The Role of EMT-Related lncRNAs in Ovarian Cancer

Ovarian cancer (OC) is one of the deadliest cancers worldwide; late diagnosis and drug resistance are two major factors often responsible for high morbidity and treatment failure. Epithelial-to-mesenchymal transition (EMT) is a dynamic process that has been closely linked with cancer. Long non-codin...

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Autores principales: Lampropoulou, Dimitra Ioanna, Papadimitriou, Marios, Papadimitriou, Christos, Filippou, Dimitrios, Kourlaba, Georgia, Aravantinos, Gerasimos, Gazouli, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298523/
https://www.ncbi.nlm.nih.gov/pubmed/37373222
http://dx.doi.org/10.3390/ijms241210079
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author Lampropoulou, Dimitra Ioanna
Papadimitriou, Marios
Papadimitriou, Christos
Filippou, Dimitrios
Kourlaba, Georgia
Aravantinos, Gerasimos
Gazouli, Maria
author_facet Lampropoulou, Dimitra Ioanna
Papadimitriou, Marios
Papadimitriou, Christos
Filippou, Dimitrios
Kourlaba, Georgia
Aravantinos, Gerasimos
Gazouli, Maria
author_sort Lampropoulou, Dimitra Ioanna
collection PubMed
description Ovarian cancer (OC) is one of the deadliest cancers worldwide; late diagnosis and drug resistance are two major factors often responsible for high morbidity and treatment failure. Epithelial-to-mesenchymal transition (EMT) is a dynamic process that has been closely linked with cancer. Long non-coding RNAs (lncRNAs) have been also associated with several cancer-related mechanisms, including EMT. We conducted a literature search in the PubMed database in order to sum up and discuss the role of lncRNAs in regulating OC-related EMT and their underlying mechanisms. Seventy (70) original research articles were identified, as of 23 April 2023. Our review concluded that the dysregulation of lncRNAs is highly associated with EMT-mediated OC progression. A comprehensive understanding of lncRNAs’ mechanisms in OC will help in identifying novel and sensitive biomarkers and therapeutic targets for this malignancy.
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spelling pubmed-102985232023-06-28 The Role of EMT-Related lncRNAs in Ovarian Cancer Lampropoulou, Dimitra Ioanna Papadimitriou, Marios Papadimitriou, Christos Filippou, Dimitrios Kourlaba, Georgia Aravantinos, Gerasimos Gazouli, Maria Int J Mol Sci Review Ovarian cancer (OC) is one of the deadliest cancers worldwide; late diagnosis and drug resistance are two major factors often responsible for high morbidity and treatment failure. Epithelial-to-mesenchymal transition (EMT) is a dynamic process that has been closely linked with cancer. Long non-coding RNAs (lncRNAs) have been also associated with several cancer-related mechanisms, including EMT. We conducted a literature search in the PubMed database in order to sum up and discuss the role of lncRNAs in regulating OC-related EMT and their underlying mechanisms. Seventy (70) original research articles were identified, as of 23 April 2023. Our review concluded that the dysregulation of lncRNAs is highly associated with EMT-mediated OC progression. A comprehensive understanding of lncRNAs’ mechanisms in OC will help in identifying novel and sensitive biomarkers and therapeutic targets for this malignancy. MDPI 2023-06-13 /pmc/articles/PMC10298523/ /pubmed/37373222 http://dx.doi.org/10.3390/ijms241210079 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lampropoulou, Dimitra Ioanna
Papadimitriou, Marios
Papadimitriou, Christos
Filippou, Dimitrios
Kourlaba, Georgia
Aravantinos, Gerasimos
Gazouli, Maria
The Role of EMT-Related lncRNAs in Ovarian Cancer
title The Role of EMT-Related lncRNAs in Ovarian Cancer
title_full The Role of EMT-Related lncRNAs in Ovarian Cancer
title_fullStr The Role of EMT-Related lncRNAs in Ovarian Cancer
title_full_unstemmed The Role of EMT-Related lncRNAs in Ovarian Cancer
title_short The Role of EMT-Related lncRNAs in Ovarian Cancer
title_sort role of emt-related lncrnas in ovarian cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298523/
https://www.ncbi.nlm.nih.gov/pubmed/37373222
http://dx.doi.org/10.3390/ijms241210079
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