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A Rare Complication of Ascariasis: A Case of Acute Interstitial Nephritis

Acute interstitial nephritis (AIN) due to helminths is a rare cause of acute kidney injury (AKI). Helminthiases often progresses insidiously, making diagnosis difficult. This was the case of a 72-year-old man, who presented with renal failure, itching and diarrhoea. Urinalysis revealed leukocyturia,...

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Autores principales: Carullo, Nazareno, Divenuto, Francesca, Marascio, Nadia, Adams, Neill James, Giancotti, Aida, Comi, Nicolino, Faga, Teresa, Bolignano, Davide, Coppolino, Giuseppe, Serapide, Francesca, Costa, Chiara, Torti, Carlo, Matera, Giovanni, Quirino, Angela, Andreucci, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297354/
https://www.ncbi.nlm.nih.gov/pubmed/37370949
http://dx.doi.org/10.3390/diagnostics13122054
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author Carullo, Nazareno
Divenuto, Francesca
Marascio, Nadia
Adams, Neill James
Giancotti, Aida
Comi, Nicolino
Faga, Teresa
Bolignano, Davide
Coppolino, Giuseppe
Serapide, Francesca
Costa, Chiara
Torti, Carlo
Matera, Giovanni
Quirino, Angela
Andreucci, Michele
author_facet Carullo, Nazareno
Divenuto, Francesca
Marascio, Nadia
Adams, Neill James
Giancotti, Aida
Comi, Nicolino
Faga, Teresa
Bolignano, Davide
Coppolino, Giuseppe
Serapide, Francesca
Costa, Chiara
Torti, Carlo
Matera, Giovanni
Quirino, Angela
Andreucci, Michele
author_sort Carullo, Nazareno
collection PubMed
description Acute interstitial nephritis (AIN) due to helminths is a rare cause of acute kidney injury (AKI). Helminthiases often progresses insidiously, making diagnosis difficult. This was the case of a 72-year-old man, who presented with renal failure, itching and diarrhoea. Urinalysis revealed leukocyturia, microhaematuria and mild proteinuria. A full blood count revealed leucocytosis with eosinophilia. A stool parasitological examination revealed fertilised eggs of Ascaris lumbricoides. Tubulointerstitial nephropathy secondary to A. lumbricoides infection was suspected. A percutaneous renal biopsy was not performed since the patient refused the anti-platelet therapy discontinuation. Mebendazole, albendazole and prednisone therapy was administered. After worm eradiation and discharge, recovery from the parasitosis, absence of pruritus and eosinophilia, and progressive improvement of renal function were observed, strongly suggesting a causal relationship between Ascaris infection and AIN. Parasite infection should be considered in the differential diagnosis of unexplained renal failure because early diagnosis and treatment are necessary to avoid irreversible complications.
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spelling pubmed-102973542023-06-28 A Rare Complication of Ascariasis: A Case of Acute Interstitial Nephritis Carullo, Nazareno Divenuto, Francesca Marascio, Nadia Adams, Neill James Giancotti, Aida Comi, Nicolino Faga, Teresa Bolignano, Davide Coppolino, Giuseppe Serapide, Francesca Costa, Chiara Torti, Carlo Matera, Giovanni Quirino, Angela Andreucci, Michele Diagnostics (Basel) Interesting Images Acute interstitial nephritis (AIN) due to helminths is a rare cause of acute kidney injury (AKI). Helminthiases often progresses insidiously, making diagnosis difficult. This was the case of a 72-year-old man, who presented with renal failure, itching and diarrhoea. Urinalysis revealed leukocyturia, microhaematuria and mild proteinuria. A full blood count revealed leucocytosis with eosinophilia. A stool parasitological examination revealed fertilised eggs of Ascaris lumbricoides. Tubulointerstitial nephropathy secondary to A. lumbricoides infection was suspected. A percutaneous renal biopsy was not performed since the patient refused the anti-platelet therapy discontinuation. Mebendazole, albendazole and prednisone therapy was administered. After worm eradiation and discharge, recovery from the parasitosis, absence of pruritus and eosinophilia, and progressive improvement of renal function were observed, strongly suggesting a causal relationship between Ascaris infection and AIN. Parasite infection should be considered in the differential diagnosis of unexplained renal failure because early diagnosis and treatment are necessary to avoid irreversible complications. MDPI 2023-06-14 /pmc/articles/PMC10297354/ /pubmed/37370949 http://dx.doi.org/10.3390/diagnostics13122054 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Interesting Images
Carullo, Nazareno
Divenuto, Francesca
Marascio, Nadia
Adams, Neill James
Giancotti, Aida
Comi, Nicolino
Faga, Teresa
Bolignano, Davide
Coppolino, Giuseppe
Serapide, Francesca
Costa, Chiara
Torti, Carlo
Matera, Giovanni
Quirino, Angela
Andreucci, Michele
A Rare Complication of Ascariasis: A Case of Acute Interstitial Nephritis
title A Rare Complication of Ascariasis: A Case of Acute Interstitial Nephritis
title_full A Rare Complication of Ascariasis: A Case of Acute Interstitial Nephritis
title_fullStr A Rare Complication of Ascariasis: A Case of Acute Interstitial Nephritis
title_full_unstemmed A Rare Complication of Ascariasis: A Case of Acute Interstitial Nephritis
title_short A Rare Complication of Ascariasis: A Case of Acute Interstitial Nephritis
title_sort rare complication of ascariasis: a case of acute interstitial nephritis
topic Interesting Images
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297354/
https://www.ncbi.nlm.nih.gov/pubmed/37370949
http://dx.doi.org/10.3390/diagnostics13122054
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