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Neurodevelopmental Outcome at 6 Months Following Neonatal Resuscitation in Rural Tanzania
Early bag-mask ventilation (BMV) administered to non-breathing neonates at birth in the presence of birth asphyxia (interruption of placental blood flow) has reduced neonatal mortality by up to 50% in low- and middle-income countries. The neurodevelopmental outcome of neonates receiving BMV remains...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297458/ https://www.ncbi.nlm.nih.gov/pubmed/37371189 http://dx.doi.org/10.3390/children10060957 |
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author | Torvik, Ingrid Ask Moshiro, Robert Ersdal, Hege Yeconia, Anita Mduma, Raphael Perlman, Jeffrey Linde, Jørgen |
author_facet | Torvik, Ingrid Ask Moshiro, Robert Ersdal, Hege Yeconia, Anita Mduma, Raphael Perlman, Jeffrey Linde, Jørgen |
author_sort | Torvik, Ingrid Ask |
collection | PubMed |
description | Early bag-mask ventilation (BMV) administered to non-breathing neonates at birth in the presence of birth asphyxia (interruption of placental blood flow) has reduced neonatal mortality by up to 50% in low- and middle-income countries. The neurodevelopmental outcome of neonates receiving BMV remains unknown. Using the Malawi Developmental Assessment Tool (MDAT), infants who received BMV at birth were assessed at 6 months, evaluating gross motor, fine motor, language and social skills. A healthy cohort with no birth complications was assessed with the same tool for comparison. Mean age-adjusted MDAT z-scores were not significantly different between the groups. The number of children having developmental delay defined as a z-score ≤ −2 was significantly higher in the resuscitated cohort for the fine motor and language domain and overall MDAT z-score. The prevalence of clinical seizures post discharge was significantly higher in the resuscitated group and was associated with neurodevelopmental delay. Infants with developmental delay or seizures were more likely to have a 5 min Apgar < 7 and a longer duration of BMV. Most children receiving BMV at birth are developing normally at 6 months. Still, there are some children with impaired development among resuscitated children, representing a subgroup of children who may have suffered more severe asphyxia. |
format | Online Article Text |
id | pubmed-10297458 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102974582023-06-28 Neurodevelopmental Outcome at 6 Months Following Neonatal Resuscitation in Rural Tanzania Torvik, Ingrid Ask Moshiro, Robert Ersdal, Hege Yeconia, Anita Mduma, Raphael Perlman, Jeffrey Linde, Jørgen Children (Basel) Article Early bag-mask ventilation (BMV) administered to non-breathing neonates at birth in the presence of birth asphyxia (interruption of placental blood flow) has reduced neonatal mortality by up to 50% in low- and middle-income countries. The neurodevelopmental outcome of neonates receiving BMV remains unknown. Using the Malawi Developmental Assessment Tool (MDAT), infants who received BMV at birth were assessed at 6 months, evaluating gross motor, fine motor, language and social skills. A healthy cohort with no birth complications was assessed with the same tool for comparison. Mean age-adjusted MDAT z-scores were not significantly different between the groups. The number of children having developmental delay defined as a z-score ≤ −2 was significantly higher in the resuscitated cohort for the fine motor and language domain and overall MDAT z-score. The prevalence of clinical seizures post discharge was significantly higher in the resuscitated group and was associated with neurodevelopmental delay. Infants with developmental delay or seizures were more likely to have a 5 min Apgar < 7 and a longer duration of BMV. Most children receiving BMV at birth are developing normally at 6 months. Still, there are some children with impaired development among resuscitated children, representing a subgroup of children who may have suffered more severe asphyxia. MDPI 2023-05-27 /pmc/articles/PMC10297458/ /pubmed/37371189 http://dx.doi.org/10.3390/children10060957 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Torvik, Ingrid Ask Moshiro, Robert Ersdal, Hege Yeconia, Anita Mduma, Raphael Perlman, Jeffrey Linde, Jørgen Neurodevelopmental Outcome at 6 Months Following Neonatal Resuscitation in Rural Tanzania |
title | Neurodevelopmental Outcome at 6 Months Following Neonatal Resuscitation in Rural Tanzania |
title_full | Neurodevelopmental Outcome at 6 Months Following Neonatal Resuscitation in Rural Tanzania |
title_fullStr | Neurodevelopmental Outcome at 6 Months Following Neonatal Resuscitation in Rural Tanzania |
title_full_unstemmed | Neurodevelopmental Outcome at 6 Months Following Neonatal Resuscitation in Rural Tanzania |
title_short | Neurodevelopmental Outcome at 6 Months Following Neonatal Resuscitation in Rural Tanzania |
title_sort | neurodevelopmental outcome at 6 months following neonatal resuscitation in rural tanzania |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297458/ https://www.ncbi.nlm.nih.gov/pubmed/37371189 http://dx.doi.org/10.3390/children10060957 |
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