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Platelet-Derived Microparticles and Autoimmune Diseases

Extracellular microparticles provide a means of cell-to-cell communication and can promote information exchanges between adjacent or distant cells. Platelets are cell fragments that are derived from megakaryocytes. Their main functions are to stop bleeding, regulate inflammation, and maintain the in...

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Detalles Bibliográficos
Autores principales: Li, Xiaoshuai, Wang, Qiushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298940/
https://www.ncbi.nlm.nih.gov/pubmed/37373420
http://dx.doi.org/10.3390/ijms241210275
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author Li, Xiaoshuai
Wang, Qiushi
author_facet Li, Xiaoshuai
Wang, Qiushi
author_sort Li, Xiaoshuai
collection PubMed
description Extracellular microparticles provide a means of cell-to-cell communication and can promote information exchanges between adjacent or distant cells. Platelets are cell fragments that are derived from megakaryocytes. Their main functions are to stop bleeding, regulate inflammation, and maintain the integrity of blood vessels. When platelets are activated, they can perform related tasks by secreting platelet-derived microparticles that contain lipids, proteins, nucleic acids, and even organelles. There are differences in the circulating platelet levels in many autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, antiphospholipid antibody syndrome, and Sjogren’s syndrome. In this paper, the latest findings in the research field of platelet-derived microparticles are reviewed, including the potential pathogenesis of platelet-derived microparticles in various types of immune diseases, their potential as related markers, and for monitoring the progress and prognosis of disease treatment are expounded.
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spelling pubmed-102989402023-06-28 Platelet-Derived Microparticles and Autoimmune Diseases Li, Xiaoshuai Wang, Qiushi Int J Mol Sci Review Extracellular microparticles provide a means of cell-to-cell communication and can promote information exchanges between adjacent or distant cells. Platelets are cell fragments that are derived from megakaryocytes. Their main functions are to stop bleeding, regulate inflammation, and maintain the integrity of blood vessels. When platelets are activated, they can perform related tasks by secreting platelet-derived microparticles that contain lipids, proteins, nucleic acids, and even organelles. There are differences in the circulating platelet levels in many autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, antiphospholipid antibody syndrome, and Sjogren’s syndrome. In this paper, the latest findings in the research field of platelet-derived microparticles are reviewed, including the potential pathogenesis of platelet-derived microparticles in various types of immune diseases, their potential as related markers, and for monitoring the progress and prognosis of disease treatment are expounded. MDPI 2023-06-17 /pmc/articles/PMC10298940/ /pubmed/37373420 http://dx.doi.org/10.3390/ijms241210275 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Li, Xiaoshuai
Wang, Qiushi
Platelet-Derived Microparticles and Autoimmune Diseases
title Platelet-Derived Microparticles and Autoimmune Diseases
title_full Platelet-Derived Microparticles and Autoimmune Diseases
title_fullStr Platelet-Derived Microparticles and Autoimmune Diseases
title_full_unstemmed Platelet-Derived Microparticles and Autoimmune Diseases
title_short Platelet-Derived Microparticles and Autoimmune Diseases
title_sort platelet-derived microparticles and autoimmune diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298940/
https://www.ncbi.nlm.nih.gov/pubmed/37373420
http://dx.doi.org/10.3390/ijms241210275
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