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The VA-CAL Test Quantifies Improvement of Visual Acuity in Achromatopsia by Means of Short-Wave Cutoff Filter Glasses in Daily Living Conditions

PURPOSE: To quantify visual performance of patients with achromatopsia at various contrast and luminance combinations typical for daily living conditions, in comparison to controls, and to measure beneficial effects of short-wavelength cutoff filter glasses used by patients with achromatopsia to red...

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Autores principales: Hilmers, Julian, Bach, Michael, Stingl, Katarina, Zrenner, Eberhart, Straßer, Torsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297778/
https://www.ncbi.nlm.nih.gov/pubmed/37358491
http://dx.doi.org/10.1167/tvst.12.6.20
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author Hilmers, Julian
Bach, Michael
Stingl, Katarina
Zrenner, Eberhart
Straßer, Torsten
author_facet Hilmers, Julian
Bach, Michael
Stingl, Katarina
Zrenner, Eberhart
Straßer, Torsten
author_sort Hilmers, Julian
collection PubMed
description PURPOSE: To quantify visual performance of patients with achromatopsia at various contrast and luminance combinations typical for daily living conditions, in comparison to controls, and to measure beneficial effects of short-wavelength cutoff filter glasses used by patients with achromatopsia to reduce glare sensation. METHODS: Best-corrected visual acuity (BCVA) was tested with Landolt rings using an automated device (VA-CAL test). The visual acuity space was assessed for each participant with and without filter glasses (transmission >550 nm) at 46 contrast–luminance combinations (18%–95%; 0–10,000 cd/m(2)). The BCVA differences between both conditions were calculated for each combination as absolute values and relative to individual standard BCVA. RESULTS: Fourteen achromats (mean ± SD: 37.9 ± 17.6 years) and 14 normally sighted controls (mean ± SD: 25.2 ± 2.8 years) were included in the study. Without filter glasses, achromats’ BCVA was best at 30 cd/m(2) (mean ± SEM: 0.76 ± 0.046 logarithm of the minimum angle of resolution [logMAR], contrast = 89%) and worst at 10,000 cd/m(2) (mean ± SEM: 1.41 ± 0.08 logMAR, contrast = 18%), a deterioration up to 0.6 logMAR due to increased luminance and decreased contrast. Filter glasses improved achromats’ BCVA for almost all luminances by about 0.2 logMAR but lowered controls’ BCVA by about 0.1 logMAR. CONCLUSIONS: The VA-CAL test provides numerical proof that short-wavelength cutoff filter glasses can help patients with achromatopsia in everyday life, avoiding the common situation of severe visual impairment at certain daily object contrasts and ambient luminances. TRANSLATIONAL RELEVANCE: The VA-CAL test discovers losses of spatial resolution in the visual acuity space not seen in standardized BCVA assessment. Filter glasses improve the patients’ daily visual performance, rendering them a strongly recommended visual aid in achromatopsia.
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spelling pubmed-102977782023-06-28 The VA-CAL Test Quantifies Improvement of Visual Acuity in Achromatopsia by Means of Short-Wave Cutoff Filter Glasses in Daily Living Conditions Hilmers, Julian Bach, Michael Stingl, Katarina Zrenner, Eberhart Straßer, Torsten Transl Vis Sci Technol Low Vision Rehabilitation PURPOSE: To quantify visual performance of patients with achromatopsia at various contrast and luminance combinations typical for daily living conditions, in comparison to controls, and to measure beneficial effects of short-wavelength cutoff filter glasses used by patients with achromatopsia to reduce glare sensation. METHODS: Best-corrected visual acuity (BCVA) was tested with Landolt rings using an automated device (VA-CAL test). The visual acuity space was assessed for each participant with and without filter glasses (transmission >550 nm) at 46 contrast–luminance combinations (18%–95%; 0–10,000 cd/m(2)). The BCVA differences between both conditions were calculated for each combination as absolute values and relative to individual standard BCVA. RESULTS: Fourteen achromats (mean ± SD: 37.9 ± 17.6 years) and 14 normally sighted controls (mean ± SD: 25.2 ± 2.8 years) were included in the study. Without filter glasses, achromats’ BCVA was best at 30 cd/m(2) (mean ± SEM: 0.76 ± 0.046 logarithm of the minimum angle of resolution [logMAR], contrast = 89%) and worst at 10,000 cd/m(2) (mean ± SEM: 1.41 ± 0.08 logMAR, contrast = 18%), a deterioration up to 0.6 logMAR due to increased luminance and decreased contrast. Filter glasses improved achromats’ BCVA for almost all luminances by about 0.2 logMAR but lowered controls’ BCVA by about 0.1 logMAR. CONCLUSIONS: The VA-CAL test provides numerical proof that short-wavelength cutoff filter glasses can help patients with achromatopsia in everyday life, avoiding the common situation of severe visual impairment at certain daily object contrasts and ambient luminances. TRANSLATIONAL RELEVANCE: The VA-CAL test discovers losses of spatial resolution in the visual acuity space not seen in standardized BCVA assessment. Filter glasses improve the patients’ daily visual performance, rendering them a strongly recommended visual aid in achromatopsia. The Association for Research in Vision and Ophthalmology 2023-06-26 /pmc/articles/PMC10297778/ /pubmed/37358491 http://dx.doi.org/10.1167/tvst.12.6.20 Text en Copyright 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Low Vision Rehabilitation
Hilmers, Julian
Bach, Michael
Stingl, Katarina
Zrenner, Eberhart
Straßer, Torsten
The VA-CAL Test Quantifies Improvement of Visual Acuity in Achromatopsia by Means of Short-Wave Cutoff Filter Glasses in Daily Living Conditions
title The VA-CAL Test Quantifies Improvement of Visual Acuity in Achromatopsia by Means of Short-Wave Cutoff Filter Glasses in Daily Living Conditions
title_full The VA-CAL Test Quantifies Improvement of Visual Acuity in Achromatopsia by Means of Short-Wave Cutoff Filter Glasses in Daily Living Conditions
title_fullStr The VA-CAL Test Quantifies Improvement of Visual Acuity in Achromatopsia by Means of Short-Wave Cutoff Filter Glasses in Daily Living Conditions
title_full_unstemmed The VA-CAL Test Quantifies Improvement of Visual Acuity in Achromatopsia by Means of Short-Wave Cutoff Filter Glasses in Daily Living Conditions
title_short The VA-CAL Test Quantifies Improvement of Visual Acuity in Achromatopsia by Means of Short-Wave Cutoff Filter Glasses in Daily Living Conditions
title_sort va-cal test quantifies improvement of visual acuity in achromatopsia by means of short-wave cutoff filter glasses in daily living conditions
topic Low Vision Rehabilitation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297778/
https://www.ncbi.nlm.nih.gov/pubmed/37358491
http://dx.doi.org/10.1167/tvst.12.6.20
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