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The Brain Pre-Metastatic Niche: Biological and Technical Advancements
Metastasis, particularly brain metastasis, continues to puzzle researchers to this day, and exploring its molecular basis promises to break ground in developing new strategies for combatting this deadly cancer. In recent years, the research focus has shifted toward the earliest steps in the formatio...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298140/ https://www.ncbi.nlm.nih.gov/pubmed/37373202 http://dx.doi.org/10.3390/ijms241210055 |
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author | Geissler, Maximilian Jia, Weiyi Kiraz, Emine Nisanur Kulacz, Ida Liu, Xiao Rombach, Adrian Prinz, Vincent Jussen, Daniel Kokkaliaris, Konstantinos D. Medyouf, Hind Sevenich, Lisa Czabanka, Marcus Broggini, Thomas |
author_facet | Geissler, Maximilian Jia, Weiyi Kiraz, Emine Nisanur Kulacz, Ida Liu, Xiao Rombach, Adrian Prinz, Vincent Jussen, Daniel Kokkaliaris, Konstantinos D. Medyouf, Hind Sevenich, Lisa Czabanka, Marcus Broggini, Thomas |
author_sort | Geissler, Maximilian |
collection | PubMed |
description | Metastasis, particularly brain metastasis, continues to puzzle researchers to this day, and exploring its molecular basis promises to break ground in developing new strategies for combatting this deadly cancer. In recent years, the research focus has shifted toward the earliest steps in the formation of metastasis. In this regard, significant progress has been achieved in understanding how the primary tumor affects distant organ sites before the arrival of tumor cells. The term pre-metastatic niche was introduced for this concept and encompasses all influences on sites of future metastases, ranging from immunological modulation and ECM remodeling to the softening of the blood–brain barrier. The mechanisms governing the spread of metastasis to the brain remain elusive. However, we begin to understand these processes by looking at the earliest steps in the formation of metastasis. This review aims to present recent findings on the brain pre-metastatic niche and to discuss existing and emerging methods to further explore the field. We begin by giving an overview of the pre-metastatic and metastatic niches in general before focusing on their manifestations in the brain. To conclude, we reflect on the methods usually employed in this field of research and discuss novel approaches in imaging and sequencing. |
format | Online Article Text |
id | pubmed-10298140 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102981402023-06-28 The Brain Pre-Metastatic Niche: Biological and Technical Advancements Geissler, Maximilian Jia, Weiyi Kiraz, Emine Nisanur Kulacz, Ida Liu, Xiao Rombach, Adrian Prinz, Vincent Jussen, Daniel Kokkaliaris, Konstantinos D. Medyouf, Hind Sevenich, Lisa Czabanka, Marcus Broggini, Thomas Int J Mol Sci Review Metastasis, particularly brain metastasis, continues to puzzle researchers to this day, and exploring its molecular basis promises to break ground in developing new strategies for combatting this deadly cancer. In recent years, the research focus has shifted toward the earliest steps in the formation of metastasis. In this regard, significant progress has been achieved in understanding how the primary tumor affects distant organ sites before the arrival of tumor cells. The term pre-metastatic niche was introduced for this concept and encompasses all influences on sites of future metastases, ranging from immunological modulation and ECM remodeling to the softening of the blood–brain barrier. The mechanisms governing the spread of metastasis to the brain remain elusive. However, we begin to understand these processes by looking at the earliest steps in the formation of metastasis. This review aims to present recent findings on the brain pre-metastatic niche and to discuss existing and emerging methods to further explore the field. We begin by giving an overview of the pre-metastatic and metastatic niches in general before focusing on their manifestations in the brain. To conclude, we reflect on the methods usually employed in this field of research and discuss novel approaches in imaging and sequencing. MDPI 2023-06-13 /pmc/articles/PMC10298140/ /pubmed/37373202 http://dx.doi.org/10.3390/ijms241210055 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Geissler, Maximilian Jia, Weiyi Kiraz, Emine Nisanur Kulacz, Ida Liu, Xiao Rombach, Adrian Prinz, Vincent Jussen, Daniel Kokkaliaris, Konstantinos D. Medyouf, Hind Sevenich, Lisa Czabanka, Marcus Broggini, Thomas The Brain Pre-Metastatic Niche: Biological and Technical Advancements |
title | The Brain Pre-Metastatic Niche: Biological and Technical Advancements |
title_full | The Brain Pre-Metastatic Niche: Biological and Technical Advancements |
title_fullStr | The Brain Pre-Metastatic Niche: Biological and Technical Advancements |
title_full_unstemmed | The Brain Pre-Metastatic Niche: Biological and Technical Advancements |
title_short | The Brain Pre-Metastatic Niche: Biological and Technical Advancements |
title_sort | brain pre-metastatic niche: biological and technical advancements |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298140/ https://www.ncbi.nlm.nih.gov/pubmed/37373202 http://dx.doi.org/10.3390/ijms241210055 |
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