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Structural basis for proapoptotic activation of Bak by the noncanonical BH3-only protein Pxt1

Bak is a critical executor of apoptosis belonging to the Bcl-2 protein family. Bak contains a hydrophobic groove where the BH3 domain of proapoptotic Bcl-2 family members can be accommodated, which initiates its activation. Once activated, Bak undergoes a conformational change to oligomerize, which...

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Detalles Bibliográficos
Autores principales:	Lim, Dahwan, Choe, So-Hui, Jin, Sein, Lee, Seulgi, Kim, Younjin, Shin, Ho-Chul, Choi, Joon Sig, Oh, Doo-Byoung, Kim, Seung Jun, Seo, Jinho, Ku, Bonsu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298792/ https://www.ncbi.nlm.nih.gov/pubmed/37315086 http://dx.doi.org/10.1371/journal.pbio.3002156

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