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The Biologist’s Guide to the Glucocorticoid Receptor’s Structure

The glucocorticoid receptor α (GRα) is a member of the nuclear receptor superfamily and functions as a glucocorticoid (GC)-responsive transcription factor. GR can halt inflammation and kill off cancer cells, thus explaining the widespread use of glucocorticoids in the clinic. However, side effects a...

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Autores principales: Deploey, Nick, Van Moortel, Laura, Rogatsky, Inez, Peelman, Frank, De Bosscher, Karolien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297449/
https://www.ncbi.nlm.nih.gov/pubmed/37371105
http://dx.doi.org/10.3390/cells12121636
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author Deploey, Nick
Van Moortel, Laura
Rogatsky, Inez
Peelman, Frank
De Bosscher, Karolien
author_facet Deploey, Nick
Van Moortel, Laura
Rogatsky, Inez
Peelman, Frank
De Bosscher, Karolien
author_sort Deploey, Nick
collection PubMed
description The glucocorticoid receptor α (GRα) is a member of the nuclear receptor superfamily and functions as a glucocorticoid (GC)-responsive transcription factor. GR can halt inflammation and kill off cancer cells, thus explaining the widespread use of glucocorticoids in the clinic. However, side effects and therapy resistance limit GR’s therapeutic potential, emphasizing the importance of resolving all of GR’s context-specific action mechanisms. Fortunately, the understanding of GR structure, conformation, and stoichiometry in the different GR-controlled biological pathways is now gradually increasing. This information will be crucial to close knowledge gaps on GR function. In this review, we focus on the various domains and mechanisms of action of GR, all from a structural perspective.
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spelling pubmed-102974492023-06-28 The Biologist’s Guide to the Glucocorticoid Receptor’s Structure Deploey, Nick Van Moortel, Laura Rogatsky, Inez Peelman, Frank De Bosscher, Karolien Cells Review The glucocorticoid receptor α (GRα) is a member of the nuclear receptor superfamily and functions as a glucocorticoid (GC)-responsive transcription factor. GR can halt inflammation and kill off cancer cells, thus explaining the widespread use of glucocorticoids in the clinic. However, side effects and therapy resistance limit GR’s therapeutic potential, emphasizing the importance of resolving all of GR’s context-specific action mechanisms. Fortunately, the understanding of GR structure, conformation, and stoichiometry in the different GR-controlled biological pathways is now gradually increasing. This information will be crucial to close knowledge gaps on GR function. In this review, we focus on the various domains and mechanisms of action of GR, all from a structural perspective. MDPI 2023-06-15 /pmc/articles/PMC10297449/ /pubmed/37371105 http://dx.doi.org/10.3390/cells12121636 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Deploey, Nick
Van Moortel, Laura
Rogatsky, Inez
Peelman, Frank
De Bosscher, Karolien
The Biologist’s Guide to the Glucocorticoid Receptor’s Structure
title The Biologist’s Guide to the Glucocorticoid Receptor’s Structure
title_full The Biologist’s Guide to the Glucocorticoid Receptor’s Structure
title_fullStr The Biologist’s Guide to the Glucocorticoid Receptor’s Structure
title_full_unstemmed The Biologist’s Guide to the Glucocorticoid Receptor’s Structure
title_short The Biologist’s Guide to the Glucocorticoid Receptor’s Structure
title_sort biologist’s guide to the glucocorticoid receptor’s structure
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297449/
https://www.ncbi.nlm.nih.gov/pubmed/37371105
http://dx.doi.org/10.3390/cells12121636
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