Circadian Disruption Primes Myofibroblasts for Accelerated Activation as a Mechanism Underpinning Fibrotic Progression in Non-Alcoholic Fatty Liver Disease

Circadian rhythm governs many aspects of liver physiology and its disruption exacerbates chronic disease. CLOCKΔ19 mice disrupted circadian rhythm and spontaneously developed obesity and metabolic syndrome, a phenotype that parallels the progression of non-alcoholic fatty liver disease (NAFLD). NAFL...

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Detalles Bibliográficos
Autores principales: Jokl, Elliot, Llewellyn, Jessica, Simpson, Kara, Adegboye, Oluwatobi, Pritchett, James, Zeef, Leo, Donaldson, Ian, Athwal, Varinder S., Purssell, Huw, Street, Oliver, Bennett, Lucy, Guha, Indra Neil, Hanley, Neil A., Meng, Qing-Jun, Piper Hanley, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297459/
https://www.ncbi.nlm.nih.gov/pubmed/37371052
http://dx.doi.org/10.3390/cells12121582

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