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Inflammatory Bowel Disease: Crosstalk between Histamine, Immunity, and Disease
Inflammatory bowel disease (IBD) is increasingly recognized as a serious, worldwide public health concern. It is generally acknowledged that a variety of factors play a role in the pathogenesis of this group of chronic inflammatory diseases. The diversity of molecular actors involved in IBD does not...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297875/ https://www.ncbi.nlm.nih.gov/pubmed/37373085 http://dx.doi.org/10.3390/ijms24129937 |
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author | Dvornikova, Kristina A. Platonova, Olga N. Bystrova, Elena Y. |
author_facet | Dvornikova, Kristina A. Platonova, Olga N. Bystrova, Elena Y. |
author_sort | Dvornikova, Kristina A. |
collection | PubMed |
description | Inflammatory bowel disease (IBD) is increasingly recognized as a serious, worldwide public health concern. It is generally acknowledged that a variety of factors play a role in the pathogenesis of this group of chronic inflammatory diseases. The diversity of molecular actors involved in IBD does not allow us to fully assess the causal relationships existing in such interactions. Given the high immunomodulatory activity of histamine and the complex immune-mediated nature of inflammatory bowel disease, the role of histamine and its receptors in the gut may be significant. This paper has been prepared to provide a schematic of the most important and possible molecular signaling pathways related to histamine and its receptors and to assess their relevance for the development of therapeutic approaches. |
format | Online Article Text |
id | pubmed-10297875 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102978752023-06-28 Inflammatory Bowel Disease: Crosstalk between Histamine, Immunity, and Disease Dvornikova, Kristina A. Platonova, Olga N. Bystrova, Elena Y. Int J Mol Sci Review Inflammatory bowel disease (IBD) is increasingly recognized as a serious, worldwide public health concern. It is generally acknowledged that a variety of factors play a role in the pathogenesis of this group of chronic inflammatory diseases. The diversity of molecular actors involved in IBD does not allow us to fully assess the causal relationships existing in such interactions. Given the high immunomodulatory activity of histamine and the complex immune-mediated nature of inflammatory bowel disease, the role of histamine and its receptors in the gut may be significant. This paper has been prepared to provide a schematic of the most important and possible molecular signaling pathways related to histamine and its receptors and to assess their relevance for the development of therapeutic approaches. MDPI 2023-06-09 /pmc/articles/PMC10297875/ /pubmed/37373085 http://dx.doi.org/10.3390/ijms24129937 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dvornikova, Kristina A. Platonova, Olga N. Bystrova, Elena Y. Inflammatory Bowel Disease: Crosstalk between Histamine, Immunity, and Disease |
title | Inflammatory Bowel Disease: Crosstalk between Histamine, Immunity, and Disease |
title_full | Inflammatory Bowel Disease: Crosstalk between Histamine, Immunity, and Disease |
title_fullStr | Inflammatory Bowel Disease: Crosstalk between Histamine, Immunity, and Disease |
title_full_unstemmed | Inflammatory Bowel Disease: Crosstalk between Histamine, Immunity, and Disease |
title_short | Inflammatory Bowel Disease: Crosstalk between Histamine, Immunity, and Disease |
title_sort | inflammatory bowel disease: crosstalk between histamine, immunity, and disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297875/ https://www.ncbi.nlm.nih.gov/pubmed/37373085 http://dx.doi.org/10.3390/ijms24129937 |
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