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The Role of Mesenchymal Stromal Cells and Their Products in the Treatment of Injured Spinal Cords
Spinal cord injury (SCI) is a destructive condition that results in lasting neurological damage resulting in disruption of the connection between the central nervous system and the rest of the body. Currently, there are several approaches in the treatment of a damaged spinal cord; however, none of t...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297479/ https://www.ncbi.nlm.nih.gov/pubmed/37367078 http://dx.doi.org/10.3390/cimb45060329 |
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author | Slovinska, Lucia Harvanova, Denisa |
author_facet | Slovinska, Lucia Harvanova, Denisa |
author_sort | Slovinska, Lucia |
collection | PubMed |
description | Spinal cord injury (SCI) is a destructive condition that results in lasting neurological damage resulting in disruption of the connection between the central nervous system and the rest of the body. Currently, there are several approaches in the treatment of a damaged spinal cord; however, none of the methods allow the patient to return to the original full-featured state of life before the injury. Cell transplantation therapies show great potential in the treatment of damaged spinal cords. The most examined type of cells used in SCI research are mesenchymal stromal cells (MSCs). These cells are at the center of interest of scientists because of their unique properties. MSCs regenerate the injured tissue in two ways: (i) they are able to differentiate into some types of cells and so can replace the cells of injured tissue and (ii) they regenerate tissue through their powerful known paracrine effect. This review presents information about SCI and the treatments usually used, aiming at cell therapy using MSCs and their products, among which active biomolecules and extracellular vesicles predominate. |
format | Online Article Text |
id | pubmed-10297479 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102974792023-06-28 The Role of Mesenchymal Stromal Cells and Their Products in the Treatment of Injured Spinal Cords Slovinska, Lucia Harvanova, Denisa Curr Issues Mol Biol Review Spinal cord injury (SCI) is a destructive condition that results in lasting neurological damage resulting in disruption of the connection between the central nervous system and the rest of the body. Currently, there are several approaches in the treatment of a damaged spinal cord; however, none of the methods allow the patient to return to the original full-featured state of life before the injury. Cell transplantation therapies show great potential in the treatment of damaged spinal cords. The most examined type of cells used in SCI research are mesenchymal stromal cells (MSCs). These cells are at the center of interest of scientists because of their unique properties. MSCs regenerate the injured tissue in two ways: (i) they are able to differentiate into some types of cells and so can replace the cells of injured tissue and (ii) they regenerate tissue through their powerful known paracrine effect. This review presents information about SCI and the treatments usually used, aiming at cell therapy using MSCs and their products, among which active biomolecules and extracellular vesicles predominate. MDPI 2023-06-16 /pmc/articles/PMC10297479/ /pubmed/37367078 http://dx.doi.org/10.3390/cimb45060329 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Slovinska, Lucia Harvanova, Denisa The Role of Mesenchymal Stromal Cells and Their Products in the Treatment of Injured Spinal Cords |
title | The Role of Mesenchymal Stromal Cells and Their Products in the Treatment of Injured Spinal Cords |
title_full | The Role of Mesenchymal Stromal Cells and Their Products in the Treatment of Injured Spinal Cords |
title_fullStr | The Role of Mesenchymal Stromal Cells and Their Products in the Treatment of Injured Spinal Cords |
title_full_unstemmed | The Role of Mesenchymal Stromal Cells and Their Products in the Treatment of Injured Spinal Cords |
title_short | The Role of Mesenchymal Stromal Cells and Their Products in the Treatment of Injured Spinal Cords |
title_sort | role of mesenchymal stromal cells and their products in the treatment of injured spinal cords |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297479/ https://www.ncbi.nlm.nih.gov/pubmed/37367078 http://dx.doi.org/10.3390/cimb45060329 |
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