezza, Francesco Pezzuto, Federica Polverosi, Roberta Faccioli, Eleonora Comacchio, Giovanni Maria Dell’Amore, Andrea Rea, Federico Schiavon, Marco Calabrese, Fiorella |
author_sort | Cannone, Giorgio |
collection | PubMed |
description | Intrathymic localizations of melanoma represent a very rare entity, with fewer than ten cases of intrathymic melanoma described in the literature. Herein, we describe two cases of patients who underwent surgical removal of a thymic mass at our thoracic surgery department between 2015 and 2022. The final pathological examination revealed a malignant melanoma in both cases; we therefore carried out a literature review to identify such rare and similar cases. In the first case, the intrathymic localization of melanoma was the first manifestation of the disease, posing a dilemma regarding the metastatic and primitive nature of the neoplasm. The second case described a thymic metastasis from a known previous cutaneous melanoma, for which the patient had successfully been treated six years earlier. After carefully reviewing the literature, we identified only six cases of verified primary intrathymic melanomas and one case of intrathymic metastasis resulting from melanoma previously described. Pathologists should be aware of the occurrence of this rare entity and mindful of the differential diagnoses. Several tools, including immunostaining of melanocytic markers and molecular investigations, are mandatory for final pathological diagnosis. |
format | Online Article Text |
id | pubmed-10297109 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102971092023-06-28 Intrathymic Localization of Melanoma: A Brief Report of Two Cases and a Review of the Literature Cannone, Giorgio Verzeletti, Vincenzo Fortarezza, Francesco Pezzuto, Federica Polverosi, Roberta Faccioli, Eleonora Comacchio, Giovanni Maria Dell’Amore, Andrea Rea, Federico Schiavon, Marco Calabrese, Fiorella Diagnostics (Basel) Case Report Intrathymic localizations of melanoma represent a very rare entity, with fewer than ten cases of intrathymic melanoma described in the literature. Herein, we describe two cases of patients who underwent surgical removal of a thymic mass at our thoracic surgery department between 2015 and 2022. The final pathological examination revealed a malignant melanoma in both cases; we therefore carried out a literature review to identify such rare and similar cases. In the first case, the intrathymic localization of melanoma was the first manifestation of the disease, posing a dilemma regarding the metastatic and primitive nature of the neoplasm. The second case described a thymic metastasis from a known previous cutaneous melanoma, for which the patient had successfully been treated six years earlier. After carefully reviewing the literature, we identified only six cases of verified primary intrathymic melanomas and one case of intrathymic metastasis resulting from melanoma previously described. Pathologists should be aware of the occurrence of this rare entity and mindful of the differential diagnoses. Several tools, including immunostaining of melanocytic markers and molecular investigations, are mandatory for final pathological diagnosis. MDPI 2023-06-09 /pmc/articles/PMC10297109/ /pubmed/37370911 http://dx.doi.org/10.3390/diagnostics13122017 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Cannone, Giorgio Verzeletti, Vincenzo Fortarezza, Francesco Pezzuto, Federica Polverosi, Roberta Faccioli, Eleonora Comacchio, Giovanni Maria Dell’Amore, Andrea Rea, Federico Schiavon, Marco Calabrese, Fiorella Intrathymic Localization of Melanoma: A Brief Report of Two Cases and a Review of the Literature |
title | Intrathymic Localization of Melanoma: A Brief Report of Two Cases and a Review of the Literature |
title_full | Intrathymic Localization of Melanoma: A Brief Report of Two Cases and a Review of the Literature |
title_fullStr | Intrathymic Localization of Melanoma: A Brief Report of Two Cases and a Review of the Literature |
title_full_unstemmed | Intrathymic Localization of Melanoma: A Brief Report of Two Cases and a Review of the Literature |
title_short | Intrathymic Localization of Melanoma: A Brief Report of Two Cases and a Review of the Literature |
title_sort | intrathymic localization of melanoma: a brief report of two cases and a review of the literature |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297109/ https://www.ncbi.nlm.nih.gov/pubmed/37370911 http://dx.doi.org/10.3390/diagnostics13122017 |
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