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Meta-CF(3)-Substituted Analogues of the GFP Chromophore with Remarkable Solvatochromism

In this work, we have shown that the introduction of a trifluoromethyl group into the me-ta-position of arylidene imidazolones (GFP chromophore core) leads to a dramatic increase in their fluorescence in nonpolar and aprotic media. The presence of a pronounced solvent-dependent gradation of fluoresc...

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Detalles Bibliográficos
Autores principales: Perfilov, Maxim M., Zaitseva, Elvira R., Baleeva, Nadezhda S., Kublitski, Vadim S., Smirnov, Alexander Yu., Bogdanova, Yulia A., Krasnova, Svetlana A., Myasnyanko, Ivan N., Mishin, Alexander S., Baranov, Mikhail S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298595/
https://www.ncbi.nlm.nih.gov/pubmed/37373071
http://dx.doi.org/10.3390/ijms24129923
Descripción
Sumario:In this work, we have shown that the introduction of a trifluoromethyl group into the me-ta-position of arylidene imidazolones (GFP chromophore core) leads to a dramatic increase in their fluorescence in nonpolar and aprotic media. The presence of a pronounced solvent-dependent gradation of fluorescence intensity makes it possible to use these substances as fluorescent polarity sensors. In particular, we showed that one of the created compounds could be used for selective labeling of the endoplasmic reticulum of living cells.