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2021/22 and 2022/23 Post-Pandemic Bronchiolitis Seasons in Two Major Italian Cities: A Prospective Study

Objectives: Bronchiolitis remains a major cause of morbidity and mortality in children under 24 months. During the first year of the pandemic, non-pharmacological interventions resulted in a significant reduction of bronchiolitis cases. Early in 2021, a rebound of bronchiolitis was reported with a d...

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Autores principales: Camporesi, Anna, Morello, Rosa, Pierucci, Ugo Maria, Proli, Francesco, Lazzareschi, Ilaria, Bersani, Giulia, Valentini, Piero, Roland, Damian, Buonsenso, Danilo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297298/
https://www.ncbi.nlm.nih.gov/pubmed/37371312
http://dx.doi.org/10.3390/children10061081
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author Camporesi, Anna
Morello, Rosa
Pierucci, Ugo Maria
Proli, Francesco
Lazzareschi, Ilaria
Bersani, Giulia
Valentini, Piero
Roland, Damian
Buonsenso, Danilo
author_facet Camporesi, Anna
Morello, Rosa
Pierucci, Ugo Maria
Proli, Francesco
Lazzareschi, Ilaria
Bersani, Giulia
Valentini, Piero
Roland, Damian
Buonsenso, Danilo
author_sort Camporesi, Anna
collection PubMed
description Objectives: Bronchiolitis remains a major cause of morbidity and mortality in children under 24 months. During the first year of the pandemic, non-pharmacological interventions resulted in a significant reduction of bronchiolitis cases. Early in 2021, a rebound of bronchiolitis was reported with a description of out-of-season outbreaks. In this study, we prospectively evaluated the impact of bronchiolitis in two Italian University centers located in different geographical areas, aiming to compare two post-pandemic bronchiolitis seasons (2021/22 and 2022/23) in terms of severity, outcomes, microbiology and temporal distribution. Methods: This was a bicentric prospective observational cohort study. All consecutive children under 24 months of age assessed in the participating institutions during the specified seasons and receiving a clinical diagnosis of bronchiolitis were included. Results: A total of 900 patients were enrolled. Patients in the second season were globally younger and had comorbidities less often. Temporal distribution changed between the two seasons. Of the patients, 56% were tested for RSV; 60% of these was positive. Patients with RSV were globally younger (3.5 months vs. 4.9, p < 0.001), more often had a need for any kind of respiratory and fluid support and more often needed ward or PICU admission. At the end of the ED visit, 430 patients were discharged home, 372 (41.3%) were admitted to an inpatient ward and 46 (5.1%) to a pediatric intensive care unit. Conclusions: The 2022/23 post-COVID bronchiolitis was mostly similar to that of 2021/22, and was in line with pre-pandemic expectations.
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spelling pubmed-102972982023-06-28 2021/22 and 2022/23 Post-Pandemic Bronchiolitis Seasons in Two Major Italian Cities: A Prospective Study Camporesi, Anna Morello, Rosa Pierucci, Ugo Maria Proli, Francesco Lazzareschi, Ilaria Bersani, Giulia Valentini, Piero Roland, Damian Buonsenso, Danilo Children (Basel) Article Objectives: Bronchiolitis remains a major cause of morbidity and mortality in children under 24 months. During the first year of the pandemic, non-pharmacological interventions resulted in a significant reduction of bronchiolitis cases. Early in 2021, a rebound of bronchiolitis was reported with a description of out-of-season outbreaks. In this study, we prospectively evaluated the impact of bronchiolitis in two Italian University centers located in different geographical areas, aiming to compare two post-pandemic bronchiolitis seasons (2021/22 and 2022/23) in terms of severity, outcomes, microbiology and temporal distribution. Methods: This was a bicentric prospective observational cohort study. All consecutive children under 24 months of age assessed in the participating institutions during the specified seasons and receiving a clinical diagnosis of bronchiolitis were included. Results: A total of 900 patients were enrolled. Patients in the second season were globally younger and had comorbidities less often. Temporal distribution changed between the two seasons. Of the patients, 56% were tested for RSV; 60% of these was positive. Patients with RSV were globally younger (3.5 months vs. 4.9, p < 0.001), more often had a need for any kind of respiratory and fluid support and more often needed ward or PICU admission. At the end of the ED visit, 430 patients were discharged home, 372 (41.3%) were admitted to an inpatient ward and 46 (5.1%) to a pediatric intensive care unit. Conclusions: The 2022/23 post-COVID bronchiolitis was mostly similar to that of 2021/22, and was in line with pre-pandemic expectations. MDPI 2023-06-20 /pmc/articles/PMC10297298/ /pubmed/37371312 http://dx.doi.org/10.3390/children10061081 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Camporesi, Anna
Morello, Rosa
Pierucci, Ugo Maria
Proli, Francesco
Lazzareschi, Ilaria
Bersani, Giulia
Valentini, Piero
Roland, Damian
Buonsenso, Danilo
2021/22 and 2022/23 Post-Pandemic Bronchiolitis Seasons in Two Major Italian Cities: A Prospective Study
title 2021/22 and 2022/23 Post-Pandemic Bronchiolitis Seasons in Two Major Italian Cities: A Prospective Study
title_full 2021/22 and 2022/23 Post-Pandemic Bronchiolitis Seasons in Two Major Italian Cities: A Prospective Study
title_fullStr 2021/22 and 2022/23 Post-Pandemic Bronchiolitis Seasons in Two Major Italian Cities: A Prospective Study
title_full_unstemmed 2021/22 and 2022/23 Post-Pandemic Bronchiolitis Seasons in Two Major Italian Cities: A Prospective Study
title_short 2021/22 and 2022/23 Post-Pandemic Bronchiolitis Seasons in Two Major Italian Cities: A Prospective Study
title_sort 2021/22 and 2022/23 post-pandemic bronchiolitis seasons in two major italian cities: a prospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297298/
https://www.ncbi.nlm.nih.gov/pubmed/37371312
http://dx.doi.org/10.3390/children10061081
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