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Platelet-Derived Microparticles and Autoimmune Diseases
Extracellular microparticles provide a means of cell-to-cell communication and can promote information exchanges between adjacent or distant cells. Platelets are cell fragments that are derived from megakaryocytes. Their main functions are to stop bleeding, regulate inflammation, and maintain the in...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298940/ https://www.ncbi.nlm.nih.gov/pubmed/37373420 http://dx.doi.org/10.3390/ijms241210275 |
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author | Li, Xiaoshuai Wang, Qiushi |
author_facet | Li, Xiaoshuai Wang, Qiushi |
author_sort | Li, Xiaoshuai |
collection | PubMed |
description | Extracellular microparticles provide a means of cell-to-cell communication and can promote information exchanges between adjacent or distant cells. Platelets are cell fragments that are derived from megakaryocytes. Their main functions are to stop bleeding, regulate inflammation, and maintain the integrity of blood vessels. When platelets are activated, they can perform related tasks by secreting platelet-derived microparticles that contain lipids, proteins, nucleic acids, and even organelles. There are differences in the circulating platelet levels in many autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, antiphospholipid antibody syndrome, and Sjogren’s syndrome. In this paper, the latest findings in the research field of platelet-derived microparticles are reviewed, including the potential pathogenesis of platelet-derived microparticles in various types of immune diseases, their potential as related markers, and for monitoring the progress and prognosis of disease treatment are expounded. |
format | Online Article Text |
id | pubmed-10298940 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102989402023-06-28 Platelet-Derived Microparticles and Autoimmune Diseases Li, Xiaoshuai Wang, Qiushi Int J Mol Sci Review Extracellular microparticles provide a means of cell-to-cell communication and can promote information exchanges between adjacent or distant cells. Platelets are cell fragments that are derived from megakaryocytes. Their main functions are to stop bleeding, regulate inflammation, and maintain the integrity of blood vessels. When platelets are activated, they can perform related tasks by secreting platelet-derived microparticles that contain lipids, proteins, nucleic acids, and even organelles. There are differences in the circulating platelet levels in many autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, antiphospholipid antibody syndrome, and Sjogren’s syndrome. In this paper, the latest findings in the research field of platelet-derived microparticles are reviewed, including the potential pathogenesis of platelet-derived microparticles in various types of immune diseases, their potential as related markers, and for monitoring the progress and prognosis of disease treatment are expounded. MDPI 2023-06-17 /pmc/articles/PMC10298940/ /pubmed/37373420 http://dx.doi.org/10.3390/ijms241210275 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Li, Xiaoshuai Wang, Qiushi Platelet-Derived Microparticles and Autoimmune Diseases |
title | Platelet-Derived Microparticles and Autoimmune Diseases |
title_full | Platelet-Derived Microparticles and Autoimmune Diseases |
title_fullStr | Platelet-Derived Microparticles and Autoimmune Diseases |
title_full_unstemmed | Platelet-Derived Microparticles and Autoimmune Diseases |
title_short | Platelet-Derived Microparticles and Autoimmune Diseases |
title_sort | platelet-derived microparticles and autoimmune diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298940/ https://www.ncbi.nlm.nih.gov/pubmed/37373420 http://dx.doi.org/10.3390/ijms241210275 |
work_keys_str_mv | AT lixiaoshuai plateletderivedmicroparticlesandautoimmunediseases AT wangqiushi plateletderivedmicroparticlesandautoimmunediseases |