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Development of Natural Active Agent-Containing Porous Hydrogel Sheets with High Water Content for Wound Dressings

This work was concerned with the fabrication of a porous hydrogel system suitable for medium to heavy-exudating wounds where traditional hydrogels cannot be used. The hydrogels were based on 2-acrylamido-2-methyl-1-propane sulfonic acid (AMPs). In order to produce the porous structure, additional co...

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Autores principales: Pinthong, Thanyaporn, Yooyod, Maytinee, Daengmankhong, Jinjutha, Tuancharoensri, Nantaprapa, Mahasaranon, Sararat, Viyoch, Jarupa, Jongjitwimol, Jirapas, Ross, Sukunya, Ross, Gareth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298319/
https://www.ncbi.nlm.nih.gov/pubmed/37367130
http://dx.doi.org/10.3390/gels9060459
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author Pinthong, Thanyaporn
Yooyod, Maytinee
Daengmankhong, Jinjutha
Tuancharoensri, Nantaprapa
Mahasaranon, Sararat
Viyoch, Jarupa
Jongjitwimol, Jirapas
Ross, Sukunya
Ross, Gareth M.
author_facet Pinthong, Thanyaporn
Yooyod, Maytinee
Daengmankhong, Jinjutha
Tuancharoensri, Nantaprapa
Mahasaranon, Sararat
Viyoch, Jarupa
Jongjitwimol, Jirapas
Ross, Sukunya
Ross, Gareth M.
author_sort Pinthong, Thanyaporn
collection PubMed
description This work was concerned with the fabrication of a porous hydrogel system suitable for medium to heavy-exudating wounds where traditional hydrogels cannot be used. The hydrogels were based on 2-acrylamido-2-methyl-1-propane sulfonic acid (AMPs). In order to produce the porous structure, additional components were added (acid, blowing agent, foam stabilizer). Manuka honey (MH) was also incorporated at concentrations of 1 and 10% w/w. The hydrogel samples were characterized for morphology via scanning electron microscopy, mechanical rheology, swelling using a gravimetric method, surface absorption, and cell cytotoxicity. The results confirmed the formation of porous hydrogels (PH) with pore sizes ranging from ~50–110 µm. The swelling performance showed that the non-porous hydrogel (NPH) swelled to ~2000%, while PH weight increased ~5000%. Additionally, the use of a surface absorption technique showed that the PH absorbed 10 μL in <3000 ms, and NPH absorbed <1 μL over the same time. Incorporating MH the enhanced gel appearance and mechanical properties, including smaller pores and linear swelling. In summary, the PH produced in this study had excellent swelling performance with rapid absorption of surface liquid. Therefore, these materials have the potential to expand the applicability of hydrogels to a range of wound types, as they can both donate and absorb fluid.
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spelling pubmed-102983192023-06-28 Development of Natural Active Agent-Containing Porous Hydrogel Sheets with High Water Content for Wound Dressings Pinthong, Thanyaporn Yooyod, Maytinee Daengmankhong, Jinjutha Tuancharoensri, Nantaprapa Mahasaranon, Sararat Viyoch, Jarupa Jongjitwimol, Jirapas Ross, Sukunya Ross, Gareth M. Gels Article This work was concerned with the fabrication of a porous hydrogel system suitable for medium to heavy-exudating wounds where traditional hydrogels cannot be used. The hydrogels were based on 2-acrylamido-2-methyl-1-propane sulfonic acid (AMPs). In order to produce the porous structure, additional components were added (acid, blowing agent, foam stabilizer). Manuka honey (MH) was also incorporated at concentrations of 1 and 10% w/w. The hydrogel samples were characterized for morphology via scanning electron microscopy, mechanical rheology, swelling using a gravimetric method, surface absorption, and cell cytotoxicity. The results confirmed the formation of porous hydrogels (PH) with pore sizes ranging from ~50–110 µm. The swelling performance showed that the non-porous hydrogel (NPH) swelled to ~2000%, while PH weight increased ~5000%. Additionally, the use of a surface absorption technique showed that the PH absorbed 10 μL in <3000 ms, and NPH absorbed <1 μL over the same time. Incorporating MH the enhanced gel appearance and mechanical properties, including smaller pores and linear swelling. In summary, the PH produced in this study had excellent swelling performance with rapid absorption of surface liquid. Therefore, these materials have the potential to expand the applicability of hydrogels to a range of wound types, as they can both donate and absorb fluid. MDPI 2023-06-03 /pmc/articles/PMC10298319/ /pubmed/37367130 http://dx.doi.org/10.3390/gels9060459 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pinthong, Thanyaporn
Yooyod, Maytinee
Daengmankhong, Jinjutha
Tuancharoensri, Nantaprapa
Mahasaranon, Sararat
Viyoch, Jarupa
Jongjitwimol, Jirapas
Ross, Sukunya
Ross, Gareth M.
Development of Natural Active Agent-Containing Porous Hydrogel Sheets with High Water Content for Wound Dressings
title Development of Natural Active Agent-Containing Porous Hydrogel Sheets with High Water Content for Wound Dressings
title_full Development of Natural Active Agent-Containing Porous Hydrogel Sheets with High Water Content for Wound Dressings
title_fullStr Development of Natural Active Agent-Containing Porous Hydrogel Sheets with High Water Content for Wound Dressings
title_full_unstemmed Development of Natural Active Agent-Containing Porous Hydrogel Sheets with High Water Content for Wound Dressings
title_short Development of Natural Active Agent-Containing Porous Hydrogel Sheets with High Water Content for Wound Dressings
title_sort development of natural active agent-containing porous hydrogel sheets with high water content for wound dressings
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298319/
https://www.ncbi.nlm.nih.gov/pubmed/37367130
http://dx.doi.org/10.3390/gels9060459
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