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Global and regional estimates of clinical and economic burden of low back pain in high-income countries: a systematic review and meta-analysis

INTRODUCTION: Low back pain (LBP) is a common health problem, and the leading cause of activity limitation and work absence among people of all ages and socioeconomic strata. This study aimed to analyse the clinical and economic burden of LBP in high income countries (HICs) via systematic review and...

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Autores principales: Fatoye, Francis, Gebrye, Tadesse, Ryan, Cormac G., Useh, Ushotanefe, Mbada, Chidozie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298167/
https://www.ncbi.nlm.nih.gov/pubmed/37383269
http://dx.doi.org/10.3389/fpubh.2023.1098100
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author Fatoye, Francis
Gebrye, Tadesse
Ryan, Cormac G.
Useh, Ushotanefe
Mbada, Chidozie
author_facet Fatoye, Francis
Gebrye, Tadesse
Ryan, Cormac G.
Useh, Ushotanefe
Mbada, Chidozie
author_sort Fatoye, Francis
collection PubMed
description INTRODUCTION: Low back pain (LBP) is a common health problem, and the leading cause of activity limitation and work absence among people of all ages and socioeconomic strata. This study aimed to analyse the clinical and economic burden of LBP in high income countries (HICs) via systematic review and meta-analysis. METHODS: A literature search was carried out on PubMed, Medline, CINAHL, PsycINFO, AMED, and Scopus databases was from inception to March 15th, 2023. Studies that assessed the clinical and economic burden of LBP in HICs and published in English language were reviewed. The methodological quality of the included studies was assessed using the Newcastle-Ottawa quality assessment scale (NOS) for cohort studies. Two reviewers, using a predefined data extraction form, independently extracted data. Meta-analyses were conducted for clinical and economic outcomes. RESULTS: The search identified 4,081 potentially relevant articles. Twenty-one studies that met the eligibility criteria were included and reviewed in this systematic review and meta-analysis. The included studies were from the regions of America (n = 5); Europe (n = 12), and the Western Pacific (n = 4). The average annual direct and indirect costs estimate per population for LBP ranged from € 2.3 billion to € 2.6 billion; and € 0.24 billion to $8.15 billion, respectively. In the random effects meta-analysis, the pooled annual rate of hospitalization for LBP was 3.2% (95% confidence interval 0.6%–5.7%). The pooled direct costs and total costs of LBP per patients were USD 9,231 (95% confidence interval −7,126.71–25,588.9) and USD 10,143.1 (95% confidence interval 6,083.59–14,202.6), respectively. DISCUSSION: Low back pain led to high clinical and economic burden in HICs that varied significantly across the geographical contexts. The results of our analysis can be used by clinicians, and policymakers to better allocate resources for prevention and management strategies for LBP to improve health outcomes and reduce the substantial burden associated with the condition. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/#recordDetails?, PROSPERO [CRD42020196335].
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spelling pubmed-102981672023-06-28 Global and regional estimates of clinical and economic burden of low back pain in high-income countries: a systematic review and meta-analysis Fatoye, Francis Gebrye, Tadesse Ryan, Cormac G. Useh, Ushotanefe Mbada, Chidozie Front Public Health Public Health INTRODUCTION: Low back pain (LBP) is a common health problem, and the leading cause of activity limitation and work absence among people of all ages and socioeconomic strata. This study aimed to analyse the clinical and economic burden of LBP in high income countries (HICs) via systematic review and meta-analysis. METHODS: A literature search was carried out on PubMed, Medline, CINAHL, PsycINFO, AMED, and Scopus databases was from inception to March 15th, 2023. Studies that assessed the clinical and economic burden of LBP in HICs and published in English language were reviewed. The methodological quality of the included studies was assessed using the Newcastle-Ottawa quality assessment scale (NOS) for cohort studies. Two reviewers, using a predefined data extraction form, independently extracted data. Meta-analyses were conducted for clinical and economic outcomes. RESULTS: The search identified 4,081 potentially relevant articles. Twenty-one studies that met the eligibility criteria were included and reviewed in this systematic review and meta-analysis. The included studies were from the regions of America (n = 5); Europe (n = 12), and the Western Pacific (n = 4). The average annual direct and indirect costs estimate per population for LBP ranged from € 2.3 billion to € 2.6 billion; and € 0.24 billion to $8.15 billion, respectively. In the random effects meta-analysis, the pooled annual rate of hospitalization for LBP was 3.2% (95% confidence interval 0.6%–5.7%). The pooled direct costs and total costs of LBP per patients were USD 9,231 (95% confidence interval −7,126.71–25,588.9) and USD 10,143.1 (95% confidence interval 6,083.59–14,202.6), respectively. DISCUSSION: Low back pain led to high clinical and economic burden in HICs that varied significantly across the geographical contexts. The results of our analysis can be used by clinicians, and policymakers to better allocate resources for prevention and management strategies for LBP to improve health outcomes and reduce the substantial burden associated with the condition. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/#recordDetails?, PROSPERO [CRD42020196335]. Frontiers Media S.A. 2023-06-09 /pmc/articles/PMC10298167/ /pubmed/37383269 http://dx.doi.org/10.3389/fpubh.2023.1098100 Text en Copyright © 2023 Fatoye, Gebrye, Ryan, Useh and Mbada. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Fatoye, Francis
Gebrye, Tadesse
Ryan, Cormac G.
Useh, Ushotanefe
Mbada, Chidozie
Global and regional estimates of clinical and economic burden of low back pain in high-income countries: a systematic review and meta-analysis
title Global and regional estimates of clinical and economic burden of low back pain in high-income countries: a systematic review and meta-analysis
title_full Global and regional estimates of clinical and economic burden of low back pain in high-income countries: a systematic review and meta-analysis
title_fullStr Global and regional estimates of clinical and economic burden of low back pain in high-income countries: a systematic review and meta-analysis
title_full_unstemmed Global and regional estimates of clinical and economic burden of low back pain in high-income countries: a systematic review and meta-analysis
title_short Global and regional estimates of clinical and economic burden of low back pain in high-income countries: a systematic review and meta-analysis
title_sort global and regional estimates of clinical and economic burden of low back pain in high-income countries: a systematic review and meta-analysis
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298167/
https://www.ncbi.nlm.nih.gov/pubmed/37383269
http://dx.doi.org/10.3389/fpubh.2023.1098100
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