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Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells

TRIM28/KAP1/TIF1β is a crucial epigenetic modifier. Genetic ablation of trim28 is embryonic lethal, although RNAi-mediated knockdown in somatic cells yields viable cells. Reduction in TRIM28 abundance at the cellular or organismal level results in polyphenism. Posttranslational modifications such as...

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Detalles Bibliográficos
Autores principales:	Chang, Yao-Jen, Lin, Steven, Kang, Zhi-Fu, Shen, Bin-Jon, Tsai, Wen-Hai, Chen, Wen-Ching, Lu, Hsin-Pin, Su, Yu-Lun, Chou, Shu-Jen, Lin, Shu-Yu, Lin, Sheng-Wei, Huang, Yin-Jung, Wang, Hsin-Hui, Chang, Ching-Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298087/ https://www.ncbi.nlm.nih.gov/pubmed/37372979 http://dx.doi.org/10.3390/ijms24129830

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