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Risk Factors for Death or Cardiovascular Events after Acute Coronary Syndrome in Patients with Myeloproliferative Neoplasms

Patients with myeloproliferative neoplasms (MPNs) are at increased risk of cardiovascular disease (CVD), including acute coronary syndrome (ACS). However, data on long-term outcomes of patients with MPN who have had ACS and risk factors for all-cause death or CV events post-ACS hospitalization are l...

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Autores principales: Leiva, Orly, Jenkins, Andrew, Rosovsky, Rachel P., Leaf, Rebecca K., Goodarzi, Katayoon, Hobbs, Gabriela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298451/
https://www.ncbi.nlm.nih.gov/pubmed/37367089
http://dx.doi.org/10.3390/hematolrep15020040
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author Leiva, Orly
Jenkins, Andrew
Rosovsky, Rachel P.
Leaf, Rebecca K.
Goodarzi, Katayoon
Hobbs, Gabriela
author_facet Leiva, Orly
Jenkins, Andrew
Rosovsky, Rachel P.
Leaf, Rebecca K.
Goodarzi, Katayoon
Hobbs, Gabriela
author_sort Leiva, Orly
collection PubMed
description Patients with myeloproliferative neoplasms (MPNs) are at increased risk of cardiovascular disease (CVD), including acute coronary syndrome (ACS). However, data on long-term outcomes of patients with MPN who have had ACS and risk factors for all-cause death or CV events post-ACS hospitalization are lacking. We conducted a single-center study of 41 consecutive patients with MPN with ACS hospitalization after MPN diagnosis. After a median follow-up of 80 months after ACS hospitalization, 31 (76%) experienced death or a CV event (myocardial infarction, ischemic stroke, or heart failure hospitalization). After multivariable Cox proportional hazards regression, index ACS within 12 months of MPN diagnosis (HR 3.84, 95% CI 1.44–10.19), WBC ≥ 20 K/µL (HR 9.10, 95% CI 2.71–30.52), JAK2 mutation (HR 3.71, 95% CI 1.22–11.22), and prior CVD (HR 2.60, 95% CI 1.12–6.08) were associated with increased death or CV events. Further studies are warranted to improve cardiovascular outcomes in this patient population.
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spelling pubmed-102984512023-06-28 Risk Factors for Death or Cardiovascular Events after Acute Coronary Syndrome in Patients with Myeloproliferative Neoplasms Leiva, Orly Jenkins, Andrew Rosovsky, Rachel P. Leaf, Rebecca K. Goodarzi, Katayoon Hobbs, Gabriela Hematol Rep Brief Report Patients with myeloproliferative neoplasms (MPNs) are at increased risk of cardiovascular disease (CVD), including acute coronary syndrome (ACS). However, data on long-term outcomes of patients with MPN who have had ACS and risk factors for all-cause death or CV events post-ACS hospitalization are lacking. We conducted a single-center study of 41 consecutive patients with MPN with ACS hospitalization after MPN diagnosis. After a median follow-up of 80 months after ACS hospitalization, 31 (76%) experienced death or a CV event (myocardial infarction, ischemic stroke, or heart failure hospitalization). After multivariable Cox proportional hazards regression, index ACS within 12 months of MPN diagnosis (HR 3.84, 95% CI 1.44–10.19), WBC ≥ 20 K/µL (HR 9.10, 95% CI 2.71–30.52), JAK2 mutation (HR 3.71, 95% CI 1.22–11.22), and prior CVD (HR 2.60, 95% CI 1.12–6.08) were associated with increased death or CV events. Further studies are warranted to improve cardiovascular outcomes in this patient population. MDPI 2023-06-07 /pmc/articles/PMC10298451/ /pubmed/37367089 http://dx.doi.org/10.3390/hematolrep15020040 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Leiva, Orly
Jenkins, Andrew
Rosovsky, Rachel P.
Leaf, Rebecca K.
Goodarzi, Katayoon
Hobbs, Gabriela
Risk Factors for Death or Cardiovascular Events after Acute Coronary Syndrome in Patients with Myeloproliferative Neoplasms
title Risk Factors for Death or Cardiovascular Events after Acute Coronary Syndrome in Patients with Myeloproliferative Neoplasms
title_full Risk Factors for Death or Cardiovascular Events after Acute Coronary Syndrome in Patients with Myeloproliferative Neoplasms
title_fullStr Risk Factors for Death or Cardiovascular Events after Acute Coronary Syndrome in Patients with Myeloproliferative Neoplasms
title_full_unstemmed Risk Factors for Death or Cardiovascular Events after Acute Coronary Syndrome in Patients with Myeloproliferative Neoplasms
title_short Risk Factors for Death or Cardiovascular Events after Acute Coronary Syndrome in Patients with Myeloproliferative Neoplasms
title_sort risk factors for death or cardiovascular events after acute coronary syndrome in patients with myeloproliferative neoplasms
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298451/
https://www.ncbi.nlm.nih.gov/pubmed/37367089
http://dx.doi.org/10.3390/hematolrep15020040
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