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Hollow Particles Obtained by Prilling and Supercritical Drying as a Potential Conformable Dressing for Chronic Wounds
The production of aerogels for different applications has been widely known, but the use of polysaccharide-based aerogels for pharmaceutical applications, specifically as drug carriers for wound healing, is being recently explored. The main focus of this work is the production and characterization o...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298422/ https://www.ncbi.nlm.nih.gov/pubmed/37367162 http://dx.doi.org/10.3390/gels9060492 |
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author | Sellitto, Maria Rosaria Amante, Chiara Aquino, Rita Patrizia Russo, Paola Rodríguez-Dorado, Rosalía Neagu, Monica García-González, Carlos A. Adami, Renata Del Gaudio, Pasquale |
author_facet | Sellitto, Maria Rosaria Amante, Chiara Aquino, Rita Patrizia Russo, Paola Rodríguez-Dorado, Rosalía Neagu, Monica García-González, Carlos A. Adami, Renata Del Gaudio, Pasquale |
author_sort | Sellitto, Maria Rosaria |
collection | PubMed |
description | The production of aerogels for different applications has been widely known, but the use of polysaccharide-based aerogels for pharmaceutical applications, specifically as drug carriers for wound healing, is being recently explored. The main focus of this work is the production and characterization of drug-loaded aerogel capsules through prilling in tandem with supercritical extraction. In particular, drug-loaded particles were produced by a recently developed inverse gelation method through prilling in a coaxial configuration. Particles were loaded with ketoprofen lysinate, which was used as a model drug. The core-shell particles manufactured by prilling were subjected to a supercritical drying process with CO(2) that led to capsules formed by a wide hollow cavity and a tunable thin aerogel layer (40 μm) made of alginate, which presented good textural properties in terms of porosity (89.9% and 95.3%) and a surface area up to 417.0 m(2)/g. Such properties allowed the hollow aerogel particles to absorb a high amount of wound fluid moving very quickly (less than 30 s) into a conformable hydrogel in the wound cavity, prolonging drug release (till 72 h) due to the in situ formed hydrogel that acted as a barrier to drug diffusion. |
format | Online Article Text |
id | pubmed-10298422 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102984222023-06-28 Hollow Particles Obtained by Prilling and Supercritical Drying as a Potential Conformable Dressing for Chronic Wounds Sellitto, Maria Rosaria Amante, Chiara Aquino, Rita Patrizia Russo, Paola Rodríguez-Dorado, Rosalía Neagu, Monica García-González, Carlos A. Adami, Renata Del Gaudio, Pasquale Gels Article The production of aerogels for different applications has been widely known, but the use of polysaccharide-based aerogels for pharmaceutical applications, specifically as drug carriers for wound healing, is being recently explored. The main focus of this work is the production and characterization of drug-loaded aerogel capsules through prilling in tandem with supercritical extraction. In particular, drug-loaded particles were produced by a recently developed inverse gelation method through prilling in a coaxial configuration. Particles were loaded with ketoprofen lysinate, which was used as a model drug. The core-shell particles manufactured by prilling were subjected to a supercritical drying process with CO(2) that led to capsules formed by a wide hollow cavity and a tunable thin aerogel layer (40 μm) made of alginate, which presented good textural properties in terms of porosity (89.9% and 95.3%) and a surface area up to 417.0 m(2)/g. Such properties allowed the hollow aerogel particles to absorb a high amount of wound fluid moving very quickly (less than 30 s) into a conformable hydrogel in the wound cavity, prolonging drug release (till 72 h) due to the in situ formed hydrogel that acted as a barrier to drug diffusion. MDPI 2023-06-16 /pmc/articles/PMC10298422/ /pubmed/37367162 http://dx.doi.org/10.3390/gels9060492 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sellitto, Maria Rosaria Amante, Chiara Aquino, Rita Patrizia Russo, Paola Rodríguez-Dorado, Rosalía Neagu, Monica García-González, Carlos A. Adami, Renata Del Gaudio, Pasquale Hollow Particles Obtained by Prilling and Supercritical Drying as a Potential Conformable Dressing for Chronic Wounds |
title | Hollow Particles Obtained by Prilling and Supercritical Drying as a Potential Conformable Dressing for Chronic Wounds |
title_full | Hollow Particles Obtained by Prilling and Supercritical Drying as a Potential Conformable Dressing for Chronic Wounds |
title_fullStr | Hollow Particles Obtained by Prilling and Supercritical Drying as a Potential Conformable Dressing for Chronic Wounds |
title_full_unstemmed | Hollow Particles Obtained by Prilling and Supercritical Drying as a Potential Conformable Dressing for Chronic Wounds |
title_short | Hollow Particles Obtained by Prilling and Supercritical Drying as a Potential Conformable Dressing for Chronic Wounds |
title_sort | hollow particles obtained by prilling and supercritical drying as a potential conformable dressing for chronic wounds |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298422/ https://www.ncbi.nlm.nih.gov/pubmed/37367162 http://dx.doi.org/10.3390/gels9060492 |
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