Cargando…

Synthesis and hLDH Inhibitory Activity of Analogues to Natural Products with 2,8-Dioxabicyclo[3.3.1]nonane Scaffold

Human lactate dehydrogenase (hLDH) is a tetrameric enzyme present in almost all tissues. Among its five different isoforms, hLDHA and hLDHB are the predominant ones. In the last few years, hLDHA has emerged as a therapeutic target for the treatment of several kinds of disorders, including cancer and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Salido, Sofía, Alejo-Armijo, Alfonso, Altarejos, Joaquín
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298284/ https://www.ncbi.nlm.nih.gov/pubmed/37373073 http://dx.doi.org/10.3390/ijms24129925

Ejemplares similares

Three-Dimensional Analysis of the Interactions between hLDH5 and Its Inhibitors
por: Poli, Giulio, et al.
Publicado: (2017)

2-Isobutyl-2-phosphabicyclo[3.3.1]nonane 2-selenide
por: Bungu, Peter N., et al.
Publicado: (2009)

(−)-(1S,5R)-2-Oxabicyclo[3.3.1]nonan-3-one
por: Olejniczak, Teresa, et al.
Publicado: (2010)

rac-4,8-Divinylbicyclo[3.3.1]nonane-2,6-dione
por: Orentas, Edvinas, et al.
Publicado: (2009)

9-(Pyrrolidinium-1-yl)-9-boranuidabicyclo[3.3.1]nonane
por: Herbig, Marcus, et al.
Publicado: (2023)

Rapid Access to Azabicyclo[3.3.1]nonanes by a Tandem Diverted Tsuji–Trost Process
por: Steeds, Hannah G., et al.
Publicado: (2020)

(1S*,5R*)-9-Phenyl-9-azabicyclo[3.3.1]nonan-3-one
por: Jiang, Zhen-ju, et al.
Publicado: (2012)

Efficient Synthesis of a New Family of 2,6-Disulfanyl-9-selenabicyclo[3.3.1]nonanes
por: Musalov, Maxim V., et al.
Publicado: (2021)

2,4-Bis(2-methoxyphenyl)-3-azabicyclo[3.3.1]nonan-9-one
por: Parthiban, P., et al.
Publicado: (2009)

2,4-Bis(4-propoxyphenyl)-3-azabicyclo[3.3.1]nonan-9-one
por: Parthiban, P., et al.
Publicado: (2011)

2,4-Bis(3-fluorophenyl)-3-azabicyclo[3.3.1]nonan-9-one
por: Parthiban, P., et al.
Publicado: (2008)

2,4-Bis(3-bromophenyl)-3-azabicyclo[3.3.1]nonan-9-one
por: Parthiban, P., et al.
Publicado: (2008)

2,4-Bis(3-methoxyphenyl)-3-azabicyclo[3.3.1]nonan-9-one
por: Parthiban, P., et al.
Publicado: (2009)

2,4-Bis(3-chlorophenyl)-3-azabicyclo[3.3.1]nonan-9-one
por: Parthiban, P., et al.
Publicado: (2009)

2,4-Bis(4-fluorophenyl)-3-azabicyclo[3.3.1]nonan-9-one
por: Parthiban, P., et al.
Publicado: (2008)

2,4-Bis(2-bromophenyl)-3-azabicyclo[3.3.1]nonan-9-one
por: Parthiban, P., et al.
Publicado: (2008)

2,4-Bis(4-bromophenyl)-3-azabicyclo[3.3.1]nonan-9-one
por: Parthiban, P., et al.
Publicado: (2009)

2,4-Bis(2-chlorophenyl)-3-azabicyclo[3.3.1]nonan-9-one
por: Parthiban, P., et al.
Publicado: (2008)

2,4-Bis(4-chlorophenyl)-3-azabicyclo[3.3.1]nonan-9-one
por: Parthiban, P., et al.
Publicado: (2009)

2,4-Bis(2-fluorophenyl)-3-azabicyclo[3.3.1]nonan-9-one
por: Parthiban, P., et al.
Publicado: (2009)

