Mastocytosis and Skin Cancer: The Current State of Knowledge

Mastocytosis is a heterogeneous group of diseases associated with excessive proliferation and accumulation of mast cells in different organs. Recent studies have demonstrated that patients suffering from mastocytosis face an increased risk of melanoma and non-melanoma skin cancer. The cause of this...

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Autores principales: Kaszuba, Agnieszka, Sławińska, Martyna, Żółkiewicz, Jakub, Sobjanek, Michał, Nowicki, Roman J., Lange, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298540/
https://www.ncbi.nlm.nih.gov/pubmed/37372988
http://dx.doi.org/10.3390/ijms24129840
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author Kaszuba, Agnieszka
Sławińska, Martyna
Żółkiewicz, Jakub
Sobjanek, Michał
Nowicki, Roman J.
Lange, Magdalena
author_facet Kaszuba, Agnieszka
Sławińska, Martyna
Żółkiewicz, Jakub
Sobjanek, Michał
Nowicki, Roman J.
Lange, Magdalena
author_sort Kaszuba, Agnieszka
collection PubMed
description Mastocytosis is a heterogeneous group of diseases associated with excessive proliferation and accumulation of mast cells in different organs. Recent studies have demonstrated that patients suffering from mastocytosis face an increased risk of melanoma and non-melanoma skin cancer. The cause of this has not yet been clearly identified. In the literature, the potential influence of several factors has been suggested, including genetic background, the role of cytokines produced by mast cells, iatrogenic and hormonal factors. The article summarizes the current state of knowledge regarding the epidemiology, pathogenesis, diagnosis, and management of skin neoplasia in mastocytosis patients.
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spelling pubmed-102985402023-06-28 Mastocytosis and Skin Cancer: The Current State of Knowledge Kaszuba, Agnieszka Sławińska, Martyna Żółkiewicz, Jakub Sobjanek, Michał Nowicki, Roman J. Lange, Magdalena Int J Mol Sci Review Mastocytosis is a heterogeneous group of diseases associated with excessive proliferation and accumulation of mast cells in different organs. Recent studies have demonstrated that patients suffering from mastocytosis face an increased risk of melanoma and non-melanoma skin cancer. The cause of this has not yet been clearly identified. In the literature, the potential influence of several factors has been suggested, including genetic background, the role of cytokines produced by mast cells, iatrogenic and hormonal factors. The article summarizes the current state of knowledge regarding the epidemiology, pathogenesis, diagnosis, and management of skin neoplasia in mastocytosis patients. MDPI 2023-06-07 /pmc/articles/PMC10298540/ /pubmed/37372988 http://dx.doi.org/10.3390/ijms24129840 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kaszuba, Agnieszka
Sławińska, Martyna
Żółkiewicz, Jakub
Sobjanek, Michał
Nowicki, Roman J.
Lange, Magdalena
Mastocytosis and Skin Cancer: The Current State of Knowledge
title Mastocytosis and Skin Cancer: The Current State of Knowledge
title_full Mastocytosis and Skin Cancer: The Current State of Knowledge
title_fullStr Mastocytosis and Skin Cancer: The Current State of Knowledge
title_full_unstemmed Mastocytosis and Skin Cancer: The Current State of Knowledge
title_short Mastocytosis and Skin Cancer: The Current State of Knowledge
title_sort mastocytosis and skin cancer: the current state of knowledge
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298540/
https://www.ncbi.nlm.nih.gov/pubmed/37372988
http://dx.doi.org/10.3390/ijms24129840
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