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The Biologist’s Guide to the Glucocorticoid Receptor’s Structure
The glucocorticoid receptor α (GRα) is a member of the nuclear receptor superfamily and functions as a glucocorticoid (GC)-responsive transcription factor. GR can halt inflammation and kill off cancer cells, thus explaining the widespread use of glucocorticoids in the clinic. However, side effects a...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297449/ https://www.ncbi.nlm.nih.gov/pubmed/37371105 http://dx.doi.org/10.3390/cells12121636 |
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author | Deploey, Nick Van Moortel, Laura Rogatsky, Inez Peelman, Frank De Bosscher, Karolien |
author_facet | Deploey, Nick Van Moortel, Laura Rogatsky, Inez Peelman, Frank De Bosscher, Karolien |
author_sort | Deploey, Nick |
collection | PubMed |
description | The glucocorticoid receptor α (GRα) is a member of the nuclear receptor superfamily and functions as a glucocorticoid (GC)-responsive transcription factor. GR can halt inflammation and kill off cancer cells, thus explaining the widespread use of glucocorticoids in the clinic. However, side effects and therapy resistance limit GR’s therapeutic potential, emphasizing the importance of resolving all of GR’s context-specific action mechanisms. Fortunately, the understanding of GR structure, conformation, and stoichiometry in the different GR-controlled biological pathways is now gradually increasing. This information will be crucial to close knowledge gaps on GR function. In this review, we focus on the various domains and mechanisms of action of GR, all from a structural perspective. |
format | Online Article Text |
id | pubmed-10297449 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102974492023-06-28 The Biologist’s Guide to the Glucocorticoid Receptor’s Structure Deploey, Nick Van Moortel, Laura Rogatsky, Inez Peelman, Frank De Bosscher, Karolien Cells Review The glucocorticoid receptor α (GRα) is a member of the nuclear receptor superfamily and functions as a glucocorticoid (GC)-responsive transcription factor. GR can halt inflammation and kill off cancer cells, thus explaining the widespread use of glucocorticoids in the clinic. However, side effects and therapy resistance limit GR’s therapeutic potential, emphasizing the importance of resolving all of GR’s context-specific action mechanisms. Fortunately, the understanding of GR structure, conformation, and stoichiometry in the different GR-controlled biological pathways is now gradually increasing. This information will be crucial to close knowledge gaps on GR function. In this review, we focus on the various domains and mechanisms of action of GR, all from a structural perspective. MDPI 2023-06-15 /pmc/articles/PMC10297449/ /pubmed/37371105 http://dx.doi.org/10.3390/cells12121636 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Deploey, Nick Van Moortel, Laura Rogatsky, Inez Peelman, Frank De Bosscher, Karolien The Biologist’s Guide to the Glucocorticoid Receptor’s Structure |
title | The Biologist’s Guide to the Glucocorticoid Receptor’s Structure |
title_full | The Biologist’s Guide to the Glucocorticoid Receptor’s Structure |
title_fullStr | The Biologist’s Guide to the Glucocorticoid Receptor’s Structure |
title_full_unstemmed | The Biologist’s Guide to the Glucocorticoid Receptor’s Structure |
title_short | The Biologist’s Guide to the Glucocorticoid Receptor’s Structure |
title_sort | biologist’s guide to the glucocorticoid receptor’s structure |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297449/ https://www.ncbi.nlm.nih.gov/pubmed/37371105 http://dx.doi.org/10.3390/cells12121636 |
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