Astrocytes Differentiated from LRRK2-I1371V Parkinson’s-Disease-Induced Pluripotent Stem Cells Exhibit Similar Yield but Cell-Intrinsic Dysfunction in Glutamate Uptake and Metabolism, ATP Generation, and Nrf2-Mediated Glutathione Machinery

Owing to the presence of multiple enzymatic domains, LRRK2 has been associated with a diverse set of cellular functions and signaling pathways. It also has several pathological mutant-variants, and their incidences show ethnicity biases and drug-response differences with expression in dopaminergic-n...

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Detalles Bibliográficos
Autores principales: Banerjee, Roon, Raj, Aishwarya, Potdar, Chandrakanta, Kumar Pal, Pramod, Yadav, Ravi, Kamble, Nitish, Holla, Vikram, Datta, Indrani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297190/
https://www.ncbi.nlm.nih.gov/pubmed/37371062
http://dx.doi.org/10.3390/cells12121592

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