Synthesis of Analogs to A-Type Proanthocyanidin Natural Products with Enhanced Antimicrobial Properties against Foodborne Microorganisms
por: Cobo, Antonio, et al.
Publicado: (2023)

Homoconjugation vs. Exciton Coupling in Chiral α,β-Unsaturated Bicyclo[3.3.1]nonane Dinitrile and Carboxylic Acids
por: Bagdžiūnas, Gintautas, et al.
Publicado: (2014)

Synthesis of 2,6-Dibromo-9-selenabicyclo[3.3.1]nonane-Based Pyridinium Salts Containing Acetal Groups
por: Musalov, M. V., et al.
Publicado: (2022)

2,4-Bis(4-butoxyphenyl)-3-azabicyclo[3.3.1]nonan-9-one
por: Parthiban, P., et al.
Publicado: (2011)

2,4-Bis(2-ethoxyphenyl)-3-azabicyclo[3.3.1]nonan-9-one
por: Park, Dong Ho, et al.
Publicado: (2012)

2,4-Bis(4-ethoxyphenyl)-3-azabicyclo[3.3.1]nonan-9-one
por: Park, Dong Ho, et al.
Publicado: (2012)

3-Nitroso-2,4,6,8-tetraphenyl-3,7-diazabicyclo[3.3.1]nonan-9-one
por: Natarajan, Sampath, et al.
Publicado: (2011)

Crystal structure of 1-[2,4-bis(4-methoxyphenyl)-3-azabicyclo[3.3.1]nonan-3-yl]ethanone
por: Shreevidhyaa Suressh, V., et al.
Publicado: (2014)

Different routes for the construction of biologically active diversely functionalized bicyclo[3.3.1]nonanes: an exploration of new perspectives for anticancer chemotherapeutics
por: Roy, Nilmadhab, et al.
Publicado: (2023)

2,4-Bis(4-chlorophenyl)-1-methyl-3-azabicyclo[3.3.1]nonan-9-one
por: Parthiban, P., et al.
Publicado: (2010)

2,4-Bis(2-fluorophenyl)-1-methyl-3-azabicyclo[3.3.1]nonan-9-one
por: Parthiban, P., et al.
Publicado: (2009)

1-Methyl-2,4-bis(2-methoxyphenyl)-3-azabicyclo[3.3.1]nonan-9-one
por: Parthiban, P., et al.
Publicado: (2009)

7,7-[Ethane-1,2-diylbis(oxy)]-2-[hydroxy(phenyl)methyl]bicyclo[3.3.1]nonan-3-one
por: Li, Jian, et al.
Publicado: (2014)

2,4-Bis(furan-2-yl)-1,5-dimethyl-3-azabicyclo[3.3.1]nonan-9-one
por: Venkateswaramoorthi, R., et al.
Publicado: (2013)

Crystal structure of 2-(2,4-diphenyl-3-azabicyclo[3.3.1]nonan-9-ylidene)acetonitrile
por: Priya, K., et al.
Publicado: (2015)

2-(2,4-Diphenyl-3-azabicyclo[3.3.1]nonan-9-ylidenehydrazono)-1,3-thiazolidin-4-one
por: Ramachandran, R., et al.
Publicado: (2009)

syn-3-(4-Chlorobenzyl)-1,5-dimethyl-3,7-diazabicyclo[3.3.1]nonan-9-ol
por: Kudryavtsev, Konstantin V., et al.
Publicado: (2012)

Gas-Phase Structure of 3,7,9-tris(trifluoromethylsulfonyl)-3,7,9-triazabicyclo[3.3.1]nonane by GED and Theoretical Calculations
por: Shainyan, Bagrat A., et al.
Publicado: (2023)

2,4-Bis(2-ethoxyphenyl)-7-methyl-3-azabicyclo[3.3.1]nonan-9-one
por: Parthiban, P., et al.
Publicado: (2011)

2,4-Bis(4-ethoxyphenyl)-7-methyl-3-azabicyclo[3.3.1]nonan-9-one
por: Park, Dong Ho, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_8eorl7khl99k5ir5a3782pv75i