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Adenovirus as a Vector and Oncolytic Virus

Adenoviral vectors, both oncolytic viruses and gene delivery vectors, are among the earliest approved and commercialised vectors for gene therapy. Adenoviruses have high cytotoxicity and immunogenicity. Therefore, lentiviruses or adeno-associated viruses as viral vectors and herpes simplex virus as...

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Autores principales: Matsunaga, Wataru, Gotoh, Akinobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297569/
https://www.ncbi.nlm.nih.gov/pubmed/37367056
http://dx.doi.org/10.3390/cimb45060307
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author Matsunaga, Wataru
Gotoh, Akinobu
author_facet Matsunaga, Wataru
Gotoh, Akinobu
author_sort Matsunaga, Wataru
collection PubMed
description Adenoviral vectors, both oncolytic viruses and gene delivery vectors, are among the earliest approved and commercialised vectors for gene therapy. Adenoviruses have high cytotoxicity and immunogenicity. Therefore, lentiviruses or adeno-associated viruses as viral vectors and herpes simplex virus as an oncolytic virus have recently drawn attention. Thus, adenoviral vectors are often considered relatively obsolete. However, their high cargo limit and transduction efficiency are significant advantages over newer viral vectors. This review provides an overview of the new-generation adenoviral vectors. In addition, we describe the modification of the fiber knob region that enhances affinity of adenoviral vectors for cancer cells and the utilisation of cancer-cell-specific promoters to suppress expression of unwanted transgenes in non-malignant tissues.
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spelling pubmed-102975692023-06-28 Adenovirus as a Vector and Oncolytic Virus Matsunaga, Wataru Gotoh, Akinobu Curr Issues Mol Biol Review Adenoviral vectors, both oncolytic viruses and gene delivery vectors, are among the earliest approved and commercialised vectors for gene therapy. Adenoviruses have high cytotoxicity and immunogenicity. Therefore, lentiviruses or adeno-associated viruses as viral vectors and herpes simplex virus as an oncolytic virus have recently drawn attention. Thus, adenoviral vectors are often considered relatively obsolete. However, their high cargo limit and transduction efficiency are significant advantages over newer viral vectors. This review provides an overview of the new-generation adenoviral vectors. In addition, we describe the modification of the fiber knob region that enhances affinity of adenoviral vectors for cancer cells and the utilisation of cancer-cell-specific promoters to suppress expression of unwanted transgenes in non-malignant tissues. MDPI 2023-06-02 /pmc/articles/PMC10297569/ /pubmed/37367056 http://dx.doi.org/10.3390/cimb45060307 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Matsunaga, Wataru
Gotoh, Akinobu
Adenovirus as a Vector and Oncolytic Virus
title Adenovirus as a Vector and Oncolytic Virus
title_full Adenovirus as a Vector and Oncolytic Virus
title_fullStr Adenovirus as a Vector and Oncolytic Virus
title_full_unstemmed Adenovirus as a Vector and Oncolytic Virus
title_short Adenovirus as a Vector and Oncolytic Virus
title_sort adenovirus as a vector and oncolytic virus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297569/
https://www.ncbi.nlm.nih.gov/pubmed/37367056
http://dx.doi.org/10.3390/cimb45060307
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