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Plants as the Extended Phenotype of Endophytes—The Actual Source of Bioactive Compounds

For thousands of years, plants have been used for their medicinal properties. The industrial production of plant-beneficial compounds is facing many drawbacks, such as seasonal dependence and troublesome extraction and purification processes, which have led to many species being on the edge of extin...

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Autores principales: Rutkowska, Natalia, Drożdżyński, Piotr, Ryngajłło, Małgorzata, Marchut-Mikołajczyk, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298476/
https://www.ncbi.nlm.nih.gov/pubmed/37373241
http://dx.doi.org/10.3390/ijms241210096
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author Rutkowska, Natalia
Drożdżyński, Piotr
Ryngajłło, Małgorzata
Marchut-Mikołajczyk, Olga
author_facet Rutkowska, Natalia
Drożdżyński, Piotr
Ryngajłło, Małgorzata
Marchut-Mikołajczyk, Olga
author_sort Rutkowska, Natalia
collection PubMed
description For thousands of years, plants have been used for their medicinal properties. The industrial production of plant-beneficial compounds is facing many drawbacks, such as seasonal dependence and troublesome extraction and purification processes, which have led to many species being on the edge of extinction. As the demand for compounds applicable to, e.g., cancer treatment, is still growing, there is a need to develop sustainable production processes. The industrial potential of the endophytic microorganisms residing within plant tissues is undeniable, as they are often able to produce, in vitro, similar to or even the same compounds as their hosts. The peculiar conditions of the endophytic lifestyle raise questions about the molecular background of the biosynthesis of these bioactive compounds in planta, and the actual producer, whether it is the plant itself or its residents. Extending this knowledge is crucial to overcoming the current limitations in the implementation of endophytes for larger-scale production. In this review, we focus on the possible routes of the synthesis of host-specific compounds in planta by their endophytes.
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spelling pubmed-102984762023-06-28 Plants as the Extended Phenotype of Endophytes—The Actual Source of Bioactive Compounds Rutkowska, Natalia Drożdżyński, Piotr Ryngajłło, Małgorzata Marchut-Mikołajczyk, Olga Int J Mol Sci Review For thousands of years, plants have been used for their medicinal properties. The industrial production of plant-beneficial compounds is facing many drawbacks, such as seasonal dependence and troublesome extraction and purification processes, which have led to many species being on the edge of extinction. As the demand for compounds applicable to, e.g., cancer treatment, is still growing, there is a need to develop sustainable production processes. The industrial potential of the endophytic microorganisms residing within plant tissues is undeniable, as they are often able to produce, in vitro, similar to or even the same compounds as their hosts. The peculiar conditions of the endophytic lifestyle raise questions about the molecular background of the biosynthesis of these bioactive compounds in planta, and the actual producer, whether it is the plant itself or its residents. Extending this knowledge is crucial to overcoming the current limitations in the implementation of endophytes for larger-scale production. In this review, we focus on the possible routes of the synthesis of host-specific compounds in planta by their endophytes. MDPI 2023-06-13 /pmc/articles/PMC10298476/ /pubmed/37373241 http://dx.doi.org/10.3390/ijms241210096 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rutkowska, Natalia
Drożdżyński, Piotr
Ryngajłło, Małgorzata
Marchut-Mikołajczyk, Olga
Plants as the Extended Phenotype of Endophytes—The Actual Source of Bioactive Compounds
title Plants as the Extended Phenotype of Endophytes—The Actual Source of Bioactive Compounds
title_full Plants as the Extended Phenotype of Endophytes—The Actual Source of Bioactive Compounds
title_fullStr Plants as the Extended Phenotype of Endophytes—The Actual Source of Bioactive Compounds
title_full_unstemmed Plants as the Extended Phenotype of Endophytes—The Actual Source of Bioactive Compounds
title_short Plants as the Extended Phenotype of Endophytes—The Actual Source of Bioactive Compounds
title_sort plants as the extended phenotype of endophytes—the actual source of bioactive compounds
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298476/
https://www.ncbi.nlm.nih.gov/pubmed/37373241
http://dx.doi.org/10.3390/ijms241210096
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