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Analysis of Plasma Proteins Involved in Inflammation, Immune Response/Complement System, and Blood Coagulation upon Admission of COVID-19 Patients to Hospital May Help to Predict the Prognosis of the Disease
The development of new approaches allowing for the early assessment of COVID-19 cases that are likely to become critical and the discovery of new therapeutic targets are urgently required. In this prospective cohort study, we performed proteomic and laboratory profiling of plasma from 163 COVID-19 p...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297236/ https://www.ncbi.nlm.nih.gov/pubmed/37371071 http://dx.doi.org/10.3390/cells12121601 |
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author | di Flora, Daniele Castro Dionizio, Aline Pereira, Heloisa Aparecida Barbosa Silva Garbieri, Thais Francini Grizzo, Larissa Tercilia Dionisio, Thiago José Leite, Aline de Lima Silva-Costa, Licia C. Buzalaf, Nathalia Rabelo Reis, Fernanda Navas Pereira, Virginia Bodelão Richini Rosa, Deborah Maciel Cavalcanti dos Santos, Carlos Ferreira Buzalaf, Marília Afonso Rabelo |
author_facet | di Flora, Daniele Castro Dionizio, Aline Pereira, Heloisa Aparecida Barbosa Silva Garbieri, Thais Francini Grizzo, Larissa Tercilia Dionisio, Thiago José Leite, Aline de Lima Silva-Costa, Licia C. Buzalaf, Nathalia Rabelo Reis, Fernanda Navas Pereira, Virginia Bodelão Richini Rosa, Deborah Maciel Cavalcanti dos Santos, Carlos Ferreira Buzalaf, Marília Afonso Rabelo |
author_sort | di Flora, Daniele Castro |
collection | PubMed |
description | The development of new approaches allowing for the early assessment of COVID-19 cases that are likely to become critical and the discovery of new therapeutic targets are urgently required. In this prospective cohort study, we performed proteomic and laboratory profiling of plasma from 163 COVID-19 patients admitted to Bauru State Hospital (Brazil) between 4 May 2020 and 4 July 2020. Plasma samples were collected upon admission for routine laboratory analyses and shotgun quantitative label-free proteomics. Based on the course of the disease, the patients were divided into three groups: (a) mild (n = 76) and (b) severe (n = 56) symptoms, whose patients were discharged without or with admission to an intensive care unit (ICU), respectively, and (c) critical (n = 31), a group consisting of patients who died after admission to an ICU. Based on our data, potential therapies for COVID-19 should target proteins involved in inflammation, the immune response and complement system, and blood coagulation. Other proteins that could potentially be employed in therapies against COVID-19 but that so far have not been associated with the disease are CD5L, VDBP, A1BG, C4BPA, PGLYRP2, SERPINC1, and APOH. Targeting these proteins’ pathways might constitute potential new therapies or biomarkers of prognosis of the disease. |
format | Online Article Text |
id | pubmed-10297236 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102972362023-06-28 Analysis of Plasma Proteins Involved in Inflammation, Immune Response/Complement System, and Blood Coagulation upon Admission of COVID-19 Patients to Hospital May Help to Predict the Prognosis of the Disease di Flora, Daniele Castro Dionizio, Aline Pereira, Heloisa Aparecida Barbosa Silva Garbieri, Thais Francini Grizzo, Larissa Tercilia Dionisio, Thiago José Leite, Aline de Lima Silva-Costa, Licia C. Buzalaf, Nathalia Rabelo Reis, Fernanda Navas Pereira, Virginia Bodelão Richini Rosa, Deborah Maciel Cavalcanti dos Santos, Carlos Ferreira Buzalaf, Marília Afonso Rabelo Cells Article The development of new approaches allowing for the early assessment of COVID-19 cases that are likely to become critical and the discovery of new therapeutic targets are urgently required. In this prospective cohort study, we performed proteomic and laboratory profiling of plasma from 163 COVID-19 patients admitted to Bauru State Hospital (Brazil) between 4 May 2020 and 4 July 2020. Plasma samples were collected upon admission for routine laboratory analyses and shotgun quantitative label-free proteomics. Based on the course of the disease, the patients were divided into three groups: (a) mild (n = 76) and (b) severe (n = 56) symptoms, whose patients were discharged without or with admission to an intensive care unit (ICU), respectively, and (c) critical (n = 31), a group consisting of patients who died after admission to an ICU. Based on our data, potential therapies for COVID-19 should target proteins involved in inflammation, the immune response and complement system, and blood coagulation. Other proteins that could potentially be employed in therapies against COVID-19 but that so far have not been associated with the disease are CD5L, VDBP, A1BG, C4BPA, PGLYRP2, SERPINC1, and APOH. Targeting these proteins’ pathways might constitute potential new therapies or biomarkers of prognosis of the disease. MDPI 2023-06-10 /pmc/articles/PMC10297236/ /pubmed/37371071 http://dx.doi.org/10.3390/cells12121601 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article di Flora, Daniele Castro Dionizio, Aline Pereira, Heloisa Aparecida Barbosa Silva Garbieri, Thais Francini Grizzo, Larissa Tercilia Dionisio, Thiago José Leite, Aline de Lima Silva-Costa, Licia C. Buzalaf, Nathalia Rabelo Reis, Fernanda Navas Pereira, Virginia Bodelão Richini Rosa, Deborah Maciel Cavalcanti dos Santos, Carlos Ferreira Buzalaf, Marília Afonso Rabelo Analysis of Plasma Proteins Involved in Inflammation, Immune Response/Complement System, and Blood Coagulation upon Admission of COVID-19 Patients to Hospital May Help to Predict the Prognosis of the Disease |
title | Analysis of Plasma Proteins Involved in Inflammation, Immune Response/Complement System, and Blood Coagulation upon Admission of COVID-19 Patients to Hospital May Help to Predict the Prognosis of the Disease |
title_full | Analysis of Plasma Proteins Involved in Inflammation, Immune Response/Complement System, and Blood Coagulation upon Admission of COVID-19 Patients to Hospital May Help to Predict the Prognosis of the Disease |
title_fullStr | Analysis of Plasma Proteins Involved in Inflammation, Immune Response/Complement System, and Blood Coagulation upon Admission of COVID-19 Patients to Hospital May Help to Predict the Prognosis of the Disease |
title_full_unstemmed | Analysis of Plasma Proteins Involved in Inflammation, Immune Response/Complement System, and Blood Coagulation upon Admission of COVID-19 Patients to Hospital May Help to Predict the Prognosis of the Disease |
title_short | Analysis of Plasma Proteins Involved in Inflammation, Immune Response/Complement System, and Blood Coagulation upon Admission of COVID-19 Patients to Hospital May Help to Predict the Prognosis of the Disease |
title_sort | analysis of plasma proteins involved in inflammation, immune response/complement system, and blood coagulation upon admission of covid-19 patients to hospital may help to predict the prognosis of the disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297236/ https://www.ncbi.nlm.nih.gov/pubmed/37371071 http://dx.doi.org/10.3390/cells12121601 |
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