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Esophagogastroduodenal Findings in Patients with Intraductal Papillary Mucinous Neoplasms

The association between intraductal papillary mucinous neoplasms (IPMNs) and extra-pancreatic malignancies is controversial. This cross-sectional study compared esophagogastroduodenal findings in 340 IPMN patients to those of age- and gender-matched controls without known IPMNs who underwent esophag...

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Autores principales: Zelnik Yovel, Dana, Santo, Erwin, Khader, Majd, Tzadok, Roie, Bar, Nir, Aizic, Asaf, Shibolet, Oren, Ben-Ami Shor, Dana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297689/
https://www.ncbi.nlm.nih.gov/pubmed/37371022
http://dx.doi.org/10.3390/diagnostics13122127
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author Zelnik Yovel, Dana
Santo, Erwin
Khader, Majd
Tzadok, Roie
Bar, Nir
Aizic, Asaf
Shibolet, Oren
Ben-Ami Shor, Dana
author_facet Zelnik Yovel, Dana
Santo, Erwin
Khader, Majd
Tzadok, Roie
Bar, Nir
Aizic, Asaf
Shibolet, Oren
Ben-Ami Shor, Dana
author_sort Zelnik Yovel, Dana
collection PubMed
description The association between intraductal papillary mucinous neoplasms (IPMNs) and extra-pancreatic malignancies is controversial. This cross-sectional study compared esophagogastroduodenal findings in 340 IPMN patients to those of age- and gender-matched controls without known IPMNs who underwent esophagogastroduodenoscopies (EGDs) for similar clinical reasons. The presence of gastric and esophageal cancer, Barrett’s esophagus, neuroendocrine tumors (NETs), gastrointestinal stromal tumors (GISTs), gastric adenomas, and ampullary tumors was assessed. The results showed that 4/340 (1.2%) of the IPMN patients had gastric cancer and 1/340 (0.3%) had esophageal cancer. The matched control group had a similar incidence of gastric cancer (5/340) (1.5%), with no esophageal cancer cases (p > 0.999). The overall incidence of other esophagogastroduodenal conditions did not significantly differ between the IPMN patients and the controls. However, the incidence of gastric cancer in the IPMN patients was higher than expected based on national cancer registry data (standardized incidence ratio of 31.39; p < 0.001; CI 8.38–78.76). In conclusion, IPMN patients have a significantly higher incidence of gastric cancer compared to the general population. However, the incidence of esophagogastroduodenal findings, including gastric and esophageal cancer, is similar between IPMN patients and those who undergo an EGD for similar clinical indications. Further research is needed to determine optimal surveillance strategies for IPMN patients regarding their risk of developing gastric cancer.
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spelling pubmed-102976892023-06-28 Esophagogastroduodenal Findings in Patients with Intraductal Papillary Mucinous Neoplasms Zelnik Yovel, Dana Santo, Erwin Khader, Majd Tzadok, Roie Bar, Nir Aizic, Asaf Shibolet, Oren Ben-Ami Shor, Dana Diagnostics (Basel) Article The association between intraductal papillary mucinous neoplasms (IPMNs) and extra-pancreatic malignancies is controversial. This cross-sectional study compared esophagogastroduodenal findings in 340 IPMN patients to those of age- and gender-matched controls without known IPMNs who underwent esophagogastroduodenoscopies (EGDs) for similar clinical reasons. The presence of gastric and esophageal cancer, Barrett’s esophagus, neuroendocrine tumors (NETs), gastrointestinal stromal tumors (GISTs), gastric adenomas, and ampullary tumors was assessed. The results showed that 4/340 (1.2%) of the IPMN patients had gastric cancer and 1/340 (0.3%) had esophageal cancer. The matched control group had a similar incidence of gastric cancer (5/340) (1.5%), with no esophageal cancer cases (p > 0.999). The overall incidence of other esophagogastroduodenal conditions did not significantly differ between the IPMN patients and the controls. However, the incidence of gastric cancer in the IPMN patients was higher than expected based on national cancer registry data (standardized incidence ratio of 31.39; p < 0.001; CI 8.38–78.76). In conclusion, IPMN patients have a significantly higher incidence of gastric cancer compared to the general population. However, the incidence of esophagogastroduodenal findings, including gastric and esophageal cancer, is similar between IPMN patients and those who undergo an EGD for similar clinical indications. Further research is needed to determine optimal surveillance strategies for IPMN patients regarding their risk of developing gastric cancer. MDPI 2023-06-20 /pmc/articles/PMC10297689/ /pubmed/37371022 http://dx.doi.org/10.3390/diagnostics13122127 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zelnik Yovel, Dana
Santo, Erwin
Khader, Majd
Tzadok, Roie
Bar, Nir
Aizic, Asaf
Shibolet, Oren
Ben-Ami Shor, Dana
Esophagogastroduodenal Findings in Patients with Intraductal Papillary Mucinous Neoplasms
title Esophagogastroduodenal Findings in Patients with Intraductal Papillary Mucinous Neoplasms
title_full Esophagogastroduodenal Findings in Patients with Intraductal Papillary Mucinous Neoplasms
title_fullStr Esophagogastroduodenal Findings in Patients with Intraductal Papillary Mucinous Neoplasms
title_full_unstemmed Esophagogastroduodenal Findings in Patients with Intraductal Papillary Mucinous Neoplasms
title_short Esophagogastroduodenal Findings in Patients with Intraductal Papillary Mucinous Neoplasms
title_sort esophagogastroduodenal findings in patients with intraductal papillary mucinous neoplasms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297689/
https://www.ncbi.nlm.nih.gov/pubmed/37371022
http://dx.doi.org/10.3390/diagnostics13122127
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