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TMEM211 Promotes Tumor Progression and Metastasis in Colon Cancer

Colon cancer is the third most important cancer type, leading to a remarkable number of deaths, indicating the necessity of new biomarkers and therapeutic targets for colon cancer patients. Several transmembrane proteins (TMEMs) are associated with tumor progression and cancer malignancy. However, t...

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Autores principales: Chang, Yung-Fu, Wang, Hsing-Hsang, Shu, Chih-Wen, Tsai, Wei-Lun, Lee, Cheng-Hsin, Chen, Chun-Lin, Liu, Pei-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297151/
https://www.ncbi.nlm.nih.gov/pubmed/37367036
http://dx.doi.org/10.3390/cimb45060287
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author Chang, Yung-Fu
Wang, Hsing-Hsang
Shu, Chih-Wen
Tsai, Wei-Lun
Lee, Cheng-Hsin
Chen, Chun-Lin
Liu, Pei-Feng
author_facet Chang, Yung-Fu
Wang, Hsing-Hsang
Shu, Chih-Wen
Tsai, Wei-Lun
Lee, Cheng-Hsin
Chen, Chun-Lin
Liu, Pei-Feng
author_sort Chang, Yung-Fu
collection PubMed
description Colon cancer is the third most important cancer type, leading to a remarkable number of deaths, indicating the necessity of new biomarkers and therapeutic targets for colon cancer patients. Several transmembrane proteins (TMEMs) are associated with tumor progression and cancer malignancy. However, the clinical significance and biological roles of TMEM211 in cancer, especially in colon cancer, are still unknown. In this study, we found that TMEM211 was highly expressed in tumor tissues and the increased TMEM211 was associated with poor prognosis in colon cancer patients from The Cancer Genome Atlas (TCGA) database. We also showed that abilities regarding migration and invasion were reduced in TMEM211-silenced colon cancer cells (HCT116 and DLD-1). Moreover, TMEM211-silenced colon cancer cells showed decreased levels of Twist1, N-cadherin, Snail and Slug but increased levels of E-cadherin. Levels of phosphorylated ERK, AKT and RelA (NF-κB p65) were also decreased in TMEM211-silenced colon cancer cells. Our findings indicate that TMEM211 regulates epithelial–mesenchymal transition for metastasis through coactivating the ERK, AKT and NF-κB signaling pathways, which might provide a potential prognostic biomarker or therapeutic target for colon cancer patients in the future.
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spelling pubmed-102971512023-06-28 TMEM211 Promotes Tumor Progression and Metastasis in Colon Cancer Chang, Yung-Fu Wang, Hsing-Hsang Shu, Chih-Wen Tsai, Wei-Lun Lee, Cheng-Hsin Chen, Chun-Lin Liu, Pei-Feng Curr Issues Mol Biol Article Colon cancer is the third most important cancer type, leading to a remarkable number of deaths, indicating the necessity of new biomarkers and therapeutic targets for colon cancer patients. Several transmembrane proteins (TMEMs) are associated with tumor progression and cancer malignancy. However, the clinical significance and biological roles of TMEM211 in cancer, especially in colon cancer, are still unknown. In this study, we found that TMEM211 was highly expressed in tumor tissues and the increased TMEM211 was associated with poor prognosis in colon cancer patients from The Cancer Genome Atlas (TCGA) database. We also showed that abilities regarding migration and invasion were reduced in TMEM211-silenced colon cancer cells (HCT116 and DLD-1). Moreover, TMEM211-silenced colon cancer cells showed decreased levels of Twist1, N-cadherin, Snail and Slug but increased levels of E-cadherin. Levels of phosphorylated ERK, AKT and RelA (NF-κB p65) were also decreased in TMEM211-silenced colon cancer cells. Our findings indicate that TMEM211 regulates epithelial–mesenchymal transition for metastasis through coactivating the ERK, AKT and NF-κB signaling pathways, which might provide a potential prognostic biomarker or therapeutic target for colon cancer patients in the future. MDPI 2023-05-24 /pmc/articles/PMC10297151/ /pubmed/37367036 http://dx.doi.org/10.3390/cimb45060287 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chang, Yung-Fu
Wang, Hsing-Hsang
Shu, Chih-Wen
Tsai, Wei-Lun
Lee, Cheng-Hsin
Chen, Chun-Lin
Liu, Pei-Feng
TMEM211 Promotes Tumor Progression and Metastasis in Colon Cancer
title TMEM211 Promotes Tumor Progression and Metastasis in Colon Cancer
title_full TMEM211 Promotes Tumor Progression and Metastasis in Colon Cancer
title_fullStr TMEM211 Promotes Tumor Progression and Metastasis in Colon Cancer
title_full_unstemmed TMEM211 Promotes Tumor Progression and Metastasis in Colon Cancer
title_short TMEM211 Promotes Tumor Progression and Metastasis in Colon Cancer
title_sort tmem211 promotes tumor progression and metastasis in colon cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297151/
https://www.ncbi.nlm.nih.gov/pubmed/37367036
http://dx.doi.org/10.3390/cimb45060287
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