Association between MGMT Enhancer Methylation and MGMT Promoter Methylation, MGMT Protein Expression, and Overall Survival in Glioblastoma

The repair protein O6-methylguanine-DNA methyltransferase (MGMT) is regulated epigenetically, mainly by the methylation of the MGMT promoter. MGMT promoter methylation status has emerged as a prognostic and predictive biomarker for patients with newly diagnosed glioblastoma (GBM). However, a strong...

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Detalles Bibliográficos
Autores principales: Zappe, Katja, Pühringer, Katharina, Pflug, Simon, Berger, Daniel, Böhm, Andreas, Spiegl-Kreinecker, Sabine, Cichna-Markl, Margit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297309/
https://www.ncbi.nlm.nih.gov/pubmed/37371109
http://dx.doi.org/10.3390/cells12121639

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