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A Rare Complication of Ascariasis: A Case of Acute Interstitial Nephritis
Acute interstitial nephritis (AIN) due to helminths is a rare cause of acute kidney injury (AKI). Helminthiases often progresses insidiously, making diagnosis difficult. This was the case of a 72-year-old man, who presented with renal failure, itching and diarrhoea. Urinalysis revealed leukocyturia,...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297354/ https://www.ncbi.nlm.nih.gov/pubmed/37370949 http://dx.doi.org/10.3390/diagnostics13122054 |
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author | Carullo, Nazareno Divenuto, Francesca Marascio, Nadia Adams, Neill James Giancotti, Aida Comi, Nicolino Faga, Teresa Bolignano, Davide Coppolino, Giuseppe Serapide, Francesca Costa, Chiara Torti, Carlo Matera, Giovanni Quirino, Angela Andreucci, Michele |
author_facet | Carullo, Nazareno Divenuto, Francesca Marascio, Nadia Adams, Neill James Giancotti, Aida Comi, Nicolino Faga, Teresa Bolignano, Davide Coppolino, Giuseppe Serapide, Francesca Costa, Chiara Torti, Carlo Matera, Giovanni Quirino, Angela Andreucci, Michele |
author_sort | Carullo, Nazareno |
collection | PubMed |
description | Acute interstitial nephritis (AIN) due to helminths is a rare cause of acute kidney injury (AKI). Helminthiases often progresses insidiously, making diagnosis difficult. This was the case of a 72-year-old man, who presented with renal failure, itching and diarrhoea. Urinalysis revealed leukocyturia, microhaematuria and mild proteinuria. A full blood count revealed leucocytosis with eosinophilia. A stool parasitological examination revealed fertilised eggs of Ascaris lumbricoides. Tubulointerstitial nephropathy secondary to A. lumbricoides infection was suspected. A percutaneous renal biopsy was not performed since the patient refused the anti-platelet therapy discontinuation. Mebendazole, albendazole and prednisone therapy was administered. After worm eradiation and discharge, recovery from the parasitosis, absence of pruritus and eosinophilia, and progressive improvement of renal function were observed, strongly suggesting a causal relationship between Ascaris infection and AIN. Parasite infection should be considered in the differential diagnosis of unexplained renal failure because early diagnosis and treatment are necessary to avoid irreversible complications. |
format | Online Article Text |
id | pubmed-10297354 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102973542023-06-28 A Rare Complication of Ascariasis: A Case of Acute Interstitial Nephritis Carullo, Nazareno Divenuto, Francesca Marascio, Nadia Adams, Neill James Giancotti, Aida Comi, Nicolino Faga, Teresa Bolignano, Davide Coppolino, Giuseppe Serapide, Francesca Costa, Chiara Torti, Carlo Matera, Giovanni Quirino, Angela Andreucci, Michele Diagnostics (Basel) Interesting Images Acute interstitial nephritis (AIN) due to helminths is a rare cause of acute kidney injury (AKI). Helminthiases often progresses insidiously, making diagnosis difficult. This was the case of a 72-year-old man, who presented with renal failure, itching and diarrhoea. Urinalysis revealed leukocyturia, microhaematuria and mild proteinuria. A full blood count revealed leucocytosis with eosinophilia. A stool parasitological examination revealed fertilised eggs of Ascaris lumbricoides. Tubulointerstitial nephropathy secondary to A. lumbricoides infection was suspected. A percutaneous renal biopsy was not performed since the patient refused the anti-platelet therapy discontinuation. Mebendazole, albendazole and prednisone therapy was administered. After worm eradiation and discharge, recovery from the parasitosis, absence of pruritus and eosinophilia, and progressive improvement of renal function were observed, strongly suggesting a causal relationship between Ascaris infection and AIN. Parasite infection should be considered in the differential diagnosis of unexplained renal failure because early diagnosis and treatment are necessary to avoid irreversible complications. MDPI 2023-06-14 /pmc/articles/PMC10297354/ /pubmed/37370949 http://dx.doi.org/10.3390/diagnostics13122054 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Interesting Images Carullo, Nazareno Divenuto, Francesca Marascio, Nadia Adams, Neill James Giancotti, Aida Comi, Nicolino Faga, Teresa Bolignano, Davide Coppolino, Giuseppe Serapide, Francesca Costa, Chiara Torti, Carlo Matera, Giovanni Quirino, Angela Andreucci, Michele A Rare Complication of Ascariasis: A Case of Acute Interstitial Nephritis |
title | A Rare Complication of Ascariasis: A Case of Acute Interstitial Nephritis |
title_full | A Rare Complication of Ascariasis: A Case of Acute Interstitial Nephritis |
title_fullStr | A Rare Complication of Ascariasis: A Case of Acute Interstitial Nephritis |
title_full_unstemmed | A Rare Complication of Ascariasis: A Case of Acute Interstitial Nephritis |
title_short | A Rare Complication of Ascariasis: A Case of Acute Interstitial Nephritis |
title_sort | rare complication of ascariasis: a case of acute interstitial nephritis |
topic | Interesting Images |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297354/ https://www.ncbi.nlm.nih.gov/pubmed/37370949 http://dx.doi.org/10.3390/diagnostics13122054 |
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