Cargando…

Genome-Wide Search for Associations with Meat Production Parameters in Karachaevsky Sheep Breed Using the Illumina BeadChip 600 K

In a group of Karachaevsky rams, a genome-wide associations analysis of single nucleotide polymorphisms (SNPs) with live parameters of meat production was performed. We used for genotyping the Ovine Infinium HD BeadChip 600 K, which consists of points to detection of 606,000 polymorphisms. A total o...

Descripción completa

Detalles Bibliográficos
Autores principales: Krivoruchko, Alexander, Likhovid, Andrey, Kanibolotskaya, Anastasiya, Saprikina, Tatiana, Safaryan, Elena, Yatsyk, Olesya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298605/
https://www.ncbi.nlm.nih.gov/pubmed/37372468
http://dx.doi.org/10.3390/genes14061288
_version_ 1785064157987471360
author Krivoruchko, Alexander
Likhovid, Andrey
Kanibolotskaya, Anastasiya
Saprikina, Tatiana
Safaryan, Elena
Yatsyk, Olesya
author_facet Krivoruchko, Alexander
Likhovid, Andrey
Kanibolotskaya, Anastasiya
Saprikina, Tatiana
Safaryan, Elena
Yatsyk, Olesya
author_sort Krivoruchko, Alexander
collection PubMed
description In a group of Karachaevsky rams, a genome-wide associations analysis of single nucleotide polymorphisms (SNPs) with live parameters of meat production was performed. We used for genotyping the Ovine Infinium HD BeadChip 600 K, which consists of points to detection of 606,000 polymorphisms. A total of 12 SNPs was found to be significantly associated with live meat quality parameters of the corpus and legs and ultrasonic traits. In this case, 11 candidate genes were described, the polymorphic variants of which can change in sheep body parameters. We found SNPs in the exons, introns, and other regions of some genes and transcripts: CLVS1, EVC2, KIF13B, ENSOART00000000511.1, KCNH5, NEDD4, LUZP2, MREG, KRT20, KRT23 and FZD6. The described genes involved in the metabolic pathways of cell differentiation, proliferation and apoptosis are connected with the regulation of the gastrointestinal, immune and nervous systems. In known productivity genes (MSTN, MEF2B, FABP4, etc.), loci were not found to be a significant presence of influence on the meat productivity of the Karachaevsky sheep phenotypes. Our study confirms the possible involvement of the identified candidate genes in the formation of the phenotypes of productivity traits in sheep and indicates the need for new research into candidate genes structure in point to detect their polymorphisms.
format Online
Article
Text
id pubmed-10298605
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102986052023-06-28 Genome-Wide Search for Associations with Meat Production Parameters in Karachaevsky Sheep Breed Using the Illumina BeadChip 600 K Krivoruchko, Alexander Likhovid, Andrey Kanibolotskaya, Anastasiya Saprikina, Tatiana Safaryan, Elena Yatsyk, Olesya Genes (Basel) Article In a group of Karachaevsky rams, a genome-wide associations analysis of single nucleotide polymorphisms (SNPs) with live parameters of meat production was performed. We used for genotyping the Ovine Infinium HD BeadChip 600 K, which consists of points to detection of 606,000 polymorphisms. A total of 12 SNPs was found to be significantly associated with live meat quality parameters of the corpus and legs and ultrasonic traits. In this case, 11 candidate genes were described, the polymorphic variants of which can change in sheep body parameters. We found SNPs in the exons, introns, and other regions of some genes and transcripts: CLVS1, EVC2, KIF13B, ENSOART00000000511.1, KCNH5, NEDD4, LUZP2, MREG, KRT20, KRT23 and FZD6. The described genes involved in the metabolic pathways of cell differentiation, proliferation and apoptosis are connected with the regulation of the gastrointestinal, immune and nervous systems. In known productivity genes (MSTN, MEF2B, FABP4, etc.), loci were not found to be a significant presence of influence on the meat productivity of the Karachaevsky sheep phenotypes. Our study confirms the possible involvement of the identified candidate genes in the formation of the phenotypes of productivity traits in sheep and indicates the need for new research into candidate genes structure in point to detect their polymorphisms. MDPI 2023-06-19 /pmc/articles/PMC10298605/ /pubmed/37372468 http://dx.doi.org/10.3390/genes14061288 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Krivoruchko, Alexander
Likhovid, Andrey
Kanibolotskaya, Anastasiya
Saprikina, Tatiana
Safaryan, Elena
Yatsyk, Olesya
Genome-Wide Search for Associations with Meat Production Parameters in Karachaevsky Sheep Breed Using the Illumina BeadChip 600 K
title Genome-Wide Search for Associations with Meat Production Parameters in Karachaevsky Sheep Breed Using the Illumina BeadChip 600 K
title_full Genome-Wide Search for Associations with Meat Production Parameters in Karachaevsky Sheep Breed Using the Illumina BeadChip 600 K
title_fullStr Genome-Wide Search for Associations with Meat Production Parameters in Karachaevsky Sheep Breed Using the Illumina BeadChip 600 K
title_full_unstemmed Genome-Wide Search for Associations with Meat Production Parameters in Karachaevsky Sheep Breed Using the Illumina BeadChip 600 K
title_short Genome-Wide Search for Associations with Meat Production Parameters in Karachaevsky Sheep Breed Using the Illumina BeadChip 600 K
title_sort genome-wide search for associations with meat production parameters in karachaevsky sheep breed using the illumina beadchip 600 k
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298605/
https://www.ncbi.nlm.nih.gov/pubmed/37372468
http://dx.doi.org/10.3390/genes14061288
work_keys_str_mv AT krivoruchkoalexander genomewidesearchforassociationswithmeatproductionparametersinkarachaevskysheepbreedusingtheilluminabeadchip600k
AT likhovidandrey genomewidesearchforassociationswithmeatproductionparametersinkarachaevskysheepbreedusingtheilluminabeadchip600k
AT kanibolotskayaanastasiya genomewidesearchforassociationswithmeatproductionparametersinkarachaevskysheepbreedusingtheilluminabeadchip600k
AT saprikinatatiana genomewidesearchforassociationswithmeatproductionparametersinkarachaevskysheepbreedusingtheilluminabeadchip600k
AT safaryanelena genomewidesearchforassociationswithmeatproductionparametersinkarachaevskysheepbreedusingtheilluminabeadchip600k
AT yatsykolesya genomewidesearchforassociationswithmeatproductionparametersinkarachaevskysheepbreedusingtheilluminabeadchip600k