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Protein Biomarkers in Chronic Kidney Disease in Children—What Do We Know So Far?

Chronic kidney disease (CKD) in children is a major concern of medical care and public health as it is related to high morbidity and mortality due to progression to end-stage kidney disease (ESKD). It is essential to identify patients with a risk of developing CKD to implement therapeutic interventi...

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Autores principales: Rybi Szumińska, Agnieszka, Wasilewska, Anna, Kamianowska, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298870/
https://www.ncbi.nlm.nih.gov/pubmed/37373629
http://dx.doi.org/10.3390/jcm12123934
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author Rybi Szumińska, Agnieszka
Wasilewska, Anna
Kamianowska, Monika
author_facet Rybi Szumińska, Agnieszka
Wasilewska, Anna
Kamianowska, Monika
author_sort Rybi Szumińska, Agnieszka
collection PubMed
description Chronic kidney disease (CKD) in children is a major concern of medical care and public health as it is related to high morbidity and mortality due to progression to end-stage kidney disease (ESKD). It is essential to identify patients with a risk of developing CKD to implement therapeutic interventions. Unfortunately, conventional markers of CKD, such as serum creatinine, glomerular filtration rate (GFR) and proteinuria, have many limitations in serving as an early and specific diagnostic tool for this condition. Despite the above, they are still the most frequently utilized as we do not have better. Studies from the last decade identified multiple CKD blood and urine protein biomarkers but mostly assessed the adult population. This article outlines some recent achievements and new perspectives in finding a set of protein biomarkers that might improve our ability to prognose CKD progression in children, monitor the response to treatment, or even become a potential therapeutic target.
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spelling pubmed-102988702023-06-28 Protein Biomarkers in Chronic Kidney Disease in Children—What Do We Know So Far? Rybi Szumińska, Agnieszka Wasilewska, Anna Kamianowska, Monika J Clin Med Review Chronic kidney disease (CKD) in children is a major concern of medical care and public health as it is related to high morbidity and mortality due to progression to end-stage kidney disease (ESKD). It is essential to identify patients with a risk of developing CKD to implement therapeutic interventions. Unfortunately, conventional markers of CKD, such as serum creatinine, glomerular filtration rate (GFR) and proteinuria, have many limitations in serving as an early and specific diagnostic tool for this condition. Despite the above, they are still the most frequently utilized as we do not have better. Studies from the last decade identified multiple CKD blood and urine protein biomarkers but mostly assessed the adult population. This article outlines some recent achievements and new perspectives in finding a set of protein biomarkers that might improve our ability to prognose CKD progression in children, monitor the response to treatment, or even become a potential therapeutic target. MDPI 2023-06-08 /pmc/articles/PMC10298870/ /pubmed/37373629 http://dx.doi.org/10.3390/jcm12123934 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rybi Szumińska, Agnieszka
Wasilewska, Anna
Kamianowska, Monika
Protein Biomarkers in Chronic Kidney Disease in Children—What Do We Know So Far?
title Protein Biomarkers in Chronic Kidney Disease in Children—What Do We Know So Far?
title_full Protein Biomarkers in Chronic Kidney Disease in Children—What Do We Know So Far?
title_fullStr Protein Biomarkers in Chronic Kidney Disease in Children—What Do We Know So Far?
title_full_unstemmed Protein Biomarkers in Chronic Kidney Disease in Children—What Do We Know So Far?
title_short Protein Biomarkers in Chronic Kidney Disease in Children—What Do We Know So Far?
title_sort protein biomarkers in chronic kidney disease in children—what do we know so far?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298870/
https://www.ncbi.nlm.nih.gov/pubmed/37373629
http://dx.doi.org/10.3390/jcm12123934
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