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Associations of Clinical and Dosimetric Parameters with Urinary Toxicities after Prostate Brachytherapy: A Long-Term Single-Institution Experience

To examine the association of clinical, treatment, and dose parameters with late urinary toxicity after low-dose-rate brachytherapy (LDR-BT) for prostate cancer, we retrospectively studied patients with prostate cancer who underwent LDR-BT from January 2007 through December 2016. Urinary toxicity wa...

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Autores principales: Ito, Masaya, Makita, Chiyoko, Mori, Takayuki, Takano, Hirota, Kumano, Tomoyasu, Matsuo, Masayuki, Iinuma, Koji, Kawase, Makoto, Nakane, Keita, Nakano, Masahiro, Koie, Takuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297351/
https://www.ncbi.nlm.nih.gov/pubmed/37366909
http://dx.doi.org/10.3390/curroncol30060426
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author Ito, Masaya
Makita, Chiyoko
Mori, Takayuki
Takano, Hirota
Kumano, Tomoyasu
Matsuo, Masayuki
Iinuma, Koji
Kawase, Makoto
Nakane, Keita
Nakano, Masahiro
Koie, Takuya
author_facet Ito, Masaya
Makita, Chiyoko
Mori, Takayuki
Takano, Hirota
Kumano, Tomoyasu
Matsuo, Masayuki
Iinuma, Koji
Kawase, Makoto
Nakane, Keita
Nakano, Masahiro
Koie, Takuya
author_sort Ito, Masaya
collection PubMed
description To examine the association of clinical, treatment, and dose parameters with late urinary toxicity after low-dose-rate brachytherapy (LDR-BT) for prostate cancer, we retrospectively studied patients with prostate cancer who underwent LDR-BT from January 2007 through December 2016. Urinary toxicity was assessed using the International Prostate Symptom Score (IPSS) and Overactive Bladder (OAB) Symptom Score (OABSS). Severe and moderate lower urinary tract symptoms (LUTS) were defined as IPSS ≥ 20 and ≥ 8, respectively; OAB was defined as a nocturnal frequency of ≥ 2 and a total OABSS of ≥ 3. In total, 203 patients (median age: 66 years) were included, with a mean follow-up of 8.4 years after treatment. The IPSS and OABSS worsened after 3 months of treatment; these scores improved to pretreatment levels after 18–36 months in most patients. Patients with a higher baseline IPSS and OABSS had a higher frequency of moderate and severe LUTS and OAB at 24 and 60 months, respectively. LUTS and OAB at 24 and 60 months were not correlated with the dosimetric factors of LDR-BT. Although the rate of long-term urinary toxicities assessed using IPSS and OABSS was low, the baseline scores were related to long-term function. Refining patient selection may further reduce long-term urinary toxicity.
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spelling pubmed-102973512023-06-28 Associations of Clinical and Dosimetric Parameters with Urinary Toxicities after Prostate Brachytherapy: A Long-Term Single-Institution Experience Ito, Masaya Makita, Chiyoko Mori, Takayuki Takano, Hirota Kumano, Tomoyasu Matsuo, Masayuki Iinuma, Koji Kawase, Makoto Nakane, Keita Nakano, Masahiro Koie, Takuya Curr Oncol Article To examine the association of clinical, treatment, and dose parameters with late urinary toxicity after low-dose-rate brachytherapy (LDR-BT) for prostate cancer, we retrospectively studied patients with prostate cancer who underwent LDR-BT from January 2007 through December 2016. Urinary toxicity was assessed using the International Prostate Symptom Score (IPSS) and Overactive Bladder (OAB) Symptom Score (OABSS). Severe and moderate lower urinary tract symptoms (LUTS) were defined as IPSS ≥ 20 and ≥ 8, respectively; OAB was defined as a nocturnal frequency of ≥ 2 and a total OABSS of ≥ 3. In total, 203 patients (median age: 66 years) were included, with a mean follow-up of 8.4 years after treatment. The IPSS and OABSS worsened after 3 months of treatment; these scores improved to pretreatment levels after 18–36 months in most patients. Patients with a higher baseline IPSS and OABSS had a higher frequency of moderate and severe LUTS and OAB at 24 and 60 months, respectively. LUTS and OAB at 24 and 60 months were not correlated with the dosimetric factors of LDR-BT. Although the rate of long-term urinary toxicities assessed using IPSS and OABSS was low, the baseline scores were related to long-term function. Refining patient selection may further reduce long-term urinary toxicity. MDPI 2023-06-09 /pmc/articles/PMC10297351/ /pubmed/37366909 http://dx.doi.org/10.3390/curroncol30060426 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ito, Masaya
Makita, Chiyoko
Mori, Takayuki
Takano, Hirota
Kumano, Tomoyasu
Matsuo, Masayuki
Iinuma, Koji
Kawase, Makoto
Nakane, Keita
Nakano, Masahiro
Koie, Takuya
Associations of Clinical and Dosimetric Parameters with Urinary Toxicities after Prostate Brachytherapy: A Long-Term Single-Institution Experience
title Associations of Clinical and Dosimetric Parameters with Urinary Toxicities after Prostate Brachytherapy: A Long-Term Single-Institution Experience
title_full Associations of Clinical and Dosimetric Parameters with Urinary Toxicities after Prostate Brachytherapy: A Long-Term Single-Institution Experience
title_fullStr Associations of Clinical and Dosimetric Parameters with Urinary Toxicities after Prostate Brachytherapy: A Long-Term Single-Institution Experience
title_full_unstemmed Associations of Clinical and Dosimetric Parameters with Urinary Toxicities after Prostate Brachytherapy: A Long-Term Single-Institution Experience
title_short Associations of Clinical and Dosimetric Parameters with Urinary Toxicities after Prostate Brachytherapy: A Long-Term Single-Institution Experience
title_sort associations of clinical and dosimetric parameters with urinary toxicities after prostate brachytherapy: a long-term single-institution experience
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297351/
https://www.ncbi.nlm.nih.gov/pubmed/37366909
http://dx.doi.org/10.3390/curroncol30060426
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