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Adult-Onset Neuroepidemiology in Finland: Lessons to Learn and Work to Do
Finland is a relatively small genetic isolate with a genetically non-homogenous population. Available Finnish data on neuroepidemiology of adult-onset disorders are limited, and this paper describes the conclusions that can be drawn and their implications. Apparently, Finnish people have a (relative...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298930/ https://www.ncbi.nlm.nih.gov/pubmed/37373667 http://dx.doi.org/10.3390/jcm12123972 |
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author | Sipilä, Jussi O. T. |
author_facet | Sipilä, Jussi O. T. |
author_sort | Sipilä, Jussi O. T. |
collection | PubMed |
description | Finland is a relatively small genetic isolate with a genetically non-homogenous population. Available Finnish data on neuroepidemiology of adult-onset disorders are limited, and this paper describes the conclusions that can be drawn and their implications. Apparently, Finnish people have a (relatively) high risk of developing Unverricht-Lundborg disease (EPM1), Multiple Sclerosis (MS), Amyotrophic Lateral Sclerosis (ALS), Spinal muscular atrophy, Jokela type (SMAJ) and adult-onset dystonia. On the other hand, some disorders, such as Friedreich’s ataxia (FRDA) and Wilson’s disease (WD), are almost absent or completely absent in the population. Valid and timely data concerning even many common disorders, such as stroke, migraine, neuropathy, Alzheimer’s disease and Parkinson’s disease, are unavailable, and there are virtually no data on many less-common neurological disorders, such as neurosarcoidosis or autoimmune encephalitides. There also appear to be marked regional differences in the incidence and prevalence of many diseases, suggesting that non-granular nationwide data may be misleading in many cases. Concentrated efforts to advance neuroepidemiological research in the country would be of clinical, administrative and scientific benefit, but currently, all progress is blocked by administrative and financial obstacles. |
format | Online Article Text |
id | pubmed-10298930 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102989302023-06-28 Adult-Onset Neuroepidemiology in Finland: Lessons to Learn and Work to Do Sipilä, Jussi O. T. J Clin Med Review Finland is a relatively small genetic isolate with a genetically non-homogenous population. Available Finnish data on neuroepidemiology of adult-onset disorders are limited, and this paper describes the conclusions that can be drawn and their implications. Apparently, Finnish people have a (relatively) high risk of developing Unverricht-Lundborg disease (EPM1), Multiple Sclerosis (MS), Amyotrophic Lateral Sclerosis (ALS), Spinal muscular atrophy, Jokela type (SMAJ) and adult-onset dystonia. On the other hand, some disorders, such as Friedreich’s ataxia (FRDA) and Wilson’s disease (WD), are almost absent or completely absent in the population. Valid and timely data concerning even many common disorders, such as stroke, migraine, neuropathy, Alzheimer’s disease and Parkinson’s disease, are unavailable, and there are virtually no data on many less-common neurological disorders, such as neurosarcoidosis or autoimmune encephalitides. There also appear to be marked regional differences in the incidence and prevalence of many diseases, suggesting that non-granular nationwide data may be misleading in many cases. Concentrated efforts to advance neuroepidemiological research in the country would be of clinical, administrative and scientific benefit, but currently, all progress is blocked by administrative and financial obstacles. MDPI 2023-06-11 /pmc/articles/PMC10298930/ /pubmed/37373667 http://dx.doi.org/10.3390/jcm12123972 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sipilä, Jussi O. T. Adult-Onset Neuroepidemiology in Finland: Lessons to Learn and Work to Do |
title | Adult-Onset Neuroepidemiology in Finland: Lessons to Learn and Work to Do |
title_full | Adult-Onset Neuroepidemiology in Finland: Lessons to Learn and Work to Do |
title_fullStr | Adult-Onset Neuroepidemiology in Finland: Lessons to Learn and Work to Do |
title_full_unstemmed | Adult-Onset Neuroepidemiology in Finland: Lessons to Learn and Work to Do |
title_short | Adult-Onset Neuroepidemiology in Finland: Lessons to Learn and Work to Do |
title_sort | adult-onset neuroepidemiology in finland: lessons to learn and work to do |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298930/ https://www.ncbi.nlm.nih.gov/pubmed/37373667 http://dx.doi.org/10.3390/jcm12123972 |
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