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A Decade of Therapeutic Challenges in Synchronous Gynecological Cancers from the Bucharest Oncological Institute

The aim of our study is to present the particularities of a specific subset of gynecological cancer patients in Romania. We present a review of synchronous gynecological neoplasia (SGN) treated in the Bucharest Oncological Institute’s surgery departments over a decade. Between 2012 and 2022, 7419 fe...

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Autores principales: Simion, Laurentiu, Chitoran, Elena, Cirimbei, Ciprian, Stefan, Daniela-Cristina, Neicu, Ariana, Tanase, Bogdan, Ionescu, Sinziana Octavia, Luca, Dan Cristian, Gales, Laurentia, Gheorghe, Adelina Silvana, Stanculeanu, Dana Lucia, Rotaru, Vlad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297116/
https://www.ncbi.nlm.nih.gov/pubmed/37370964
http://dx.doi.org/10.3390/diagnostics13122069
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author Simion, Laurentiu
Chitoran, Elena
Cirimbei, Ciprian
Stefan, Daniela-Cristina
Neicu, Ariana
Tanase, Bogdan
Ionescu, Sinziana Octavia
Luca, Dan Cristian
Gales, Laurentia
Gheorghe, Adelina Silvana
Stanculeanu, Dana Lucia
Rotaru, Vlad
author_facet Simion, Laurentiu
Chitoran, Elena
Cirimbei, Ciprian
Stefan, Daniela-Cristina
Neicu, Ariana
Tanase, Bogdan
Ionescu, Sinziana Octavia
Luca, Dan Cristian
Gales, Laurentia
Gheorghe, Adelina Silvana
Stanculeanu, Dana Lucia
Rotaru, Vlad
author_sort Simion, Laurentiu
collection PubMed
description The aim of our study is to present the particularities of a specific subset of gynecological cancer patients in Romania. We present a review of synchronous gynecological neoplasia (SGN) treated in the Bucharest Oncological Institute’s surgery departments over a decade. Between 2012 and 2022, 7419 female patients with genital malignancies were treated. We identified 36 patients with invasive synchronous primary gynecological cancers (0.5%) and 12 cases with one primary gynecological and another primary invasive pelvic cancer (rectal/bladder). All recurrent, metastatic, or metachronous tumors detected were excluded. Demographic data, personal history, presenting symptoms, pathologic findings, staging, treatment, and evolution for each case were recorded. Usually, the most common SGN association is between ovarian and endometrial cancer of endometrioid differentiation (low-grade malignancies with very good prognosis). However, we noticed that, given the particularities of the Romanian medical system, the most frequent association is between cervical and endometrial, followed by cervical and ovarian cancers. Moreover, the cancer stage at diagnosis is more advanced. In countries with low HPV vaccination rate and low adherence to screening programs, SGNs can present as extremely advanced cases and require extensive surgery (such as pelvic exenterations) to achieve radicality. This multimodal treatment in advanced cases with high tumor burden determines a reduction in survival, time until progression, and quality of life.
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spelling pubmed-102971162023-06-28 A Decade of Therapeutic Challenges in Synchronous Gynecological Cancers from the Bucharest Oncological Institute Simion, Laurentiu Chitoran, Elena Cirimbei, Ciprian Stefan, Daniela-Cristina Neicu, Ariana Tanase, Bogdan Ionescu, Sinziana Octavia Luca, Dan Cristian Gales, Laurentia Gheorghe, Adelina Silvana Stanculeanu, Dana Lucia Rotaru, Vlad Diagnostics (Basel) Article The aim of our study is to present the particularities of a specific subset of gynecological cancer patients in Romania. We present a review of synchronous gynecological neoplasia (SGN) treated in the Bucharest Oncological Institute’s surgery departments over a decade. Between 2012 and 2022, 7419 female patients with genital malignancies were treated. We identified 36 patients with invasive synchronous primary gynecological cancers (0.5%) and 12 cases with one primary gynecological and another primary invasive pelvic cancer (rectal/bladder). All recurrent, metastatic, or metachronous tumors detected were excluded. Demographic data, personal history, presenting symptoms, pathologic findings, staging, treatment, and evolution for each case were recorded. Usually, the most common SGN association is between ovarian and endometrial cancer of endometrioid differentiation (low-grade malignancies with very good prognosis). However, we noticed that, given the particularities of the Romanian medical system, the most frequent association is between cervical and endometrial, followed by cervical and ovarian cancers. Moreover, the cancer stage at diagnosis is more advanced. In countries with low HPV vaccination rate and low adherence to screening programs, SGNs can present as extremely advanced cases and require extensive surgery (such as pelvic exenterations) to achieve radicality. This multimodal treatment in advanced cases with high tumor burden determines a reduction in survival, time until progression, and quality of life. MDPI 2023-06-15 /pmc/articles/PMC10297116/ /pubmed/37370964 http://dx.doi.org/10.3390/diagnostics13122069 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Simion, Laurentiu
Chitoran, Elena
Cirimbei, Ciprian
Stefan, Daniela-Cristina
Neicu, Ariana
Tanase, Bogdan
Ionescu, Sinziana Octavia
Luca, Dan Cristian
Gales, Laurentia
Gheorghe, Adelina Silvana
Stanculeanu, Dana Lucia
Rotaru, Vlad
A Decade of Therapeutic Challenges in Synchronous Gynecological Cancers from the Bucharest Oncological Institute
title A Decade of Therapeutic Challenges in Synchronous Gynecological Cancers from the Bucharest Oncological Institute
title_full A Decade of Therapeutic Challenges in Synchronous Gynecological Cancers from the Bucharest Oncological Institute
title_fullStr A Decade of Therapeutic Challenges in Synchronous Gynecological Cancers from the Bucharest Oncological Institute
title_full_unstemmed A Decade of Therapeutic Challenges in Synchronous Gynecological Cancers from the Bucharest Oncological Institute
title_short A Decade of Therapeutic Challenges in Synchronous Gynecological Cancers from the Bucharest Oncological Institute
title_sort decade of therapeutic challenges in synchronous gynecological cancers from the bucharest oncological institute
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297116/
https://www.ncbi.nlm.nih.gov/pubmed/37370964
http://dx.doi.org/10.3390/diagnostics13122069
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