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Plants as the Extended Phenotype of Endophytes—The Actual Source of Bioactive Compounds
For thousands of years, plants have been used for their medicinal properties. The industrial production of plant-beneficial compounds is facing many drawbacks, such as seasonal dependence and troublesome extraction and purification processes, which have led to many species being on the edge of extin...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298476/ https://www.ncbi.nlm.nih.gov/pubmed/37373241 http://dx.doi.org/10.3390/ijms241210096 |
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author | Rutkowska, Natalia Drożdżyński, Piotr Ryngajłło, Małgorzata Marchut-Mikołajczyk, Olga |
author_facet | Rutkowska, Natalia Drożdżyński, Piotr Ryngajłło, Małgorzata Marchut-Mikołajczyk, Olga |
author_sort | Rutkowska, Natalia |
collection | PubMed |
description | For thousands of years, plants have been used for their medicinal properties. The industrial production of plant-beneficial compounds is facing many drawbacks, such as seasonal dependence and troublesome extraction and purification processes, which have led to many species being on the edge of extinction. As the demand for compounds applicable to, e.g., cancer treatment, is still growing, there is a need to develop sustainable production processes. The industrial potential of the endophytic microorganisms residing within plant tissues is undeniable, as they are often able to produce, in vitro, similar to or even the same compounds as their hosts. The peculiar conditions of the endophytic lifestyle raise questions about the molecular background of the biosynthesis of these bioactive compounds in planta, and the actual producer, whether it is the plant itself or its residents. Extending this knowledge is crucial to overcoming the current limitations in the implementation of endophytes for larger-scale production. In this review, we focus on the possible routes of the synthesis of host-specific compounds in planta by their endophytes. |
format | Online Article Text |
id | pubmed-10298476 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102984762023-06-28 Plants as the Extended Phenotype of Endophytes—The Actual Source of Bioactive Compounds Rutkowska, Natalia Drożdżyński, Piotr Ryngajłło, Małgorzata Marchut-Mikołajczyk, Olga Int J Mol Sci Review For thousands of years, plants have been used for their medicinal properties. The industrial production of plant-beneficial compounds is facing many drawbacks, such as seasonal dependence and troublesome extraction and purification processes, which have led to many species being on the edge of extinction. As the demand for compounds applicable to, e.g., cancer treatment, is still growing, there is a need to develop sustainable production processes. The industrial potential of the endophytic microorganisms residing within plant tissues is undeniable, as they are often able to produce, in vitro, similar to or even the same compounds as their hosts. The peculiar conditions of the endophytic lifestyle raise questions about the molecular background of the biosynthesis of these bioactive compounds in planta, and the actual producer, whether it is the plant itself or its residents. Extending this knowledge is crucial to overcoming the current limitations in the implementation of endophytes for larger-scale production. In this review, we focus on the possible routes of the synthesis of host-specific compounds in planta by their endophytes. MDPI 2023-06-13 /pmc/articles/PMC10298476/ /pubmed/37373241 http://dx.doi.org/10.3390/ijms241210096 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rutkowska, Natalia Drożdżyński, Piotr Ryngajłło, Małgorzata Marchut-Mikołajczyk, Olga Plants as the Extended Phenotype of Endophytes—The Actual Source of Bioactive Compounds |
title | Plants as the Extended Phenotype of Endophytes—The Actual Source of Bioactive Compounds |
title_full | Plants as the Extended Phenotype of Endophytes—The Actual Source of Bioactive Compounds |
title_fullStr | Plants as the Extended Phenotype of Endophytes—The Actual Source of Bioactive Compounds |
title_full_unstemmed | Plants as the Extended Phenotype of Endophytes—The Actual Source of Bioactive Compounds |
title_short | Plants as the Extended Phenotype of Endophytes—The Actual Source of Bioactive Compounds |
title_sort | plants as the extended phenotype of endophytes—the actual source of bioactive compounds |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298476/ https://www.ncbi.nlm.nih.gov/pubmed/37373241 http://dx.doi.org/10.3390/ijms241210096 |
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