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Development of Natural Active Agent-Containing Porous Hydrogel Sheets with High Water Content for Wound Dressings
This work was concerned with the fabrication of a porous hydrogel system suitable for medium to heavy-exudating wounds where traditional hydrogels cannot be used. The hydrogels were based on 2-acrylamido-2-methyl-1-propane sulfonic acid (AMPs). In order to produce the porous structure, additional co...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298319/ https://www.ncbi.nlm.nih.gov/pubmed/37367130 http://dx.doi.org/10.3390/gels9060459 |
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author | Pinthong, Thanyaporn Yooyod, Maytinee Daengmankhong, Jinjutha Tuancharoensri, Nantaprapa Mahasaranon, Sararat Viyoch, Jarupa Jongjitwimol, Jirapas Ross, Sukunya Ross, Gareth M. |
author_facet | Pinthong, Thanyaporn Yooyod, Maytinee Daengmankhong, Jinjutha Tuancharoensri, Nantaprapa Mahasaranon, Sararat Viyoch, Jarupa Jongjitwimol, Jirapas Ross, Sukunya Ross, Gareth M. |
author_sort | Pinthong, Thanyaporn |
collection | PubMed |
description | This work was concerned with the fabrication of a porous hydrogel system suitable for medium to heavy-exudating wounds where traditional hydrogels cannot be used. The hydrogels were based on 2-acrylamido-2-methyl-1-propane sulfonic acid (AMPs). In order to produce the porous structure, additional components were added (acid, blowing agent, foam stabilizer). Manuka honey (MH) was also incorporated at concentrations of 1 and 10% w/w. The hydrogel samples were characterized for morphology via scanning electron microscopy, mechanical rheology, swelling using a gravimetric method, surface absorption, and cell cytotoxicity. The results confirmed the formation of porous hydrogels (PH) with pore sizes ranging from ~50–110 µm. The swelling performance showed that the non-porous hydrogel (NPH) swelled to ~2000%, while PH weight increased ~5000%. Additionally, the use of a surface absorption technique showed that the PH absorbed 10 μL in <3000 ms, and NPH absorbed <1 μL over the same time. Incorporating MH the enhanced gel appearance and mechanical properties, including smaller pores and linear swelling. In summary, the PH produced in this study had excellent swelling performance with rapid absorption of surface liquid. Therefore, these materials have the potential to expand the applicability of hydrogels to a range of wound types, as they can both donate and absorb fluid. |
format | Online Article Text |
id | pubmed-10298319 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102983192023-06-28 Development of Natural Active Agent-Containing Porous Hydrogel Sheets with High Water Content for Wound Dressings Pinthong, Thanyaporn Yooyod, Maytinee Daengmankhong, Jinjutha Tuancharoensri, Nantaprapa Mahasaranon, Sararat Viyoch, Jarupa Jongjitwimol, Jirapas Ross, Sukunya Ross, Gareth M. Gels Article This work was concerned with the fabrication of a porous hydrogel system suitable for medium to heavy-exudating wounds where traditional hydrogels cannot be used. The hydrogels were based on 2-acrylamido-2-methyl-1-propane sulfonic acid (AMPs). In order to produce the porous structure, additional components were added (acid, blowing agent, foam stabilizer). Manuka honey (MH) was also incorporated at concentrations of 1 and 10% w/w. The hydrogel samples were characterized for morphology via scanning electron microscopy, mechanical rheology, swelling using a gravimetric method, surface absorption, and cell cytotoxicity. The results confirmed the formation of porous hydrogels (PH) with pore sizes ranging from ~50–110 µm. The swelling performance showed that the non-porous hydrogel (NPH) swelled to ~2000%, while PH weight increased ~5000%. Additionally, the use of a surface absorption technique showed that the PH absorbed 10 μL in <3000 ms, and NPH absorbed <1 μL over the same time. Incorporating MH the enhanced gel appearance and mechanical properties, including smaller pores and linear swelling. In summary, the PH produced in this study had excellent swelling performance with rapid absorption of surface liquid. Therefore, these materials have the potential to expand the applicability of hydrogels to a range of wound types, as they can both donate and absorb fluid. MDPI 2023-06-03 /pmc/articles/PMC10298319/ /pubmed/37367130 http://dx.doi.org/10.3390/gels9060459 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pinthong, Thanyaporn Yooyod, Maytinee Daengmankhong, Jinjutha Tuancharoensri, Nantaprapa Mahasaranon, Sararat Viyoch, Jarupa Jongjitwimol, Jirapas Ross, Sukunya Ross, Gareth M. Development of Natural Active Agent-Containing Porous Hydrogel Sheets with High Water Content for Wound Dressings |
title | Development of Natural Active Agent-Containing Porous Hydrogel Sheets with High Water Content for Wound Dressings |
title_full | Development of Natural Active Agent-Containing Porous Hydrogel Sheets with High Water Content for Wound Dressings |
title_fullStr | Development of Natural Active Agent-Containing Porous Hydrogel Sheets with High Water Content for Wound Dressings |
title_full_unstemmed | Development of Natural Active Agent-Containing Porous Hydrogel Sheets with High Water Content for Wound Dressings |
title_short | Development of Natural Active Agent-Containing Porous Hydrogel Sheets with High Water Content for Wound Dressings |
title_sort | development of natural active agent-containing porous hydrogel sheets with high water content for wound dressings |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298319/ https://www.ncbi.nlm.nih.gov/pubmed/37367130 http://dx.doi.org/10.3390/gels9060459 |
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