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Leveraging Plasma Membrane Repair Therapeutics for Treating Neurodegenerative Diseases

Plasma membrane repair is an essential cellular mechanism that reseals membrane disruptions after a variety of insults, and compromised repair capacity can contribute to the progression of many diseases. Neurodegenerative diseases are marked by membrane damage from many sources, reduced membrane int...

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Detalles Bibliográficos
Autores principales: Bulgart, Hannah R., Goncalves, Isabella, Weisleder, Noah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297337/
https://www.ncbi.nlm.nih.gov/pubmed/37371130
http://dx.doi.org/10.3390/cells12121660
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author Bulgart, Hannah R.
Goncalves, Isabella
Weisleder, Noah
author_facet Bulgart, Hannah R.
Goncalves, Isabella
Weisleder, Noah
author_sort Bulgart, Hannah R.
collection PubMed
description Plasma membrane repair is an essential cellular mechanism that reseals membrane disruptions after a variety of insults, and compromised repair capacity can contribute to the progression of many diseases. Neurodegenerative diseases are marked by membrane damage from many sources, reduced membrane integrity, elevated intracellular calcium concentrations, enhanced reactive oxygen species production, mitochondrial dysfunction, and widespread neuronal death. While the toxic intracellular effects of these changes in cellular physiology have been defined, the specific mechanism of neuronal death in certain neurodegenerative diseases remains unclear. An abundance of recent evidence indicates that neuronal membrane damage and pore formation in the membrane are key contributors to neurodegenerative disease pathogenesis. In this review, we have outlined evidence supporting the hypothesis that membrane damage is a contributor to neurodegenerative diseases and that therapeutically enhancing membrane repair can potentially combat neuronal death.
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spelling pubmed-102973372023-06-28 Leveraging Plasma Membrane Repair Therapeutics for Treating Neurodegenerative Diseases Bulgart, Hannah R. Goncalves, Isabella Weisleder, Noah Cells Review Plasma membrane repair is an essential cellular mechanism that reseals membrane disruptions after a variety of insults, and compromised repair capacity can contribute to the progression of many diseases. Neurodegenerative diseases are marked by membrane damage from many sources, reduced membrane integrity, elevated intracellular calcium concentrations, enhanced reactive oxygen species production, mitochondrial dysfunction, and widespread neuronal death. While the toxic intracellular effects of these changes in cellular physiology have been defined, the specific mechanism of neuronal death in certain neurodegenerative diseases remains unclear. An abundance of recent evidence indicates that neuronal membrane damage and pore formation in the membrane are key contributors to neurodegenerative disease pathogenesis. In this review, we have outlined evidence supporting the hypothesis that membrane damage is a contributor to neurodegenerative diseases and that therapeutically enhancing membrane repair can potentially combat neuronal death. MDPI 2023-06-18 /pmc/articles/PMC10297337/ /pubmed/37371130 http://dx.doi.org/10.3390/cells12121660 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bulgart, Hannah R.
Goncalves, Isabella
Weisleder, Noah
Leveraging Plasma Membrane Repair Therapeutics for Treating Neurodegenerative Diseases
title Leveraging Plasma Membrane Repair Therapeutics for Treating Neurodegenerative Diseases
title_full Leveraging Plasma Membrane Repair Therapeutics for Treating Neurodegenerative Diseases
title_fullStr Leveraging Plasma Membrane Repair Therapeutics for Treating Neurodegenerative Diseases
title_full_unstemmed Leveraging Plasma Membrane Repair Therapeutics for Treating Neurodegenerative Diseases
title_short Leveraging Plasma Membrane Repair Therapeutics for Treating Neurodegenerative Diseases
title_sort leveraging plasma membrane repair therapeutics for treating neurodegenerative diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297337/
https://www.ncbi.nlm.nih.gov/pubmed/37371130
http://dx.doi.org/10.3390/cells12121660
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