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What Do We Know about Nociplastic Pain?
Nociplastic pain is a recently distinguished type of pain, distinct from neuropathic and nociceptive pain, and is well described in the literature. It is often mistaken for central sensitization. Pathophysiology has not been clearly established with regard to alteration of the concentration of spina...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298569/ https://www.ncbi.nlm.nih.gov/pubmed/37372912 http://dx.doi.org/10.3390/healthcare11121794 |
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author | Bułdyś, Kacper Górnicki, Tomasz Kałka, Dariusz Szuster, Ewa Biernikiewicz, Małgorzata Markuszewski, Leszek Sobieszczańska, Małgorzata |
author_facet | Bułdyś, Kacper Górnicki, Tomasz Kałka, Dariusz Szuster, Ewa Biernikiewicz, Małgorzata Markuszewski, Leszek Sobieszczańska, Małgorzata |
author_sort | Bułdyś, Kacper |
collection | PubMed |
description | Nociplastic pain is a recently distinguished type of pain, distinct from neuropathic and nociceptive pain, and is well described in the literature. It is often mistaken for central sensitization. Pathophysiology has not been clearly established with regard to alteration of the concentration of spinal fluid elements, the structure of the white and gray matter of the brain, and psychological aspects. Many different diagnostic tools, i.e., the painDETECT and Douleur Neuropathique 4 questionnaires, have been developed to diagnose neuropathic pain, but they can also be applied for nociplastic pain; however, more standardized instruments are still needed in order to assess its occurrence and clinical presentation. Numerous studies have shown that nociplastic pain is present in many different diseases such as fibromyalgia, complex regional pain syndrome type 1, and irritable bowel syndrome. Current pharmacological and nonpharmacological treatments for nociceptive and neuropathic pain are not entirely suitable for treating nociplastic pain. There is an ongoing effort to establish the most efficient way to manage it. The significance of this field has led to several clinical trials being carried out in a short time. The aim of this narrative review was to discuss the currently available evidence on pathophysiology, associated diseases, treatment possibilities, and clinical trials. It is important that physicians widely discuss and acknowledge this relatively new concept in order to provide optimized pain control for patients. |
format | Online Article Text |
id | pubmed-10298569 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102985692023-06-28 What Do We Know about Nociplastic Pain? Bułdyś, Kacper Górnicki, Tomasz Kałka, Dariusz Szuster, Ewa Biernikiewicz, Małgorzata Markuszewski, Leszek Sobieszczańska, Małgorzata Healthcare (Basel) Review Nociplastic pain is a recently distinguished type of pain, distinct from neuropathic and nociceptive pain, and is well described in the literature. It is often mistaken for central sensitization. Pathophysiology has not been clearly established with regard to alteration of the concentration of spinal fluid elements, the structure of the white and gray matter of the brain, and psychological aspects. Many different diagnostic tools, i.e., the painDETECT and Douleur Neuropathique 4 questionnaires, have been developed to diagnose neuropathic pain, but they can also be applied for nociplastic pain; however, more standardized instruments are still needed in order to assess its occurrence and clinical presentation. Numerous studies have shown that nociplastic pain is present in many different diseases such as fibromyalgia, complex regional pain syndrome type 1, and irritable bowel syndrome. Current pharmacological and nonpharmacological treatments for nociceptive and neuropathic pain are not entirely suitable for treating nociplastic pain. There is an ongoing effort to establish the most efficient way to manage it. The significance of this field has led to several clinical trials being carried out in a short time. The aim of this narrative review was to discuss the currently available evidence on pathophysiology, associated diseases, treatment possibilities, and clinical trials. It is important that physicians widely discuss and acknowledge this relatively new concept in order to provide optimized pain control for patients. MDPI 2023-06-17 /pmc/articles/PMC10298569/ /pubmed/37372912 http://dx.doi.org/10.3390/healthcare11121794 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bułdyś, Kacper Górnicki, Tomasz Kałka, Dariusz Szuster, Ewa Biernikiewicz, Małgorzata Markuszewski, Leszek Sobieszczańska, Małgorzata What Do We Know about Nociplastic Pain? |
title | What Do We Know about Nociplastic Pain? |
title_full | What Do We Know about Nociplastic Pain? |
title_fullStr | What Do We Know about Nociplastic Pain? |
title_full_unstemmed | What Do We Know about Nociplastic Pain? |
title_short | What Do We Know about Nociplastic Pain? |
title_sort | what do we know about nociplastic pain? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298569/ https://www.ncbi.nlm.nih.gov/pubmed/37372912 http://dx.doi.org/10.3390/healthcare11121794 |
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