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What Do We Know about Nociplastic Pain?

Nociplastic pain is a recently distinguished type of pain, distinct from neuropathic and nociceptive pain, and is well described in the literature. It is often mistaken for central sensitization. Pathophysiology has not been clearly established with regard to alteration of the concentration of spina...

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Autores principales: Bułdyś, Kacper, Górnicki, Tomasz, Kałka, Dariusz, Szuster, Ewa, Biernikiewicz, Małgorzata, Markuszewski, Leszek, Sobieszczańska, Małgorzata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298569/
https://www.ncbi.nlm.nih.gov/pubmed/37372912
http://dx.doi.org/10.3390/healthcare11121794
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author Bułdyś, Kacper
Górnicki, Tomasz
Kałka, Dariusz
Szuster, Ewa
Biernikiewicz, Małgorzata
Markuszewski, Leszek
Sobieszczańska, Małgorzata
author_facet Bułdyś, Kacper
Górnicki, Tomasz
Kałka, Dariusz
Szuster, Ewa
Biernikiewicz, Małgorzata
Markuszewski, Leszek
Sobieszczańska, Małgorzata
author_sort Bułdyś, Kacper
collection PubMed
description Nociplastic pain is a recently distinguished type of pain, distinct from neuropathic and nociceptive pain, and is well described in the literature. It is often mistaken for central sensitization. Pathophysiology has not been clearly established with regard to alteration of the concentration of spinal fluid elements, the structure of the white and gray matter of the brain, and psychological aspects. Many different diagnostic tools, i.e., the painDETECT and Douleur Neuropathique 4 questionnaires, have been developed to diagnose neuropathic pain, but they can also be applied for nociplastic pain; however, more standardized instruments are still needed in order to assess its occurrence and clinical presentation. Numerous studies have shown that nociplastic pain is present in many different diseases such as fibromyalgia, complex regional pain syndrome type 1, and irritable bowel syndrome. Current pharmacological and nonpharmacological treatments for nociceptive and neuropathic pain are not entirely suitable for treating nociplastic pain. There is an ongoing effort to establish the most efficient way to manage it. The significance of this field has led to several clinical trials being carried out in a short time. The aim of this narrative review was to discuss the currently available evidence on pathophysiology, associated diseases, treatment possibilities, and clinical trials. It is important that physicians widely discuss and acknowledge this relatively new concept in order to provide optimized pain control for patients.
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spelling pubmed-102985692023-06-28 What Do We Know about Nociplastic Pain? Bułdyś, Kacper Górnicki, Tomasz Kałka, Dariusz Szuster, Ewa Biernikiewicz, Małgorzata Markuszewski, Leszek Sobieszczańska, Małgorzata Healthcare (Basel) Review Nociplastic pain is a recently distinguished type of pain, distinct from neuropathic and nociceptive pain, and is well described in the literature. It is often mistaken for central sensitization. Pathophysiology has not been clearly established with regard to alteration of the concentration of spinal fluid elements, the structure of the white and gray matter of the brain, and psychological aspects. Many different diagnostic tools, i.e., the painDETECT and Douleur Neuropathique 4 questionnaires, have been developed to diagnose neuropathic pain, but they can also be applied for nociplastic pain; however, more standardized instruments are still needed in order to assess its occurrence and clinical presentation. Numerous studies have shown that nociplastic pain is present in many different diseases such as fibromyalgia, complex regional pain syndrome type 1, and irritable bowel syndrome. Current pharmacological and nonpharmacological treatments for nociceptive and neuropathic pain are not entirely suitable for treating nociplastic pain. There is an ongoing effort to establish the most efficient way to manage it. The significance of this field has led to several clinical trials being carried out in a short time. The aim of this narrative review was to discuss the currently available evidence on pathophysiology, associated diseases, treatment possibilities, and clinical trials. It is important that physicians widely discuss and acknowledge this relatively new concept in order to provide optimized pain control for patients. MDPI 2023-06-17 /pmc/articles/PMC10298569/ /pubmed/37372912 http://dx.doi.org/10.3390/healthcare11121794 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bułdyś, Kacper
Górnicki, Tomasz
Kałka, Dariusz
Szuster, Ewa
Biernikiewicz, Małgorzata
Markuszewski, Leszek
Sobieszczańska, Małgorzata
What Do We Know about Nociplastic Pain?
title What Do We Know about Nociplastic Pain?
title_full What Do We Know about Nociplastic Pain?
title_fullStr What Do We Know about Nociplastic Pain?
title_full_unstemmed What Do We Know about Nociplastic Pain?
title_short What Do We Know about Nociplastic Pain?
title_sort what do we know about nociplastic pain?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298569/
https://www.ncbi.nlm.nih.gov/pubmed/37372912
http://dx.doi.org/10.3390/healthcare11121794
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