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Bone Morphogenic Protein and Mesenchymal Stem Cells to Regenerate Bone in Calvarial Defects: A Systematic Review

Background: The use of bone morphogenic protein and mesenchymal stem cells has shown promise in promoting bone regeneration in calvarial defects. However, a systematic review of the available literature is needed to evaluate the efficacy of this approach. Methods: We comprehensively searched electro...

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Autores principales: Torres-Guzman, Ricardo A., Avila, Francisco R., Maita, Karla C., Garcia, John P., De Sario, Gioacchino D., Borna, Sahar, Eldaly, Abdullah S., Quinones-Hinojosa, Alfredo, Zubair, Abba C., Ho, Olivia A., Forte, Antonio J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298978/
https://www.ncbi.nlm.nih.gov/pubmed/37373757
http://dx.doi.org/10.3390/jcm12124064
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author Torres-Guzman, Ricardo A.
Avila, Francisco R.
Maita, Karla C.
Garcia, John P.
De Sario, Gioacchino D.
Borna, Sahar
Eldaly, Abdullah S.
Quinones-Hinojosa, Alfredo
Zubair, Abba C.
Ho, Olivia A.
Forte, Antonio J.
author_facet Torres-Guzman, Ricardo A.
Avila, Francisco R.
Maita, Karla C.
Garcia, John P.
De Sario, Gioacchino D.
Borna, Sahar
Eldaly, Abdullah S.
Quinones-Hinojosa, Alfredo
Zubair, Abba C.
Ho, Olivia A.
Forte, Antonio J.
author_sort Torres-Guzman, Ricardo A.
collection PubMed
description Background: The use of bone morphogenic protein and mesenchymal stem cells has shown promise in promoting bone regeneration in calvarial defects. However, a systematic review of the available literature is needed to evaluate the efficacy of this approach. Methods: We comprehensively searched electronic databases using MeSH terms related to skull defects, bone marrow mesenchymal stem cells, and bone morphogenic proteins. Eligible studies included animal studies that used BMP therapy and mesenchymal stem cells to promote bone regeneration in calvarial defects. Reviews, conference articles, book chapters, and non-English language studies were excluded. Two independent investigators conducted the search and data extraction. Results: Twenty-three studies published between 2010 and 2022 met our inclusion criteria after a full-text review of the forty-five records found in the search. Eight of the 23 studies used mice as models, while 15 used rats. The most common mesenchymal stem cell was bone marrow-derived, followed by adipose-derived. BMP-2 was the most popular. Stem cells were embedded in Scaffold (13), Transduction (7), and Transfection (3), and they were delivered BMP to cells. Each treatment used 2 × 10(4)–1 × 10(7) mesenchymal stem cells, averaging 2.26 × 10(6). Most BMP-transduced MSC studies used lentivirus. Conclusions: This systematic review examined BMP and MSC synergy in biomaterial scaffolds or alone. BMP therapy and mesenchymal stem cells in calvarial defects, alone, or with a scaffold regenerated bone. This method treats skull defects in clinical trials. The best scaffold material, therapeutic dosage, administration method, and long-term side effects need further study.
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spelling pubmed-102989782023-06-28 Bone Morphogenic Protein and Mesenchymal Stem Cells to Regenerate Bone in Calvarial Defects: A Systematic Review Torres-Guzman, Ricardo A. Avila, Francisco R. Maita, Karla C. Garcia, John P. De Sario, Gioacchino D. Borna, Sahar Eldaly, Abdullah S. Quinones-Hinojosa, Alfredo Zubair, Abba C. Ho, Olivia A. Forte, Antonio J. J Clin Med Systematic Review Background: The use of bone morphogenic protein and mesenchymal stem cells has shown promise in promoting bone regeneration in calvarial defects. However, a systematic review of the available literature is needed to evaluate the efficacy of this approach. Methods: We comprehensively searched electronic databases using MeSH terms related to skull defects, bone marrow mesenchymal stem cells, and bone morphogenic proteins. Eligible studies included animal studies that used BMP therapy and mesenchymal stem cells to promote bone regeneration in calvarial defects. Reviews, conference articles, book chapters, and non-English language studies were excluded. Two independent investigators conducted the search and data extraction. Results: Twenty-three studies published between 2010 and 2022 met our inclusion criteria after a full-text review of the forty-five records found in the search. Eight of the 23 studies used mice as models, while 15 used rats. The most common mesenchymal stem cell was bone marrow-derived, followed by adipose-derived. BMP-2 was the most popular. Stem cells were embedded in Scaffold (13), Transduction (7), and Transfection (3), and they were delivered BMP to cells. Each treatment used 2 × 10(4)–1 × 10(7) mesenchymal stem cells, averaging 2.26 × 10(6). Most BMP-transduced MSC studies used lentivirus. Conclusions: This systematic review examined BMP and MSC synergy in biomaterial scaffolds or alone. BMP therapy and mesenchymal stem cells in calvarial defects, alone, or with a scaffold regenerated bone. This method treats skull defects in clinical trials. The best scaffold material, therapeutic dosage, administration method, and long-term side effects need further study. MDPI 2023-06-15 /pmc/articles/PMC10298978/ /pubmed/37373757 http://dx.doi.org/10.3390/jcm12124064 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Torres-Guzman, Ricardo A.
Avila, Francisco R.
Maita, Karla C.
Garcia, John P.
De Sario, Gioacchino D.
Borna, Sahar
Eldaly, Abdullah S.
Quinones-Hinojosa, Alfredo
Zubair, Abba C.
Ho, Olivia A.
Forte, Antonio J.
Bone Morphogenic Protein and Mesenchymal Stem Cells to Regenerate Bone in Calvarial Defects: A Systematic Review
title Bone Morphogenic Protein and Mesenchymal Stem Cells to Regenerate Bone in Calvarial Defects: A Systematic Review
title_full Bone Morphogenic Protein and Mesenchymal Stem Cells to Regenerate Bone in Calvarial Defects: A Systematic Review
title_fullStr Bone Morphogenic Protein and Mesenchymal Stem Cells to Regenerate Bone in Calvarial Defects: A Systematic Review
title_full_unstemmed Bone Morphogenic Protein and Mesenchymal Stem Cells to Regenerate Bone in Calvarial Defects: A Systematic Review
title_short Bone Morphogenic Protein and Mesenchymal Stem Cells to Regenerate Bone in Calvarial Defects: A Systematic Review
title_sort bone morphogenic protein and mesenchymal stem cells to regenerate bone in calvarial defects: a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298978/
https://www.ncbi.nlm.nih.gov/pubmed/37373757
http://dx.doi.org/10.3390/jcm12124064
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