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Unveiling the MUFA–Cancer Connection: Insights from Endogenous and Exogenous Perspectives

Monounsaturated fatty acids (MUFAs) have been the subject of extensive research in the field of cancer due to their potential role in its prevention and treatment. MUFAs can be consumed through the diet or endogenously biosynthesized. Stearoyl-CoA desaturases (SCDs) are key enzymes involved in the e...

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Autores principales: Guo, Zhiqiang, Bergeron, Karl-Frédérik, Lingrand, Marine, Mounier, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298224/
https://www.ncbi.nlm.nih.gov/pubmed/37373069
http://dx.doi.org/10.3390/ijms24129921
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author Guo, Zhiqiang
Bergeron, Karl-Frédérik
Lingrand, Marine
Mounier, Catherine
author_facet Guo, Zhiqiang
Bergeron, Karl-Frédérik
Lingrand, Marine
Mounier, Catherine
author_sort Guo, Zhiqiang
collection PubMed
description Monounsaturated fatty acids (MUFAs) have been the subject of extensive research in the field of cancer due to their potential role in its prevention and treatment. MUFAs can be consumed through the diet or endogenously biosynthesized. Stearoyl-CoA desaturases (SCDs) are key enzymes involved in the endogenous synthesis of MUFAs, and their expression and activity have been found to be increased in various types of cancer. In addition, diets rich in MUFAs have been associated with cancer risk in epidemiological studies for certain types of carcinomas. This review provides an overview of the state-of-the-art literature on the associations between MUFA metabolism and cancer development and progression from human, animal, and cellular studies. We discuss the impact of MUFAs on cancer development, including their effects on cancer cell growth, migration, survival, and cell signaling pathways, to provide new insights on the role of MUFAs in cancer biology.
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spelling pubmed-102982242023-06-28 Unveiling the MUFA–Cancer Connection: Insights from Endogenous and Exogenous Perspectives Guo, Zhiqiang Bergeron, Karl-Frédérik Lingrand, Marine Mounier, Catherine Int J Mol Sci Review Monounsaturated fatty acids (MUFAs) have been the subject of extensive research in the field of cancer due to their potential role in its prevention and treatment. MUFAs can be consumed through the diet or endogenously biosynthesized. Stearoyl-CoA desaturases (SCDs) are key enzymes involved in the endogenous synthesis of MUFAs, and their expression and activity have been found to be increased in various types of cancer. In addition, diets rich in MUFAs have been associated with cancer risk in epidemiological studies for certain types of carcinomas. This review provides an overview of the state-of-the-art literature on the associations between MUFA metabolism and cancer development and progression from human, animal, and cellular studies. We discuss the impact of MUFAs on cancer development, including their effects on cancer cell growth, migration, survival, and cell signaling pathways, to provide new insights on the role of MUFAs in cancer biology. MDPI 2023-06-08 /pmc/articles/PMC10298224/ /pubmed/37373069 http://dx.doi.org/10.3390/ijms24129921 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Guo, Zhiqiang
Bergeron, Karl-Frédérik
Lingrand, Marine
Mounier, Catherine
Unveiling the MUFA–Cancer Connection: Insights from Endogenous and Exogenous Perspectives
title Unveiling the MUFA–Cancer Connection: Insights from Endogenous and Exogenous Perspectives
title_full Unveiling the MUFA–Cancer Connection: Insights from Endogenous and Exogenous Perspectives
title_fullStr Unveiling the MUFA–Cancer Connection: Insights from Endogenous and Exogenous Perspectives
title_full_unstemmed Unveiling the MUFA–Cancer Connection: Insights from Endogenous and Exogenous Perspectives
title_short Unveiling the MUFA–Cancer Connection: Insights from Endogenous and Exogenous Perspectives
title_sort unveiling the mufa–cancer connection: insights from endogenous and exogenous perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298224/
https://www.ncbi.nlm.nih.gov/pubmed/37373069
http://dx.doi.org/10.3390/ijms24129921
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