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Clinical Cancer Research in South America and Potential Health Economic Impacts

Background: Increased global cancer incidence rates have led to a growing demand for cancer diagnosis and treatment, as well as basic and clinical research on the subject. The expansion of clinical cancer trials beyond the borders of highly developed countries has aided the arrival of these assessme...

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Autores principales: de Oliveira Avellar, William, Ferreira, Édria Aparecida, Vieira, Ana Carolina Rodrigues Alves, de Melo, Andreia Cristina, Aran, Veronica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298265/
https://www.ncbi.nlm.nih.gov/pubmed/37372871
http://dx.doi.org/10.3390/healthcare11121753
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author de Oliveira Avellar, William
Ferreira, Édria Aparecida
Vieira, Ana Carolina Rodrigues Alves
de Melo, Andreia Cristina
Aran, Veronica
author_facet de Oliveira Avellar, William
Ferreira, Édria Aparecida
Vieira, Ana Carolina Rodrigues Alves
de Melo, Andreia Cristina
Aran, Veronica
author_sort de Oliveira Avellar, William
collection PubMed
description Background: Increased global cancer incidence rates have led to a growing demand for cancer diagnosis and treatment, as well as basic and clinical research on the subject. The expansion of clinical cancer trials beyond the borders of highly developed countries has aided the arrival of these assessments in South American countries. In this context, this study’s objective is to highlight clinical cancer trial profiles developed and sponsored by pharmaceutical companies and conducted in South American countries from 2010 to 2020. Methods: This study comprises descriptive and retrospective research conducted following a search for clinical trials (phases I, II and III), registered at clinicaltrials.gov, carried out in Latin American countries and sponsored by pharmaceutical companies (“Argentina”, “Brazil”, “Chile”, “Peru”, “Colombia”, “Ecuador”, “Uruguay”, “Venezuela”, “Paraguay”, “Bolivia”), registered between 1 January 2010 and 31 December 2020. A total of 1451 clinical trials were retrieved, of which 200 trials unrelated to cancer were excluded and 646 duplicates were removed, leading to a final total of 605 clinical trials employing qualitative and quantitative analyses. Results: A 122% increase in the number of clinical trial registrations from 2010 to 2020 was noted, with a prevalence of phase III studies (431 trials of a total of 605). Lung (119), breast (100), leukemia (42), prostate (39) and melanoma (32) were the main cancers tested for new drugs. Conclusions: The data reported herein indicate the need for strategic basic and clinical research planning that considers South American epidemic cancer profiles.
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spelling pubmed-102982652023-06-28 Clinical Cancer Research in South America and Potential Health Economic Impacts de Oliveira Avellar, William Ferreira, Édria Aparecida Vieira, Ana Carolina Rodrigues Alves de Melo, Andreia Cristina Aran, Veronica Healthcare (Basel) Article Background: Increased global cancer incidence rates have led to a growing demand for cancer diagnosis and treatment, as well as basic and clinical research on the subject. The expansion of clinical cancer trials beyond the borders of highly developed countries has aided the arrival of these assessments in South American countries. In this context, this study’s objective is to highlight clinical cancer trial profiles developed and sponsored by pharmaceutical companies and conducted in South American countries from 2010 to 2020. Methods: This study comprises descriptive and retrospective research conducted following a search for clinical trials (phases I, II and III), registered at clinicaltrials.gov, carried out in Latin American countries and sponsored by pharmaceutical companies (“Argentina”, “Brazil”, “Chile”, “Peru”, “Colombia”, “Ecuador”, “Uruguay”, “Venezuela”, “Paraguay”, “Bolivia”), registered between 1 January 2010 and 31 December 2020. A total of 1451 clinical trials were retrieved, of which 200 trials unrelated to cancer were excluded and 646 duplicates were removed, leading to a final total of 605 clinical trials employing qualitative and quantitative analyses. Results: A 122% increase in the number of clinical trial registrations from 2010 to 2020 was noted, with a prevalence of phase III studies (431 trials of a total of 605). Lung (119), breast (100), leukemia (42), prostate (39) and melanoma (32) were the main cancers tested for new drugs. Conclusions: The data reported herein indicate the need for strategic basic and clinical research planning that considers South American epidemic cancer profiles. MDPI 2023-06-15 /pmc/articles/PMC10298265/ /pubmed/37372871 http://dx.doi.org/10.3390/healthcare11121753 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
de Oliveira Avellar, William
Ferreira, Édria Aparecida
Vieira, Ana Carolina Rodrigues Alves
de Melo, Andreia Cristina
Aran, Veronica
Clinical Cancer Research in South America and Potential Health Economic Impacts
title Clinical Cancer Research in South America and Potential Health Economic Impacts
title_full Clinical Cancer Research in South America and Potential Health Economic Impacts
title_fullStr Clinical Cancer Research in South America and Potential Health Economic Impacts
title_full_unstemmed Clinical Cancer Research in South America and Potential Health Economic Impacts
title_short Clinical Cancer Research in South America and Potential Health Economic Impacts
title_sort clinical cancer research in south america and potential health economic impacts
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298265/
https://www.ncbi.nlm.nih.gov/pubmed/37372871
http://dx.doi.org/10.3390/healthcare11121753
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