Cargando…

The Brain Pre-Metastatic Niche: Biological and Technical Advancements

Metastasis, particularly brain metastasis, continues to puzzle researchers to this day, and exploring its molecular basis promises to break ground in developing new strategies for combatting this deadly cancer. In recent years, the research focus has shifted toward the earliest steps in the formatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Geissler, Maximilian, Jia, Weiyi, Kiraz, Emine Nisanur, Kulacz, Ida, Liu, Xiao, Rombach, Adrian, Prinz, Vincent, Jussen, Daniel, Kokkaliaris, Konstantinos D., Medyouf, Hind, Sevenich, Lisa, Czabanka, Marcus, Broggini, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298140/
https://www.ncbi.nlm.nih.gov/pubmed/37373202
http://dx.doi.org/10.3390/ijms241210055
_version_ 1785064042349461504
author Geissler, Maximilian
Jia, Weiyi
Kiraz, Emine Nisanur
Kulacz, Ida
Liu, Xiao
Rombach, Adrian
Prinz, Vincent
Jussen, Daniel
Kokkaliaris, Konstantinos D.
Medyouf, Hind
Sevenich, Lisa
Czabanka, Marcus
Broggini, Thomas
author_facet Geissler, Maximilian
Jia, Weiyi
Kiraz, Emine Nisanur
Kulacz, Ida
Liu, Xiao
Rombach, Adrian
Prinz, Vincent
Jussen, Daniel
Kokkaliaris, Konstantinos D.
Medyouf, Hind
Sevenich, Lisa
Czabanka, Marcus
Broggini, Thomas
author_sort Geissler, Maximilian
collection PubMed
description Metastasis, particularly brain metastasis, continues to puzzle researchers to this day, and exploring its molecular basis promises to break ground in developing new strategies for combatting this deadly cancer. In recent years, the research focus has shifted toward the earliest steps in the formation of metastasis. In this regard, significant progress has been achieved in understanding how the primary tumor affects distant organ sites before the arrival of tumor cells. The term pre-metastatic niche was introduced for this concept and encompasses all influences on sites of future metastases, ranging from immunological modulation and ECM remodeling to the softening of the blood–brain barrier. The mechanisms governing the spread of metastasis to the brain remain elusive. However, we begin to understand these processes by looking at the earliest steps in the formation of metastasis. This review aims to present recent findings on the brain pre-metastatic niche and to discuss existing and emerging methods to further explore the field. We begin by giving an overview of the pre-metastatic and metastatic niches in general before focusing on their manifestations in the brain. To conclude, we reflect on the methods usually employed in this field of research and discuss novel approaches in imaging and sequencing.
format Online
Article
Text
id pubmed-10298140
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102981402023-06-28 The Brain Pre-Metastatic Niche: Biological and Technical Advancements Geissler, Maximilian Jia, Weiyi Kiraz, Emine Nisanur Kulacz, Ida Liu, Xiao Rombach, Adrian Prinz, Vincent Jussen, Daniel Kokkaliaris, Konstantinos D. Medyouf, Hind Sevenich, Lisa Czabanka, Marcus Broggini, Thomas Int J Mol Sci Review Metastasis, particularly brain metastasis, continues to puzzle researchers to this day, and exploring its molecular basis promises to break ground in developing new strategies for combatting this deadly cancer. In recent years, the research focus has shifted toward the earliest steps in the formation of metastasis. In this regard, significant progress has been achieved in understanding how the primary tumor affects distant organ sites before the arrival of tumor cells. The term pre-metastatic niche was introduced for this concept and encompasses all influences on sites of future metastases, ranging from immunological modulation and ECM remodeling to the softening of the blood–brain barrier. The mechanisms governing the spread of metastasis to the brain remain elusive. However, we begin to understand these processes by looking at the earliest steps in the formation of metastasis. This review aims to present recent findings on the brain pre-metastatic niche and to discuss existing and emerging methods to further explore the field. We begin by giving an overview of the pre-metastatic and metastatic niches in general before focusing on their manifestations in the brain. To conclude, we reflect on the methods usually employed in this field of research and discuss novel approaches in imaging and sequencing. MDPI 2023-06-13 /pmc/articles/PMC10298140/ /pubmed/37373202 http://dx.doi.org/10.3390/ijms241210055 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Geissler, Maximilian
Jia, Weiyi
Kiraz, Emine Nisanur
Kulacz, Ida
Liu, Xiao
Rombach, Adrian
Prinz, Vincent
Jussen, Daniel
Kokkaliaris, Konstantinos D.
Medyouf, Hind
Sevenich, Lisa
Czabanka, Marcus
Broggini, Thomas
The Brain Pre-Metastatic Niche: Biological and Technical Advancements
title The Brain Pre-Metastatic Niche: Biological and Technical Advancements
title_full The Brain Pre-Metastatic Niche: Biological and Technical Advancements
title_fullStr The Brain Pre-Metastatic Niche: Biological and Technical Advancements
title_full_unstemmed The Brain Pre-Metastatic Niche: Biological and Technical Advancements
title_short The Brain Pre-Metastatic Niche: Biological and Technical Advancements
title_sort brain pre-metastatic niche: biological and technical advancements
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298140/
https://www.ncbi.nlm.nih.gov/pubmed/37373202
http://dx.doi.org/10.3390/ijms241210055
work_keys_str_mv AT geisslermaximilian thebrainpremetastaticnichebiologicalandtechnicaladvancements
AT jiaweiyi thebrainpremetastaticnichebiologicalandtechnicaladvancements
AT kirazeminenisanur thebrainpremetastaticnichebiologicalandtechnicaladvancements
AT kulaczida thebrainpremetastaticnichebiologicalandtechnicaladvancements
AT liuxiao thebrainpremetastaticnichebiologicalandtechnicaladvancements
AT rombachadrian thebrainpremetastaticnichebiologicalandtechnicaladvancements
AT prinzvincent thebrainpremetastaticnichebiologicalandtechnicaladvancements
AT jussendaniel thebrainpremetastaticnichebiologicalandtechnicaladvancements
AT kokkaliariskonstantinosd thebrainpremetastaticnichebiologicalandtechnicaladvancements
AT medyoufhind thebrainpremetastaticnichebiologicalandtechnicaladvancements
AT sevenichlisa thebrainpremetastaticnichebiologicalandtechnicaladvancements
AT czabankamarcus thebrainpremetastaticnichebiologicalandtechnicaladvancements
AT brogginithomas thebrainpremetastaticnichebiologicalandtechnicaladvancements
AT geisslermaximilian brainpremetastaticnichebiologicalandtechnicaladvancements
AT jiaweiyi brainpremetastaticnichebiologicalandtechnicaladvancements
AT kirazeminenisanur brainpremetastaticnichebiologicalandtechnicaladvancements
AT kulaczida brainpremetastaticnichebiologicalandtechnicaladvancements
AT liuxiao brainpremetastaticnichebiologicalandtechnicaladvancements
AT rombachadrian brainpremetastaticnichebiologicalandtechnicaladvancements
AT prinzvincent brainpremetastaticnichebiologicalandtechnicaladvancements
AT jussendaniel brainpremetastaticnichebiologicalandtechnicaladvancements
AT kokkaliariskonstantinosd brainpremetastaticnichebiologicalandtechnicaladvancements
AT medyoufhind brainpremetastaticnichebiologicalandtechnicaladvancements
AT sevenichlisa brainpremetastaticnichebiologicalandtechnicaladvancements
AT czabankamarcus brainpremetastaticnichebiologicalandtechnicaladvancements
AT brogginithomas brainpremetastaticnichebiologicalandtechnicaladvancements